Results 231 to 240 of about 22,026 (263)
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A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors
European Journal of Medicinal Chemistry, 2008Dipeptidyl peptidase IV (DPP-IV) is a valid drug target for type-2 diabetes and DPP-IV inhibitors have been proven to efficiently improve glucose tolerance. In our study, 3D pharmacophore models were generated using a training set of 22 DPP-IV inhibitors.
I-Lin, Lu +10 more
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Population Pharmacokinetic/Pharmacodynamic Modelling of Dipeptidyl Peptidase IV Inhibitors
Clinical Pharmacokinetics, 2015The prevalence of type 2 diabetes has dramatically increased over the past decades, causing high morbidity, mortality and healthcare costs. Dipeptidyl peptidase IV (DPP-4) inhibitors, also called ‘gliptins’, are a relatively new group of antidiabetic agents that target the incretin system.
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Inhibitors of Dipeptidyl Peptidase IV - Recent Advances and Structural Views
Current Topics in Medicinal Chemistry, 2005Prevalence of type 2 diabetes has increased dramatically in the last decades. Current medicines are not yet capable to efficiently prevent or reverse progression of the disease and its associated comorbidities. As a consequence, there is a great need for novel antidiabetic drugs.
Daniel, Hunziker +2 more
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Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Letters, 2012Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
Betty, Lam +5 more
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New Fluorinated Pyrrolidine and Azetidine Amides as Dipeptidyl Peptidase IV Inhibitors.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Bernard, Hulin +5 more
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Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease
New England Journal of Medicine, 2021Sherif S Farag +2 more
exaly
Novel compounds as dipeptidyl peptidase IV (dpp iv) inhibitors
2009The present invention is related to novel compounds of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or ...
Arora, Sudershan +10 more
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Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage
Molecular Cell, 2021A Manuel Liaci +2 more
exaly