cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization [PDF]
, 2016 Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects.
R. Kirk McPherson (2201200) +19 more
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Mining of potential dipeptidyl peptidase-IV inhibitors as anti-diabetic agents using integrated in silico approaches [PDF]
, 2019 The dipeptidyl peptidase-IV (DPP-IV) family of receptors possesses a large binding cavity that imparts promiscuity for number of ligand binding which is not common to other receptors. This feature increases the challenge of using computational methods to
Shakir Ali (825218) +9 more
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Pyrazolidine Derivatives with Heteroaryl Urea as Dipeptidyl Peptidase IV Inhibitors
Chemical and Pharmaceutical Bulletin, 2005 In the continuation of efforts to modify the structure of our novel DP-IV inhibitors, a series of pyrazolidine derivatives with heteroaryl urea was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV).
Ahn, Jin Hee +10 more
openaire +3 more sources
Structure-based discovery of dipeptidyl peptidase IV inhibitors [PDF]
Structure-based discovery of dipeptidyl peptidase IV inhibitors. Diabetes afflicts approximately 151 million people worldwide, with an estimated increase to 221 million by 2010.
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D-420720, A Novel Orally Active Sulfonamide Compound Dipeptidyl Peptidase IV Inhibitor: Structure and Activity Relationship of Arylsuffonamide to Dipeptidyl Peptidase IV Inhibition [PDF]
, 2010 [[abstract]]Diabetes mellitus is a chronic disease characteristic of poor glucose homeostasis that requires constant monitoring and adjustment of blood glucose levels by exogenous intervention.
Tsai, HJ (Tsai, Henry J.); Chou, SY (Chou, Shan-Yen); Chuang, SH (Chuang, Shih-Hsien); Chen, CC (Chen, Chien-Cheng); Hsu, FL (Hsu, Feng-Lin)
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Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors [PDF]
, 2008 [[abstract]]To find potent and selective inhibitors of dipeptidyl peptidase IV (DPP-IV), we synthesized a series of 2-cyanopyrrolidine with P2-site 4-substituted glutamic acid derivatives and tested their activities against DPP-IV, DPP8, and DPP-II ...
Lu, IL; Lee, SJ; Tsu, H; Wu, SY; Kao, KH; Chien, CH; Chang, YY; Chen, YS; Cheng, JH; Chang, CN; Chen, TW; Chang, SP; Chen, X; Jiaang, WT
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Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety [PDF]
, 2016 Dipeptidyl peptidase IV (DPP-IV; E.C. 3.4.14.5), a serine protease that degrades the incretin hormones GLP-1 and GIP, is now a validated target for the treatment of type 2 diabetes.
William W. Bachovchin (1883854) +14 more
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A Real-world Comparative Analysis of DPP-4 Inhibitors Versus SGLT2 Inhibitors in Type 2 Diabetes Mellitus [PDF]
Pharmaceutical and Biomedical ResearchBackground: Diabetes has steadily increased in India over the last three decades, with 77 million people having diabetes as of 2019, which is expected to rise to 134 million by 2045. Over 90 % of these cases are of type 2 diabetes.
Parth Patel +4 more
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Mechanism of Action of Natural Dipeptidyl Peptidase-IV Inhibitors (Berberine and Mangiferin) in Experimentally Induced Diabetes with Metabolic Syndrome. [PDF]
Int J Appl Basic Med Res, 2023 Suman RK +3 more
europepmc +1 more source
Dipeptidyl peptidase IV inhibitors in diabetes: more than inhibition of glucagon-like peptide-1 metabolism? [PDF]
, 2008 Inhibitors of the protease dipeptidyl peptidase IV (DPP-IV) are promising new drugs for the treatment of type 2 diabetes. They are thought to act by inhibiting the breakdown of glucagon-like peptide-1 and, thereby, selectively enhancing insulin release ...
Eric Fliers +5 more
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