Results 31 to 40 of about 12,907 (206)
Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice
Scientific Reports, 2021 Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral.
Henrik H. Hansen +8 more
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Current Research in Food Science, 2021 There is emerging evidence on the importance of food-derived bioactive peptides to promote human health. Compared with animal derived proteins, plant proteins, in particular oilseed proteins, are considered as affordable and sustainable sources of ...
Ruixian Han +4 more
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Lechenie sakharnogo diabeta 2 tipa ingibitorami dipeptidilpeptidazy-4
Ожирение и метаболизм, 2010 Type 2 diabetes is difficult to manage and multiple therapeutic approach are usually needed. Moreover, addition to the initial treatment of most currently available oral antidiabetic agents increases the risk of hypoglycaemia and causes a weight gain ...
doaj +1 more source
Synthesis and antidiabetic activity of β-acetamido ketones
Acta Pharmaceutica Sinica B, 2011 This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst.
Xing-hua Zhang +4 more
doaj +1 more source
Novel compounds as dipeptidyl peptidase IV (dpp iv) inhibitors [PDF]
, 2009 The present invention is related to novel compounds of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds ...
Hajare, Anil +10 more
core +4 more sources
Beilstein Journal of Organic Chemistry, 2008 An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into ...
Santosh K. Singh +2 more
doaj +1 more source
Dipeptidyl-Peptidase IV inhibitors and glycemic control in type 2 Diabetes Mellitus
Journal of College of Medical Sciences-Nepal, 2016 Background & Objectives: Type 2 diabetes mellitus (T2DM) is a progressive disease, characterized by insulin resistance, impaired glucose-induced insulin secretion, inappropriately elevated glucagon concentrations, and hyperglycemia.
Lokendra Bahadur Sapkota, Sangita Thapa
doaj +1 more source
An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor [PDF]
Pharmacia, 2023 During an ethnopharmacology study of traditional antidiabetic treatment in Gunung Sari village, Bogor region, Indonesia, fifteen traditional medicinal plants were selected, collected and prepared as crude extracts. Among fifteen plants, only three plants
Greesty Finotory Swandiny +6 more
doaj +3 more sources
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes. [PDF]
, 2005 Udgivelsesdato: 2006-nullGlucagon-like peptide-1 is an insulinotropic hormone with antidiabetic potential due to its spectrum of effects, which include glucose-dependent stimulation of insulin and inhibition of glucagon secretion, tropic effects on the ...
Holst, Jens J, Deacon, Carolyn F
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Synthesis, Evaluation and Molecular Docking of Prolyl‐Fluoropyrrolidine Derivatives as Dipeptidyl Peptidase IV Inhibitors [PDF]
, 2013 A series of prolyl‐fluoropyrrolidine derivatives were designed, synthesized and screened for in vitro inhibition of dipeptidyl peptidase IV. The SAR study revealed the influence of substituted chemical modifications on dipeptidyl peptidase IV inhibitory ...
Kumar, Manoj +4 more
core +1 more source