Results 81 to 90 of about 2,475,393 (270)

Associations Between Antidiabetic Pharmacotherapy and Hearing Thresholds in Adult Hearing-Impaired Patients With Type 2 Diabetes. [PDF]

Pharmacol Res Perspect
ABSTRACT Type 2 diabetes mellitus (T2DM) has increasingly been identified as a risk factor for sensorineural hearing loss, whereas the association between different antidiabetic therapies and hearing thresholds remains poorly characterized. This retrospective observational study evaluated 240 patients with T2DM and 105 normoglycemic controls who ...
Martines F, Salvago P, Vaccaro F, Vaccaro D, Malta G, Plescia F, Cascioferro S, Lavanco G, Plescia F.   +8 more
europepmc   +2 more sources

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors

, 2008
[[abstract]]Dipeptidyl peptidase IV (DPP-IV) is a valid drug target for type-2 diabetes and DPP-IV inhibitors have been proven to efficiently improve glucose tolerance.
Lu, IL;Tsai, KC;Chiang, YK;Jiaang, WT;Wu, SH;Mahindroo, N;Chien, CH;Lee, SJ;Chen, X;Chao, YS;Wu, SY
core   +1 more source

Dipeptidyl Peptidase-Iv Inhibitors: An Evolving Treatment for Type 2 Diabetes from the Incretin Concept

, 2008
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) are the 2 major incretin hormones released after meals to enhance glucose-stimulated insulin secretion.
CHYAN, YAU-JAN;CHUANG, LEE-MING, 錢瑤珍;莊立民   +1 more
core  

Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV [PDF]

, 2017
Two oxidovanadium(IV) complexes carrying Schiff base ligands obtained from the condensation of 4,5-dichlorobenzene-1,2-diamine and salicylaldehyde derivatives were synthesised and characterised, including their X-ray crystallographic structures.
Zhu, Ming-rong, Zhou, Jie, Jie Zhou, Hong-Ke Liu, Gao, Li-Hui, Sadler, P. J., Li, Ling, Ling Li, Carlos Sanchez-Cano, Yi Jin, Ming-jin Xie, Lu, Chun-Mei, Jin, Yi, Xie, Ming-jin, Peter J. Sadler, Chun-Mei Lu, Sanchez-Cano, Carlos, Li-Hui Gao, Liu, Hong-Ke, Fan-fang Li, Li, Fan-fang, Zhao, Qi Hua, Qi Hua Zhao, Ming-rong Zhu   +23 more
core   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

, 2016
The discovery of two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is described. After a single oral dose, these potent, selective, and noncovalent inhibitors provide sustained reduction of plasma
Michael B. Wallace (2235541), Bumsup Lee (2235517), Robert J. Skene (2235523), Lihong Shi (481066), Zhiyuan Zhang (93194), Kathleen Aertgeerts (1920946), Jun Feng (116162), Marc Navre (2235526), Stephen W. Kaldor (2235532), Stephen L. Gwaltney (2235514), Rongda Xu (2235529), Daniel B. Kassel (2235535), Andy Jennings (2235538), David R. Webb (200468), Jeffrey A. Stafford (2235520)   +14 more
core   +1 more source

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

A Real-world Comparative Analysis of DPP-4 Inhibitors Versus SGLT2 Inhibitors in Type 2 Diabetes Mellitus [PDF]

Pharmaceutical and Biomedical Research
Background: Diabetes has steadily increased in India over the last three decades, with 77 million people having diabetes as of 2019, which is expected to rise to 134 million by 2045. Over 90 % of these cases are of type 2 diabetes.
Parth Patel, Xama Patel, Zankrut Patel, Akanksha Prajapati, Sumit Patel   +4 more
doaj  

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin

Diabetes, Metabolic Syndrome and Obesity, 2010
Baptist GallwitzDept Medicine IV, Tübingen University, Otfried-Müller-Str, 10, 72076 Tübingen, GermanyAbstract: Saxagliptin is a novel dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) for the treatment of type 2 diabetes, with a duration
Gallwitz B
doaj   +2 more sources