Results 151 to 160 of about 59,947 (268)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Supramolecular Behaviour of Heterochiral Dipeptides With Ile. [PDF]

J Pept Sci
Scarel E, Alletto P, Adorinni S, Fazio F, Pierri G, Tedesco C, Marchesan S.   +6 more
europepmc   +1 more source

Regulation by the Transcriptional Regulator YdcI in E. coli and (p)ppGpp‐Dependent Activation of ydcI Expression

Molecular Microbiology, Volume 126, Issue 5, Page 503-518, November 2026.
YdcI, a LysR‐type transcription regulator in Escherichia coli, regulates loci like iraP and mqo. Its expression is induced by (p)ppGpp under stress conditions, and protein levels rise during mid‐exponential growth, connecting its role to stress response and metabolism control. ABSTRACT YdcI, a LysR‐type transcription regulator, has been associated with
Ria Basu Roy, Karin Schnetz
wiley   +1 more source

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

New Phytologist, Volume 252, Issue 3, Page 1215-1231, November 2026.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son   +15 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

Prepartum Heat Stress Dysregulates Immune Resilience in Postpartum Dairy Cows

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Increasing environmental temperatures pose a major challenge to animal welfare by inducing heat stress and increasing the incidence of disease. Immune resilience is essential for maintaining animal health; however, the mechanisms linking heat stress to immune dysfunction and disease remain unclear.
Arslan Tariq, Masroor Sagheer, Nicholas C. Kertz, Zachary K. Seekford, Maria A. T. de Bari, Gabriela A. Macay, Sriniwas Pandey, Yuting Zhai, Kwangcheol C. Jeong, Geoffrey E. Dahl, John J. Bromfield   +10 more
wiley   +1 more source

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll, Pia Lanvers, Giulia Ravagnan, Kilian Klaus, Olena Nosovska, Ivan Vilotijevic, Jochen Schmid, Hajo Kries   +7 more
wiley   +2 more sources

Developing CHARMM Force Field Parameters for the Radical States of Tryptophan and Tyrosine. [PDF]

J Chem Theory Comput
Kostritski AY, Hungerland J, Schuster C, Solov'yov IA.   +3 more
europepmc   +1 more source

The <i>Sinorhizobium meliloti</i> chemoreceptor McpU mediates positive and negative chemotaxis responses to dipeptides and competes with periplasmic solute-binding proteins for ligand binding. [PDF]

mBio
Agyei FK, Dhiman N, Scharf BE.
europepmc   +1 more source

A continuous-space analytical framework for committor functions from molecular dynamics. [PDF]

J Chem Phys
Cao S, Huang X.
europepmc   +1 more source