Results 1 to 10 of about 8,953 (160)

Novel Diffuse Midline Glioma-on-Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies. [PDF]

Small
In this work, a DMG‐on‐Chip (DoC) is set up, with a geometry yielding gradients of nutrient and oxygen depletion, to recapitulate this trait of tumor microenvironment‐driven heterogeneity. The biophysical and biochemical characterization of this microsystem via fluorescence microscopy analyses highlights the acidification of the tumor core, along with ...
Terrassoux L, Hazard C, Laratte A, Balsamelli J, Arcicasa M, Fong E, Baland L, Soncin F, Cappello G, Maurage CA, Janel S, Bazir A, Cleri F, Treizebre A, Lartigau E, Rekik Y, Meignan S, Furlan A.   +17 more
europepmc   +2 more sources

FUS BBBO with a Portable FUS System and real time mapping [PDF]

Alzheimers Dement
Abstract Background Treatment of neurological diseases has been at the forefront of medical research for more than a century with limited success due partly to the blood‐brain barrier (BBB) that impedes both delivery and biodistribution of the drug delivered.
Konofagou E.
europepmc   +2 more sources

Raphin-1 mediates the survival and sensitivity to radiation of pediatric-type diffuse high-grade glioma via phosphorylated eukaryotic initiation factor 2α-dependent and -independent processes. [PDF]

Mol Oncol
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Eytan K, Leitner M, Toren A, Paglin S, Yalon M.   +4 more
europepmc   +2 more sources

DIPG-74. RE-IRRADIATION OF DIPG: DATA FROM THE INTERNATIONAL DIPG REGISTRY [PDF]

Neuro-Oncology, 2020
Abstract PURPOSE To review data from DIPG Registry patients recorded to have received a second course of radiation therapy (rRT). METHODS The International DIPG Registry was searched for patients with DIPG who were treated with a ...
Lafay-Cousin, Lucie, Lane, Adam, Schafer, Austin, Saab, Raya, Cheng, Sylvia, Bandopadhayay, Pratiti, Zaghloul, Mohamed, El-Ayadi, Motasem, Dorris, Kathleen, Packer, Roger, Kilburn, Lindsey, Minturn, Jane, Dodgshun, Andrew, Parkin, Sara, Lombardi, Mercedes Garcia, Cohen, Kenneth, Gass, David, Goldman, Stewart, Sandler, Eric, Warren, Katherine, Greiner, Robert, Gottardo, Nicholas, Dholaria, Hetal, Hassall, Tim, Coven, Scott, Hansford, Jordan, Samson, Yvan, Leary, Sarah, Bartels, Ute, Bouffet, Eric, Ma, Jie, Tinkle, Christopher, Monje-Deisseroth, Michelle, Fisher, Paul, Tsui, Karen, Ziegler, David, Chintagumpala, Murali, Gururangan, Sridharan, Wagner, Lars, Koschmann, Carl, DeWire-Schottmiller, Mariko, Leach, James, Jones, Blaise, Fuller, Christine, Drissi, Rachid, Chaney, Brooklyn, Black, Katie, Fouladi, Maryam, Strother, Douglas   +48 more
openaire   +1 more source

DIPG-70. DISORDERED DNA METHYLATION IN DIPG UNDERLIES PHENOTYPIC PLASTICITY [PDF]

Neuro-Oncology, 2020
Abstract Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a dismal prognosis and no effective treatment. Recent studies point to a critical role for epigenetic dysregulation in this disease. Nearly 80% of DIPGs harbor mutations in histone H3 encoding replacement of lysine 27 with methionine (K27M), leading to ...
Koldobskiy, Michael, Tetens, Ashley, Martin, Allison, Eberhart, Charles, Raabe, Eric, Goutsias, John, Feinberg, Andrew   +6 more
openaire   +1 more source

DIPG-03. Therapeutic targeting of purine biosynthesis in DIPG

Neuro-Oncology, 2022
Abstract Diffuse intrinsic pontine glioma (DIPG) is an incurable brainstem malignancy in children. Little progress has been made in treating this deadly disease due to its inoperable location and treatments aimed at targets defined in adult gliomas.
Mersich, Ian, Dasgupta, Biplab
openaire   +1 more source

DIPG-16. Evaluation of myeloid component of DIPG microenvironment

Neuro-Oncology, 2022
Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable disease of the central nervous system in children with median overall survival of less than one year. In recent years, several immunotherapy strategies have emerged as an option to treat DIPG.
Mishra, Deepak, Rajendran, Sakthi, Zhu, Xiaoting, Nazzaro, Matthew, Kumar, Shiva Senthil, Mchugh, Todd, Rajappa, Prajwal, Drissi, Rachid   +7 more
openaire   +1 more source

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
core   +7 more sources

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus. [PDF]

, 2017
Modified measles virus (MV) has effective oncolytic activity preclinically and is currently being investigated in clinical trials for various types of cancer. We investigated the use of cystine knot proteins (CKPs) to direct MV activity.
Lal, Sangeet, Raffel, Corey
core   +6 more sources

DIPG-46. NON-DIPG PATIENTS ENROLLED IN THE INTERNATIONAL DIPG REGISTRY: HISTOPATHOLOGIC EVALUATION OF CENTRAL NEURO-IMAGING REVIEW [PDF]

Neuro-Oncology, 2020
Abstract INTRODUCTION The role of diagnostic biopsy in diffuse intrinsic pontine glioma (DIPG) remains in question. Distinguishing radiographically between DIPG and other pontine tumors with more favorable prognosis and different therapy is critically important.
Lazow, Margot A, Fuller, Christine, Lane, Adam, DeWire-Schottmiller, Mariko D, Bandopadhayay, Pratiti, Bartels, Ute, Bouffet, Eric, Cheng, Sylvia, Cohen, Kenneth J, Cooney, Tabitha M, Coven, Scott L, Dholaria, Hetal, Diez, Blanca, Dorris, Kathleen, El-Ayadi, Motasem, El-Sheikh, Ayman, Fisher, Paul G, Lombardi, Mercedes Garcia, Greiner, Robert J, Goldman, Stewart, Gottardo, Nicholas, Gururangan, Sridharan, Hansford, Jordan R, Hassall, Tim, Hawkins, Cynthia, Kilburn, Lindsay, Koschmann, Carl J, Leary, Sarah E, Ma, Jie, Minturn, Jane E, Monje-Deisseroth, Michelle, Packer, Roger J, Samson, Yvan, Sandler, Eric S, Sevlever, Gustavo, Tinkle, Christopher, Tsui, Karen, Wagner, Lars M, Zaghloul, Mohamed, Ziegler, David S, Chaney, Brooklyn, Black, Katie, Asher, Anthony, Drissi, Rachid, Fouladi, Maryam, Jones, Blaise V, Leach, James L   +46 more
openaire   +1 more source