Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4 [PDF]
, 2023 Francisco Alejandro Lagunas‐Rangel +5 more
openalex +1 more source
WONOEP XVII appraisal: The immunopathogenesis of epilepsy
Epilepsia, EarlyView.Abstract There is a wealth of data indicating that the immune system plays an important role in seizure disorders. This includes autoimmune encephalitis, in which an immune response directed against neuronal antigens results in brain inflammation and subsequent seizure activity, as well as autoimmune‐associated epilepsy and neuroinflammatory changes ...
Nihan Çarçak +12 more
wiley +1 more source
Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice [PDF]
, 2021 Cayasso, Mayella +6 more
core +1 more source
Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, EarlyView.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Dipeptidyl Peptidase 4 Inhibitors: Therapeutic Options
Effective PharmacotherapyDipeptidyl peptidase 4 inhibitors are a new innovative class of glucose-lowering drugs. The drugs belong to the group of incretin mimetics, prolonging the action of their own incretins. Since 2007, the list of proposed dipeptidyl peptidase 4 inhibitors has expanded significantly and significant experience in their use has accumulated.
S.V. Podachina, I.V. Soloviova
openaire +1 more source
Studi Qsar Senyawa Turunan Triazolopiperazin Amida sebagai Inhibitor Enzim Dipeptidil Peptidase-IV (DPP IV) Menggunakan Metode Semiempirik AM1 [PDF]
, 2013 Studi QSAR (Quatitative Structure-Activity Relationship) telah dilakukan untuk senyawa turunan triazolopiperazin amida sebagai inhibitor enzim DPP IV (dipeptidil peptidase-IV) yang merupakan penyebab diabetes melitus tipe 2.
Asmara, A. P. (Anjar) +2 more
core
The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa
The FEBS Journal, EarlyView.Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte +9 more
wiley +1 more source
Efficacy and safety of bi-weekly cofrogliptin treatment replacing daily dipeptidyl peptidase-4 inhibitors in Chinese patients with type 2 diabetes mellitus: A multicenter, open-label, randomized controlled phase 2 trial. [PDF]
Diabetes Obes MetabAbstract Aim This study aimed to investigate the efficacy and safety of bi‐weekly cofrogliptin treatment as a replacement for daily dipeptidyl peptidase‐4 inhibitors (DPP‐4is) in Chinese patients with type 2 diabetes mellitus (T2DM). Methods This multicenter, open‐label, randomized controlled study assigned participants in a 1:1 ratio to either the ...
Pan C +10 more
europepmc +2 more sources