Results 71 to 80 of about 22,239 (295)

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

2. tüüpi diabeedi ravimid IV: DPP-4 inhibiitorid [PDF]

, 2009
DPP-4 inhibiitorid ehk gliptiinid on kõige uuem ravimrühm 2. tüüpi diabeedi ravis.
Volke, Vallo
core   +2 more sources

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

Screening and analysis of malt pentapeptide DPP-IV inhibitory activity

npj Science of Food
Type 2 diabetes mellitus (T2DM) poses a significant global health burden, with dipeptidyl peptidase-IV (DPP-IV) inhibitors being critical therapeutic targets for its management.
Yi He, Yan Zhang, Pengying Zhang, Jiaying Li, Wannan Li, Weiwei Han   +5 more
doaj   +1 more source

Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.

Ensho, 1998
Dipeptidyl peptidase IV (DP IV, CD26) is a serine exopeptidase which selectively cleaves the penultimate proline residue of polypeptides. This enzyme is also expressed on activated T cells. To assess the relevance of DP IV in immunological disorders, we evaluated the pharmacological effects of specific DP IV inhibitors. A competitive inhibitor of DP IV,
Sumiko Tanaka, Takahisa Sugita
openaire   +2 more sources

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

A comparative study of an aminopeptidase from lactic acid bacteria: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1992
Aminopeptidase enzymes from the proteolytic systems of S.salivarius subsp.thermophilus Lactococcus lactis subsp.cremoris and Lactococcus lactis subsp.lactis have been investigated.
Midwinter, Robyn Gillian
core  

Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes [PDF]

, 2017
Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients.
Fernandes, Rosa, Lemos, Edite Teixeira de, Mega, Cristina, Reis, Flávio   +3 more
core   +3 more sources

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Controversy about the relative efficacy of dipeptidyl peptidase IV inhibitors [PDF]

Diabetologia, 2012
To the Editor: The position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recently published an updated algorithm for the initiation and adjustment of therapy for the management of hyperglycaemia in type 2 diabetes [1].
openaire   +2 more sources