Results 11 to 20 of about 12,220 (249)
Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis [PDF]
Endocrinology and Metabolism, 2023 Background The effects of dipeptidyl peptidase 4 (DPP-4) inhibitors over the course of long-term treatment remain unclear, and concerns have been raised regarding the role of DPP-4 inhibitors in carcinogenesis in the pancreas.
Mee Kyoung Kim +3 more
doaj +1 more source
Vildagliptin induced cutaneous leukocytoclastic vasculitis: A case report
Medicine Science, 2018 Vildagliptin is a new generation theurapeutic agent of diabetes mellitus which belongs to dipeptidyl peptidase-IV inhibitor class acting via the incretin hormone system.
Serhat Sayin +2 more
doaj +1 more source
Endocrinology, Diabetes & Metabolism, 2021 Introduction We evaluated the efficacy and safety of teneligliptin compared with placebo when added to metformin therapy in Chinese patients with type 2 diabetes inadequately controlled with metformin monotherapy.
Linong Ji +10 more
doaj +1 more source
Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice
Scientific Reports, 2021 Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral.
Henrik H. Hansen +8 more
doaj +1 more source
Current Research in Food Science, 2021 There is emerging evidence on the importance of food-derived bioactive peptides to promote human health. Compared with animal derived proteins, plant proteins, in particular oilseed proteins, are considered as affordable and sustainable sources of ...
Ruixian Han +4 more
doaj +1 more source
Lechenie sakharnogo diabeta 2 tipa ingibitorami dipeptidilpeptidazy-4
Ожирение и метаболизм, 2010 Type 2 diabetes is difficult to manage and multiple therapeutic approach are usually needed. Moreover, addition to the initial treatment of most currently available oral antidiabetic agents increases the risk of hypoglycaemia and causes a weight gain ...
doaj +1 more source
Synthesis and antidiabetic activity of β-acetamido ketones
Acta Pharmaceutica Sinica B, 2011 This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst.
Xing-hua Zhang +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2008 An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into ...
Santosh K. Singh +2 more
doaj +1 more source
An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor [PDF]
Pharmacia, 2023 During an ethnopharmacology study of traditional antidiabetic treatment in Gunung Sari village, Bogor region, Indonesia, fifteen traditional medicinal plants were selected, collected and prepared as crude extracts. Among fifteen plants, only three plants
Greesty Finotory Swandiny +6 more
doaj +3 more sources