Results 11 to 20 of about 8,953 (160)

DIPG-57. TRANSCRIPTOMIC AND PROTEOMIC ANALYSES OF DIPG RESPONSE TO ONC201 [PDF]

Neuro-Oncology, 2020
Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable pediatric brain tumor. Current standard of care has shown no improvements in survival. Here, we report our study of ONC201, a first-in-class small molecule developed by Oncoceutics, Inc., against a panel of DIPG cells in vitro and in mouse orthotopic models. ONC201 inhibits
Sridharan, Sreepradha, Harmanci, Arif, Sharma, Ajay, Lai, Yanlai, Kennis, Bridget, Dobson, Tara, Swaminathan, Jyothishmathi, Haltom, Amanda, Khatua, Soumen, Tarapore, Rohinton, Allen, Joshua, Cheng, Donghang, Zaky, Wafik, Gopalakrishnan, Vidya   +13 more
openaire   +1 more source

DIPG-48. DIPG THROUGH THE LOOKING GLASS

Neuro-Oncology, 2023
Abstract Diffuse intrinsic pontine glioma (DIPG) has a peculiar pathogenesis with canonical Histone variants H3.1/H3.2 wherein Lysine 27 (H3K27) is substituted to methionine (H3K27M). It is restricted to pons and affects young children whereas non canonical H3.3 mutations result in tumours across the midline and affects older children ...
openaire   +1 more source

DIPG-30. DIFFERENTIAL HYPOXIC RESPONSE IN HUMAN DIPG CELL LINES [PDF]

Neuro-Oncology, 2017
BACKGROUND: Diffuse Intrinsic Pontine Glioma (DIPG) are rare and aggressive childhood tumors, with an abysmal prognosis and limited experimental models available for study. A recent report showed that DIPG are hypoperfused compared to surrounding brain tissue, suggesting that the tumor cells are exposed to a hypoxic microenvironment.
Waker, Christopher A., Shahin, Maryam, Kamian, Aria, Lober, Zoe, Lober, Robert M.   +4 more
openaire   +2 more sources

DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG [PDF]

Neuro-Oncology, 2020
Abstract DIPG is a universally fatal pediatric brainstem tumor with no effective therapy. Recent work has shown that over 80% of DIPG cases harbor the H3K27M mutation leading to global loss of the repressive H3K27 trimethylation mark, global DNA hypomethylation, and a distinct gene expression signature.
Tetens, Ashley, Martin, Allison, Arnold, Antje, Novak, Orlandi, Eberhart, Charles, Feinberg, Andrew, Raabe, Eric, Koldobskiy, Michael   +7 more
openaire   +1 more source

DIPG-40. TARGETING MASTER REGULATOR DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) [PDF]

Neuro-Oncology, 2020
Abstract Diffuse intrinsic pontine glioma (DIPG) remains a fatal disease with no effective drugs to date. Mutation-based precision oncology approaches are limited by lack of targetable mutations and genetic heterogeneity. We leveraged systems biology methodologies to discover common targetable disease drivers—master regulator proteins ...
Pavisic, Jovana, Sethi, Chankrit, Jones, Chris, Zacharoulis, Stergios, Califano, Andrea   +4 more
openaire   +1 more source

DIPG-59. UPREGULATION OF PRENATAL PONTINE ID1 SIGNALING IN DIPG

Neuro-Oncology, 2020
Abstract BACKGROUND Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors with no curative therapies. Inhibitor of DNA binding (ID) proteins are key regulators of gene differentiation during embryogenesis.
Harris, Micah K, Yadav, Viveka Nand, Stallard, Stefanie, Woo, Rinette, Siddaway, Robert, Qin, Tingting, Mullan, Brendan, Miklja, Zachary, Siada, Ruby, Ravindran, Ramya, Cao, Xuhong, Pasternak, Amy, Castro, Maria G, Lowenstein, Pedro R, Mody, Rajen, Chinnaiyan, Arul, Hawkins, Cynthia, Desprez, Pierre, McAllister, Sean, Venneti, Sriram, Koschmann, Carl   +20 more
openaire   +1 more source

Diffuse intrinsic pontine glioma biopsy: A single institution experience [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109626/1/pbc25224 ...
Altinok, Deniz, Bhambhani, Kanta, Miller, Kathy, Poulik, Janet, Rao, Latha, Sood, Sandeep, Wang, Zhihong J.   +6 more
core   +1 more source

State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature [PDF]

, 2016
Children diagnosed with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with severe neurologic deterioration and inevitable death at a median of 9 months from diagnosis.
Cruz, O, Hargrave, DR, Kaspers, GJL, van Vuurden, DG, van Zanten, SEMV   +4 more
core   +1 more source

DIPG-52. Activators of the integrated stress response synergize to kill DIPG

Neuro-Oncology, 2022
Abstract DIPG has elevated baseline activation of the integrated stress response (ISR), an evolutionarily conserved system that allows cells to tolerate various forms of stress. Increased expression of activating transcription factor 4 (ATF4) indicates activation of the ISR.
Novak, Orlandi, Arnold, Antje, Eberhart, Charles, Raabe, Eric   +3 more
openaire   +1 more source

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting [PDF]

, 2015
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour ...
A Broniscer, A Brüning-Richardson, A M Carcaboso, A Melcher, B Wehrle-Haller, C Jones, CA Grimes, D Del Duca, DN Louis, E Ilett, G Mehta, H Eldar-Finkelman, J Johnson, J Levesley, J Luo, J V Cockle, JG Wakefield, KE Warren, L Meijer, L P Steel, M Vinci, MO Nowicki, OT Fackler, PA Agudelo-Garcia, PB Mitchell, R Hoessel, S E Lawler, S Picton, S Short, SJ Smith, SP Williams, SP Williams, T Demuth, T Siegal, T Sun, VW Van Beusechem, XH Ma   +36 more
core   +2 more sources