Results 111 to 120 of about 58,085 (295)

A Dipeptidyl Peptidase-4 Inhibitor but not Incretins Suppresses Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice.

Journal of atherosclerosis and thrombosis, 2016
AIM The main pathophysiology of abdominal aortic aneurysm (AAA) considerably overlaps with that of atherosclerosis. We reported that incretins [glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP)] or a dipeptidyl ...
Kyoko Kohashi, Munenori Hiromura, Y. Mori, Michishige Terasaki, Takuya Watanabe, Hideki Kushima, Kyoko Shinmura, Masako Tomoyasu, Masaharu Nagashima, T. Hirano   +9 more
semanticscholar   +1 more source

A self-compartmentalizing hexamer serine protease from Pyrococcus Horikoshii: Substrate selection achieved through multimerization [PDF]

, 2013
Oligopeptidases impose a size limitation on their substrates, the mechanism of which has long been in debate. Here we present the structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revealing a complex, self ...
Aertgeerts, Afonine, Anna Kiss-Szemán, Balázs Hornung, Biswal, Bjelkmar, Bosch, Cha, Chen, Chiti, Clark, Collaborative Computational Project, Number 4, Cowtan, Dobson, Duysen, Dóra K. Menyhárd, Eldrup, Emsley, Engel, Engel, Erlandsson, Franken, Fuxreiter, Fülöp, Goettig, Gábor Náray-Szabó, Harmat, Hess, Hiramatsu, Hofmann, Ilona Szamosi, Joshua-Tor, Juhász, Kabsch, Kim, Kim, Kiss, Kiss, Klarissza Domokos, Krisztina Rádi, Li, László Polgár, Mackerell, Maurer-Stroh, McLuskey, Medrano, Monincová, Monsellier, Murshudov, Naylor, Palmieri, Pathak, Polgár, Prokop, Richards, Richardson, Rould, Scaloni, Schmidt, Shan, Shan, Sheldrick, Soldi, Stefani, Szeltner, Szeltner, Szeltner, Thoms, Vagin, Vaguine, Veronika Harmat, Zhang, Zoltán Szeltner, Éva Tichy-Rács   +73 more
core   +1 more source

The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin functions as antioxidant on human endothelial cells exposed to chronic hyperglycemia and metabolic high-glucose memory

Endocrine, 2016
Dipeptidyl peptidase-4 inhibitors are widely used in type 2 diabetes. Endothelium plays a crucial role maintaining vascular integrity and function.
G. Pujadas, V. De Nigris, F. Prattichizzo, L. La Sala, R. Testa, A. Ceriello   +5 more
semanticscholar   +1 more source

Teneligliptin in management of type 2 diabetes mellitus

Diabetes, Metabolic Syndrome and Obesity, 2016
Surendra Kumar Sharma,1 A Panneerselvam,2 KP Singh,3 Girish Parmar,4 Pradeep Gadge,5 Onkar C Swami6 1Diabetes, Thyroid and Endocrine Centre, Galaxy Speciality Centre, Jaipur, 2Aruna Diabetes Centre, Chennai, 3Fortis Hospital, Sector 62, Phase VIII ...
Sharma SK, Panneerselvam A, Singh KP, Parmar G, Gadge P, Swami OC   +5 more
doaj  

Time to exacerbation of heart failure is longer in Malaysian population on dipeptidyl peptidase-4 inhibitor

Heart India, 2017
Context: Diabetes mellitus is a recognized risk factor for heart failure. Dipeptidyl peptidase-4 inhibitors (DPP4i) are used in patients with diabetes largely due to its efficacy in glycated hemoglobin (HbA1c) reduction, neutral weight effect, and lower ...
J Hasan, R Najme Khir, M A Saman, K S Ibrahim, J R Ismail, R A Ghani, C W Lim, Z Ibrahim, E A Rahman, N Chua, HAZ Abidin, MKM Arshad, S Kasim   +12 more
doaj   +1 more source

Direct cardiovascular effects of glucagon like peptide-1 [PDF]

, 2013
Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use of traditional anti-diabetic drugs, in most cases, does not significantly reduce macrovascular ...
Asfandyar Sheikh
core   +1 more source

Which is better, high‐dose metformin monotherapy or low‐dose metformin/linagliptin combination therapy, in improving glycemic variability in type 2 diabetes patients with insufficient glycemic control despite low‐dose metformin monotherapy? A randomized, cross‐over, continuous glucose monitoring‐based pilot study

Journal of Diabetes Investigation, 2019
Aims/Introduction The present study investigated the effect of high‐dose metformin or low‐dose metformin/linagliptin combination therapy on glycemic variability (GV) in type 2 diabetes patients with insufficient glycemic control despite low‐dose ...
Hiroshi Takahashi, Rimei Nishimura, Daisuke Tsujino, Kazunori Utsunomiya   +3 more
doaj   +1 more source

Studi Qsar Senyawa Turunan Triazolopiperazin Amida sebagai Inhibitor Enzim Dipeptidil Peptidase-IV (DPP IV) Menggunakan Metode Semiempirik AM1 [PDF]

, 2013
Studi QSAR (Quatitative Structure-Activity Relationship) telah dilakukan untuk senyawa turunan triazolopiperazin amida sebagai inhibitor enzim DPP IV (dipeptidil peptidase-IV) yang merupakan penyebab diabetes melitus tipe 2.
Asmara, A. P. (Anjar), Mudasir, M. (Mudasir), Siswanta, D. (Dwi)   +2 more
core  

Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis [PDF]

, 2017
IntroductionDipeptidyl peptidase-4 (DPP-4) inhibitors reduce blood glucose in a dose-dependent manner, but the dose-dependent effect relationship between DPP-4 inhibitors and atherosclerosis has not been investigated.MethodsPatients with type 2 diabetes ...
Gosho Masahiko, Katakami Naoto, Mita Tomoya, Shimomura Iichiro, Shiraiwa Toshihiko, Watada Hirotaka, Yoshii Hidenori, 五所 正彦   +7 more
core   +1 more source

Review for "Lower Cardiorenal Risk with Sodium-Glucose Cotransporter-2 Inhibitors versus Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Patients without Cardiovascular and Renal Diseases: A large multinational observational study"

, 2020

openalex   +2 more sources