Results 111 to 120 of about 8,444 (178)

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

, 2023
Hexanucleotide repeat expansions in C9ORF72 are the most common genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
A Higginbottom (15321955), C Dominguez (7716539), M Azzouz (15321979), YH Lin (15321943), A Sanchez-Martinez (15321946), LM Castelli (15321940), CS Bauer (15321970), RJ Mead (15321976), A Walton (9684224), L Ferraiuolo (15321982), AJ Whitworth (7674104), K Mohd Imran (15321952), J Cooper-Knock (7744826), A Gül (15321949), R Rua Martins (15321964), SK Upadhyay (15321958), C Montmasson (15321967), PJ Shaw (7653332), NM Márkus (15321961), KJ De Vos (15321973), GM Hautbergue (15321985), R Cohen (11240973)   +21 more
core  

Automated Fast-Flow Synthesis of Chromosome 9 Open Reading Frame 72 Dipeptide Repeat Proteins

An expansion of the hexanucleotide (GGGGCC) repeat sequence in chromosome 9 open frame 72 (c9orf72) is the most common genetic mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jacob Rodriguez (3114627), Bradley L. Pentelute (1247046), Kohei Sato (1494307), Charlotte E. Farquhar (4376245)   +3 more
core   +1 more source

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Nature Communications
The most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is an intronic G4C2 repeat expansion in C9orf72.
Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack, Mireia Carcolé, Martha J. Roberts, Alla Mikheenko, Alessia Fisher, Pacharaporn Suklai, Bhavana Muralidharan, François Kroll, Thomas G. Moens, Lidia Yshii, Stijn Verschoren, Benedikt V. Hölbling, Francisco C. Moreira, Eszter Katona, Rachel Coneys, Paula de Oliveira, Yong-Jie Zhang, Karen Jansen, Lillian M. Daughrity, Alexander McGown, Tennore M. Ramesh, Ludo Van Den Bosch, Gabriele Lignani, Ahad A. Rahim, Alyssa N. Coyne, Leonard Petrucelli, Jason Rihel, Adrian M. Isaacs   +29 more
doaj   +1 more source

Mammalian telomeric RNA (TERRA) can be translated to produce valine-arginine and glycine-leucine dipeptide repeat proteins. [PDF]

Proc Natl Acad Sci U S A, 2023
Al-Turki TM, Griffith JD.
europepmc   +1 more source

Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges. [PDF]

iScience, 2023
Miyagi T, Ueda K, Sugimoto M, Yagi T, Ito D, Yamazaki R, Narumi S, Hayamizu Y, Uji-I H, Kuroda M, Kanekura K.   +10 more
europepmc   +1 more source

Toxic Interplay Between Small Dipeptide Protein Repeats and Tau in Tauopathies

Alzheimer's & Dementia
AbstractBackgroundTauopathies, including Alzheimer’s Disease and Frontotemporal Dementia, are characterized as intracellular lesions composed of aggregated tau proteins. Soluble tau oligomers are shown to be one of the most toxic species and are responsible for the spread of tau pathology. Recent studies have found that several proteins such as amyloid
Bhatt, Nemil, Puangmalai, Nicha, Jerez, Cynthia, Shchankin, Nikita, Kayed, Rakez   +4 more
openaire   +1 more source

C9orf72-derived dipeptide repeat proteins poly-PR disrupt membrane excitability and synaptic function in cortical neurons

Neurobiology of Disease
Amyotrophic lateral sclerosis (ALS) is one of the most fatal neurodegenerative disease, with the most common genetic form of the ALS is associated with hexanucleotide GGGGCC repeat expansions in the first intron of C9orf72 gene.
Shao-Ming Wang, Jui-Cheng Chan, Engkarat Supapatarnun, Chao-Yi Tsai, Phan Thi Ngoc Lan, Eddie Feng-Ju Weng   +5 more
doaj   +1 more source

Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Journal of Central Nervous System Disease, 2014
Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and ...
Jun-Ichi Satoh, Yoji Yamamoto, Shouta Kitano, Mika Takitani, Naohiro Asahina, Yoshihiro Kino   +5 more
doaj   +1 more source

Biochemical Caracterisations of Dipeptides Repeat Proteins and their Assemblies

, 2019
Résumé : La répétition de l’hexanucléotide GGGGCC est le facteur génétique le plus présent chez les patients atteints de démence fronto-temporale (DFT) et de sclérose latérale amyotrophique (SLA). Elle apparait au niveau du cadre de lecture ouvert 72 du chromosome 9 (C9orf72).
openaire   +1 more source