Results 91 to 100 of about 12,907 (206)

New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin

Diabetes, Metabolic Syndrome and Obesity, 2010
Baptist GallwitzDept Medicine IV, Tübingen University, Otfried-Müller-Str, 10, 72076 Tübingen, GermanyAbstract: Saxagliptin is a novel dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) for the treatment of type 2 diabetes, with a duration
Gallwitz B
doaj   +2 more sources

The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies

Clinical Pharmacology: Advances and Applications, 2016
Melanie Davies,1,2 Sudesna Chatterjee,1,2 Kamlesh Khunti1,2 1Diabetes Research Centre, University of Leicester, 2Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK Abstract: Worldwide, an estimated 200 million people ...
Davies M, Chatterjee S, Khunti K
doaj  

Purification and Identification of Novel Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Bighead Carp (Hypophthalmichthys nobilis)

Foods
Dipeptidyl peptidase IV (DPP-IV) inhibitors are widely used in treating type 2 diabetes due to their ability to lower blood glucose levels. However, synthetic versions often lead to gastrointestinal side effects.
Hanzhi Zheng, Leyan Zhao, Yushuo Xie, Yuqing Tan   +3 more
doaj   +1 more source

The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity [PDF]

, 2002
Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes.
S. Wrenger, Reinhold, D., Brocke, S., S. Brocke, Steinbrecher, A., T. Kähne, D. Reinhold, Kähne, T., Neubert, K., A. Steinbrecher, K. Neubert, S. Ansorge, Wrenger, S., Ansorge, S.   +13 more
core   +1 more source

Heterocyclic Compounds as Dipeptidyl Peptidase-IV Inhibitors with Special Emphasis on Oxadiazoles as Potent Anti-Diabetic Agents. [PDF]

Molecules, 2022
Mohammad BD, Baig MS, Bhandari N, Siddiqui FA, Khan SL, Ahmad Z, Khan FS, Tagde P, Jeandet P.   +8 more
europepmc   +1 more source

Evaluation of (arene)Ru(II) complexes of curcumin as inhibitors of dipeptidyl peptidase IV [PDF]

, 2014
Curcumin, the main component of Curcuma longa, shows an anti-hyperglycemic effect and improved insulin sensitivity. This action may be attributed at least in part to its anti-inflammatory properties and also to its possible interaction with dipeptidyl ...
DE, ARPAN, LUPIDI, Giulio, E. Camaioni, VITALI, Luca Agostino, PETTINARI, Riccardo, MARCHETTI, Fabio, GIGLIOBIANCO, MARIA ROSA, PETTINARI, Claudio, A. Antonyan   +8 more
core   +1 more source

Suspected adverse drug reactions of the type 2 antidiabetic drug class dipeptidyl-peptidase IV inhibitors (DPP4i): Can polypharmacology help explain? [PDF]

Pharmacol Res Perspect, 2022
Jones L, Jones AM.
europepmc   +1 more source

Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]

, 2013
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Rory E Morty, Canning Peter, Rea, Dean, Dean Rea (483664), Morty Rory E., Morty, Rory E., Dean Rea, Vilmos Fülöp, Rory E. Morty (341515), Canning, Peter, Fülöp, Vilmos, Peter Canning, Peter Canning (483663), Vilmos Fülöp (483665), Rea Dean, Fülöp Vilmos   +15 more
core   +1 more source

Dipeptidyl-Peptidase-IV Inhibitors, Imigliptin and Alogliptin, Improve Beta-Cell Function in Type 2 Diabetes. [PDF]

Front Endocrinol (Lausanne), 2021
Liu X, Liu Y, Liu H, Li H, Yang J, Hu P, Xiao X, Liu D.   +7 more
europepmc   +1 more source

Data for: Optimization of the benzamide fragment targeting the S2’ site leads to potent Dipeptidyl Peptidase-IV inhibitors [PDF]

, 2019
Data for: Optimization of the benzamide fragment targeting the S2’ site leads to potent Dipeptidyl Peptidase-IV ...
Junhao Xing (5179799), Na Wang (193263), Linhong He (2287159), Junli Huang (466990), Qing Li (84975), Liuwei Meng (7519694), Siru Zhou (757724), Xiaoyan Deng (662989), Weizhe Jiang (695666)   +8 more
core   +1 more source