Results 81 to 90 of about 59,947 (268)

Bioactive potential and storage behavior of low molecular mass peptides in Pilsner and IPA style craft beers

Frontiers in Food Science and Technology
Beer, one of the most widely consumed alcoholic beverages globally, is typically produced from barley and hops, and contains carbohydrates, proteins, vitamins, minerals, ethanol, and bioactive phytochemicals such as phenolic compounds.
Roberta Nogueira Pereira da Silva, Angelica Priscila Parussolo Tonin, Gabriela Soares Macello Ramos, Juliana Furtado Dias, Eduardo Cesar Meurer, Maria Gabriela Bello Koblitz   +5 more
doaj   +1 more source

A Green Protocol for the Deprotection of ortho‐Nitrobenzyl Esters and Ethers by UVA–LED Irradiation

Chemistry – A European Journal, EarlyView.
This study presents a green and efficient photochemical protocol for the deprotection of ortho‐nitrobenzyl esters or ethers under mild conditions, using UVA‐LED irradiation in methanol. The broad applicability of the protocol was validated in the synthesis of a cytosolic phospholipase A2 inhibitor. ABSTRACT The removal of protecting groups in synthetic
Despoina Poikilidou, Christiana Mantzourani, George Kokotos, Christoforos G. Kokotos   +3 more
wiley   +1 more source

Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy

, 2018
Oligopeptide transporter 1 (PepT1) has been a striking prodrug-designing target. However, the underlying mechanism of PepT1 as a target to facilitate the oral absorption of nanoparticles (NPs) remains unclear.
Bingjun Sun, Di Huang (360305), Lin Li (28817), Lin Li, Qiming Kan (4975997), Zhonggui He, Menglin Wang, Yuqian Du (1620826), Menglin Wang (1486000), Kexin Liu (1547230), Di Huang, Yan Liu (25061), Wei Wei (21173), Bingjun Sun (2920098), Kexin Liu, Cong Luo (789538), Chutong Tian, Qiming Kan, Jin Sun, Yan Liu, Jin Sun (117866), Chutong Tian (5977481), Wei Wei, Longfa Kou, Cong Luo, Yuqian Du, Longfa Kou (1620844), Zhonggui He (1329060)   +27 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway

Frontiers in Endocrinology, 2018
It has been shown that IGF-1 secretion is influenced by dietary protein or amino acid. However, whether the dipeptides elicit regulatory effects on IGF-1 secretion remains largely unclear.
Mengyuan Zhang, Mengyuan Zhang, Jingren Xu, Jingren Xu, Tao Wang, Tao Wang, Xiaojuan Wan, Xiaojuan Wan, Fenglin Zhang, Fenglin Zhang, Lina Wang, Lina Wang, Xiaotong Zhu, Xiaotong Zhu, Ping Gao, Ping Gao, Gang Shu, Gang Shu, Qingyan Jiang, Qingyan Jiang, Songbo Wang, Songbo Wang   +21 more
doaj   +1 more source

Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

European Journal of Organic Chemistry, EarlyView.
Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori, Luigi Dolcini, Alexander Bell, Joshua P. Barham   +3 more
wiley   +1 more source

Inhibitory Effect of Dipeptides Containing Acidic Amino Acid Residue on Degranulation of RBL-2H3 Cells

Applied Sciences
Upon degranulation, basophils and mast cells secrete an array of inflammatory mediators, including histamine, which leads to not only allergic inflammation but also other inflammatory diseases.
Kosuke Nishi, Taiki Hirakawa, Mitsumasa Izumi, Naoki Kageyama, Senri Yurue, Akari Ozaki, Yuki Toga, Momoko Ishida, Takuya Sugahara   +8 more
doaj   +1 more source

The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine—Feasibility of Orally Administrable Nucleoside Analogs

Pharmaceuticals, 2014
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stability in buffers, enzymatic stability in cell homogenates, permeability in mouse intestinal membrane along with drug concentration in mouse plasma, and anti-
Yasuhiro Tsume, Blanca Borras Bermejo, Gordon L. Amidon   +2 more
doaj   +1 more source

AutoRNC dipeptide conformational libraries

, 2023
These are the dipeptide conformational libraries that are sampled by AutoRNC during construction of nascent protein chain models. This work was supported by the National Institutes of Health, USA (R35 GM122466 to AHE)
Elcock, Adrian H.
core   +1 more source