Results 101 to 110 of about 59,947 (268)

SYNTHESIS OF ALPHA-HYDROXY KETOMETHYLENE DIPEPTIDE ISOSTERES

, 1993
Novel alpha-hydroxy ketomethylene dipeptide isosteres were prepared efficiently front the corresponding 2-isoxazoline dipeptide isosteres ...
RYU, EJ, CHUNG, YJ, KIM, BH
core  

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances

Marine Drugs
Five new metabolites, including three cyclic dipeptide derivatives (1–3) and two new polyketides (10–11), together with nine known ones (4–9 and 12–15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431.
Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xuefeng Zhou   +7 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Self-assembled robust dipeptide nanotubes and fabrication of dipeptide-capped gold nanoparticles on the surface of these nanotubes

, 2009
Three water-soluble dipeptides containing N-terminally located β-alanine residue and C-terminally located α-amino acid residues (β-Ala-L-Xaa, Xaa = Val/Ile/Phe) form robust crystalline nanotubes. These dipeptide nanotubes contain a common motif, a hybrid
Guha, Samit, Banerjee, Arindam
core   +1 more source

The molecular basis of GshT substrate binding reveals how Streptococcus pneumoniae acquires the antioxidant glutathione

The FEBS Journal, EarlyView.
Streptococcus pneumoniae imports glutathione (GSH) from its obligate human host to defend against oxidative stress. GSH import is facilitated through the substrate binding protein (SBP) GshT, relying on charge complementarity between the protein and ligand.
Sarah E. du Toit, Paul E. Pace, Pierre De Cordovez, Christoph Göbl, Nina Dickerhof   +4 more
wiley   +1 more source

Identifying the Mesophilic and Thermophilic Proteins from Their Amino Acid Composition with ν-Support Vector Machines

Journal of Algorithms & Computational Technology, 2010
Many researchers had proved that both single amino acid composition and dipeptide composition can influence protein thermostability. We use ν-support vector machines approach to predict hyperthermophilic protein, thermophilic protein and mesophilic ...
Y. R. Ding, Y. J. Cai, J. Sun, B. W. Xu
doaj   +1 more source

Allyltrichlorostannane additions to chiral dipeptide aldehydes

, 2015
The first examples of successful allylsilane additions to chiral dipeptide aldehydes are described. Treatment of allylsilanes with tin tetrachloride at room temperature affords allyltrichlorostarnnane intermediates that reacts with dipeptide aldehydes to
Ferreira, E, Dias, LC
core   +1 more source