Results 61 to 70 of about 55,716 (280)

On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase

Journal of the American Chemical Society, 2011
Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated.
Spencer C. Peck, Robert M. Cicchillo, Friedrich Hammerschmidt, Petra Malova, Wilfred A. van der Donk, John T. Whitteck   +5 more
openaire   +3 more sources

Genome Sequence and Metabolic Analysis of a Fluoranthene-Degrading Strain Pseudomonas aeruginosa DN1

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa DN1, isolated from petroleum-contaminated soil, showed excellent degradation ability toward diverse polycyclic aromatic hydrocarbons (PAHs). Many studies have been done to improve its degradation ability.
Chunqiu He, Yanpeng Li, Chao Huang, Fulin Chen, Yanling Ma   +4 more
doaj   +1 more source

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Nature Communications, 2016
Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions.
M. White, Maria Klecker, Richard J. Hopkinson, D. A. Weits, C. Mueller, Christin Naumann, Rebecca O’Neill, J. Wickens, Jiayu Yang, Jonathan C. Brooks‐Bartlett, E. Garman, T. Grossmann, Nico Dissmeyer, E. Flashman   +13 more
semanticscholar   +1 more source

Structural, Spectroscopic, and Electrochemical Properties of Nonheme Fe(II)-Hydroquinonate Complexes: Synthetic Models of Hydroquinone Dioxygenases [PDF]

, 2012
Using the tris(3,5-diphenylpyrazol-1-yl)borate (Ph2Tp) supporting ligand, a series of mono- and dinuclear ferrous complexes containing hydroquinonate (HQate) ligands have been prepared and structurally characterized with X-ray crystallography.
Baum, Amanda E., Fiedler, Adam T., Lindeman, Sergey, Park, Heaweon, Wang, Denan   +4 more
core   +2 more sources

Gestational arsenic exposure induces anxiety-like behaviors in adult offspring by reducing DNA hydroxymethylation in the developing brain

Ecotoxicology and Environmental Safety, 2021
Several studies found that reduction of 5-hydroxymethylcytosine (5hmC), a marker of DNA hydroxymethylation highly enriched in developing brain, is associated with anxiety-like behaviors.
Jin-Wei Lv, Ya-Ping Song, Zhi-Cheng Zhang, Yi-Jun Fan, Fei-Xiang Xu, Lan Gao, Xiao-Yi Zhang, Cheng Zhang, Hua Wang, De-Xiang Xu   +9 more
doaj   +1 more source

Structures, Spectroscopic Properties, and Dioxygen Reactivity of 5- and 6-Coordinate Nonheme Iron(II) Complexes: A Combined Enzyme/Model Study of Thiol Dioxygenases.

Journal of the American Chemical Society, 2018
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are described. They are composed of derivatives of the neutral, tridentate ligand triazacyclononane (R3TACN; R = Me, iPr) and 2-aminobenzenethiolate (abtx; X = H,
Jesse B. Gordon, Jeremy P McGale, Joshua R. Prendergast, Zahra Shirani-Sarmazeh, M. Siegler, Guy N. L. Jameson, D. P. Goldberg   +6 more
semanticscholar   +1 more source

Mechanistic Insight on the Activity and Substrate Selectivity of Nonheme Iron Dioxygenases.

The chemical record, 2018
Nonheme iron dioxygenases catalyze vital reactions for human health particularly related to aging processes. They are involved in the biosynthesis of amino acids, but also the biodegradation of toxic compounds. Typically they react with their substrate(s)
S. D. de Visser
semanticscholar   +1 more source

Oxygen Activation by Mononuclear Mn, Co, and Ni Centers in Biology and Synthetic Complexes [PDF]

, 2017
The active sites of metalloenzymes that catalyze O2-dependent reactions generally contain iron or copper ions. However, several enzymes are capable of activating O2 at manganese or nickel centers instead, and a handful of dioxygenases exhibit activity ...
Fiedler, Adam T., Fischer, Anne A.
core   +1 more source

Engineering Non-Heme Mono- and Dioxygenases for Biocatalysis

Computational and Structural Biotechnology Journal, 2012
Oxygenases are ubiquitous enzymes that catalyze the introduction of one or two oxygen atoms to unreactive chemical compounds. They require reduction equivalents from NADH or NADPH and comprise metal ions, metal ion complexes, or coenzymes in their active
Adi Dror, Ayelet Fishman
doaj   +3 more sources

Divergent Pseudomonas aeruginosa LpxO enzymes perform site-specific lipid A 2-hydroxylation

mBio
Pseudomonas aeruginosa can survive in a myriad of environments, partially due to modifications of its lipid A, the membrane anchor of lipopolysaccharide.
Casey E. Hofstaedter, Courtney E. Chandler, Charles M. Met, Joseph J. Gillespie, Janette M. Harro, David R. Goodlett, David A. Rasko, Robert K. Ernst   +7 more
doaj   +1 more source