Results 21 to 30 of about 2,475,393 (270)

Synthesis and antidiabetic activity of β-acetamido ketones

Acta Pharmaceutica Sinica B, 2011
This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst.
Xing-hua Zhang, Ju-fang Yan, Li Fan, Gong-bao Wang, Da-cheng Yang   +4 more
doaj   +1 more source

The study of a new and specific proline cleaving peptidase from bovine serum [PDF]

, 2003
Prolyl oligopeptidase is a serine peptidase characterised by oligoendopeptidase activity. Definitive evidence for the discrete biological role of prolyl oligopeptidase remains unknown, though its role in the maturation and degradation of peptide hormones
Collins, Patrick
core   +1 more source

Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: A key intermediate for dipeptidyl peptidase IV inhibitors

Beilstein Journal of Organic Chemistry, 2008
An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into ...
Santosh K. Singh, Narendra Manne, Manojit Pal   +2 more
doaj   +1 more source

Dipeptidyl-Peptidase IV inhibitors and glycemic control in type 2 Diabetes Mellitus

Journal of College of Medical Sciences-Nepal, 2016
Background & Objectives: Type 2 diabetes mellitus (T2DM) is a progressive disease, characterized by insulin resistance, impaired glucose-induced insulin secretion, inappropriately elevated glucagon concentrations, and hyperglycemia.
Lokendra Bahadur Sapkota, Sangita Thapa
doaj   +1 more source

An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor [PDF]

Pharmacia, 2023
During an ethnopharmacology study of traditional antidiabetic treatment in Gunung Sari village, Bogor region, Indonesia, fifteen traditional medicinal plants were selected, collected and prepared as crude extracts. Among fifteen plants, only three plants
Greesty Finotory Swandiny, Gian Primahana, Muhammad Eka Prastya, Novita Ariani, Deny Susanti, Muhammad Hanafi, Syamsudin Abdillah   +6 more
doaj   +3 more sources

Phosphoinositide-specific phospholipase C inhibition data using the dipeptidyl peptidase-IV inhibitors K-579 and LAF-237

, 2014
Data set for Fig 2 in the main article, describing the inhibition of Phosphoinositide-specific phospholipase C inhibition using the dipeptidyl peptidase-IV inhibitors K-579 and LAF-237.Peer ...
Chakraborty, Sandeep, Dutta, Mouparna, Ásgeirsson, Bjarni, Rendón Ramírez, Adela, Ghosh, Anindya S., Rao, Basuthkar J., Dandekar, Abhaya M., Venkatramani, Ravindra, Oda, Masataka, Goñi, Félix M.   +9 more
core   +2 more sources

Dipeptidyl peptidase IV inhibitors derived from a mangrove flora Rhizophora mucronata: An in silico approach

Bangladesh Journal of Pharmacology, 2012
Dipeptidyl peptidase IV (DPP IV) is responsible for conversion of glucose tolerance (GLP-1), into inactive form. The inhibition of DPP IV would be beneficial in the treatment of diabetes mellitus.
Selvaraj Gurudeeban, Kaliyamurthi Satyavani, Thirugnanasambandam Ramanathan, Palanisamy Ravikumar   +3 more
doaj   +1 more source

Novel compounds as dipeptidyl peptidase IV (dpp iv) inhibitors [PDF]

, 2009
The present invention is related to novel compounds of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds ...
Hajare, Anil, Patil, Pravin, Swamy, K.H. Sreedhara, Kamboj, Rajender Kumar, Chakka, Sai Kumar, Sayyed, Majid, Goel, Rajan, Reddy, Azmi, Sinha, Neelima, Patil, Pravin; id_orcid, Arora, Sudershan, Nair, Prathap   +11 more
core   +4 more sources

DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses

Molecules, 2018
Dipeptidyl peptidase IV (DPP-IV), a new target for the treatment of type 2 diabetes mellitus, degrades incretins such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide. DPP-IV inhibitors shorten the inactivation of GLP-1,
Bo-Ram Kim, Hyo Young Kim, Inhee Choi, Jin-Baek Kim, Chang Hyun Jin, Ah-Reum Han   +5 more
doaj   +1 more source

Characterization of Novel Dipeptidyl Peptidase-IV Inhibitory Peptides from Soft-Shelled Turtle Yolk Hydrolysate Using Orthogonal Bioassay-Guided Fractionations Coupled with In Vitro and In Silico Study

Pharmaceuticals, 2020
Five novel peptides (LPLF, WLQL, LPSW, VPGLAL, and LVGLPL) bearing dipeptidyl peptidase IV (DPP-IV) inhibitory activities were identified from the gastrointestinal enzymatic hydrolysate of soft-shelled turtle yolk (SSTY) proteins.
Nhung Thi Phuong Nong, Yu-Kuo Chen, Wen-Ling Shih, Jue-Liang Hsu   +3 more
doaj   +1 more source