Results 21 to 30 of about 8,953 (160)

DIPG-14. EVALUATING THERAPEUTIC VULNERABILITIES IN DIPG TUMORS USING HIGH-THROUGHPUT SCREENING [PDF]

Neuro-Oncology, 2017
Abstract Pediatric high-grade gliomas including Diffuse Intrinsic Pontine Gliomas (DIPGs) are among the most lethal cancers known with no effective cure. Recently, somatic mutations in the H3F3A or HIST1H3B genes have been detected in the majority of midline high-grade pediatric glioma cases which leads to an amino acid change at lysine 27 of H3 to ...
Desmond Brown, David Daniels, Liang Zhang   +2 more
openaire   +1 more source

DIPG-37. Exploring the role of the epigenetic factor H2A.Z acetylation in DIPG

Neuro-Oncology, 2022
Abstract Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumor found in children with a peak incidence of 5-7 years of age, with median survival after diagnosis less than one year. In more than 60% of DIPG cases, a recurring somatic mutation in the H3F3A gene, that causes a lysine 27 to methionine substitution is ...
Sanguino, Yolanda Colino, de la Fuente, Laura Rodriguez, Kisswani, Dana, Kearney, Padraic, Jackson, Evangeline, Duchatel, Ryan, Holliday, Holly, Jabado, Nada, Tsoli, Maria, Ziegler, David, Dun, Matthew, Mora, Fatima Valdes   +11 more
openaire   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Survival rates and prognostic predictors of high grade brain stem gliomas in childhood : a systematic review and meta-analysis [PDF]

, 2017
Diagnosis of a pediatric high grade brain stem glioma is devastating with dismal outcomes. This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential prognostic factors including selected interventions ...
Hassan, Hadeel, Phillips, Robert S, Picton, Susan V, Pinches, Anne   +3 more
core   +1 more source

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease [PDF]

, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival.
Bailey, S, Barkhof, F, Baugh, J, Biassoni, V, Bison, B, Calmon, R, Cannarozzo, A, Castel, D, Chaney, B, Colditz, N, Cruz, O, Damen-Korbijn, CM, De Jongh, D, De Wolf, R, Deak, L, Emmerik, J, Entz-Werle, N, Fouladi, M, Gandola, L, Garami, M, Gerber, N, Gielen, GH, Gil-da-Costa, MJ, Giraud, G, Grill, J, Grundy, R, Hargrave, DR, Hauser, P, Hayden, T, Hoffmann, M, Holm, S, Hulleman, E, Jacobs, S, Jadrijevic-Cvrlje, F, Janssens, GO, Jones, C, Jones, DT, Kaspers, GJ, Kattamis, A, Kebudi, R, Kitanovski, L, Kivivuori, SM, Kramm, CM, Leblond, P, Lieverst, JA, Lopez-Aguilar, E, Massimino, M, members of the SIOPE DIPG Network, ., Morales La Madrid, A, Noltes, J, Nysom, K, Pears, J, Pentikainen, V, Perek-Polnik, M, Rutkauskiene, G, Sanchez Aliaga, E, Shats, L, Slavc, I, Sturm, D, Sumerauer, D, Thorarinsdottir, HK, Torsvik, IK, Van Dijk, J, Van Gool, S, van Vuurden, DG, Vandertop, WP, Varlet, P, Veldhuijzen van Zanten, SE, von Bueren, AO, Warmuth-Metz, M, Zapata-Tarres, M, Zheludkova, O   +71 more
core   +5 more sources

Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours [PDF]

, 2016
The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading ...
Beccaria, Kévin, Brem, Henry, Carcaboso, Angel M., Clifford, Steven C., Fleischhack, Gudrun, Gilbertson, Richard J., Gill, Steven, Green, Jordan J., Greenwood, John, Ivanov, Delyan P., Jacques, Thomas S., Kearns, Pamela R., Kilday, John-Paul, Lowis, Stephen, Macarthur, Donald, Meijer, Lisethe, Morrissy, A. Sorana, Nailor, Audrey, Pearl, Monica S., Penny, Jeffrey I., Pilkington, Geoffrey J., Rahman, Ruman, Slavc, Irene, Smith, Stuart, Straathof, Karin, van Vuurden, Dannis G., Walker, David A., Warren, Kathy E.   +27 more
core   +3 more sources

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]

, 2017
Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M, Lowis, Stephen P, Malik, Karim, Singleton, Will G B, Williams, Maria J   +4 more
core   +1 more source

Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]

, 2014
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core   +1 more source

Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Fillmore, Helen, Loveson, Katie
core   +1 more source