Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. [PDF]
, 2014 The successful launches of dipeptidyl peptidase IV (DPP IV) inhibitors as oral anti-diabetics warrant and spur the further quest for additional chemical entities in this promising class of therapeutics.
Trappe, Joerg +15 more
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Acute Kidney Injury Associated with Linagliptin
Case Reports in Endocrinology, 2016 Linagliptin is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that is approved for the treatment of type 2 diabetes mellitus. About 5% of linagliptin is eliminated by the kidneys and no dose adjustment is recommended in kidney impairment. We report a first
Deepak K. Nandikanti +2 more
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Acta Pharmaceutica, 2021 Diabetes mellitus is a chronic illness that needs persistent medical attention and continuous patient self-management to avoid acute complications. Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the ...
Khalaf Reema Abu +2 more
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Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.
Ensho, 1998 Dipeptidyl peptidase IV (DP IV, CD26) is a serine exopeptidase which selectively cleaves the penultimate proline residue of polypeptides. This enzyme is also expressed on activated T cells. To assess the relevance of DP IV in immunological disorders, we evaluated the pharmacological effects of specific DP IV inhibitors. A competitive inhibitor of DP IV,
Tanaka, Sumiko, Sugita, Takahisa
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Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors [PDF]
, 2009 [[abstract]]A series of (2S)-cyanopyrrolidines with glutamic acid derivatives at the P2 site have been prepared and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV).
Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Chiou, MC;Huang, CH;Tseng, YJ;Yeh, TK;Huang, CY;Yeh, KC;Huang, YW;Wu, SH;Wang, MH;Chen, X;Chao, YS;Jiaang, WT
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Frontiers in Endocrinology, 2022 Type 2 diabetes mellitus is a metabolic disorder resulting from impaired insulin secretion and resistance. Dipeptidyl peptidase (DPP)-IV is an enzyme known to trigger the catalysis of insulinotropic hormones, further abating the endogenous insulin levels
Srishti Chhabria +8 more
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Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats [PDF]
, 2016 Rajesh Kumar Suman,1 Ipseeta Ray Mohanty,1 Ujwala Maheshwari,2 Manjusha K Borde,1 YA Deshmukh1 1Department of Pharmacology, 2Department of Pathology, MGM Medical College, Kamothe, Navi Mumbai, India Background: Mangiferin (MNG) is known to possess ...
Borde MK +4 more
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A Novel Orally Active Sulfonamide Compound Dipeptidyl Peptidase IV Inhibitor: Structure and Activity Relationship of Arylsulfonamide to Dipeptidyl Peptidase IV Inhibition [PDF]
, 2012 [[abstract]]Diabetes mellitus is a chronic disease characteristic of poor glucose homeostasis that requires constant monitoring and adjustment of blood glucose levels by exogenous intervention.
蔡建鈞;Tsai, Henry J;Chou, Shan-Yen;Chuang, SH;Chen, CC;Hsu, FL
core
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV [PDF]
, 2017 Two oxidovanadium(IV) complexes carrying Schiff base ligands obtained from the condensation of 4,5-dichlorobenzene-1,2-diamine and salicylaldehyde derivatives were synthesised and characterised, including their X-ray crystallographic structures.
Zhu, Ming-rong +23 more
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Efficacy of Body Weight Reduction on the SGLT2 Inhibitor in People with Type 2 Diabetes Mellitus
Journal of Obesity & Metabolic Syndrome, 2017 Background : Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have demonstrated efficacy of dapagliflozin for type 2 diabetic patients ...
Hyun A Cho +7 more
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