Results 41 to 50 of about 8,953 (160)

Origin, criterion, and mechanism of vortex-core reversals in soft magnetic nanodisks under perpendicular bias fields [PDF]

, 2014
We studied dynamics of vortex-core reversals driven by circular rotating fields along with static perpendicular magnetic fields of different direction and strength.
Jeong, Dae-Eun, Kim, Sang-Koog, Lee, Ki-Suk, Yoo, Myoung-Woo   +3 more
core   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

A Phase 1 Trial of Fimepinostat in Children and Adolescents With Relapsed and Refractory Solid and CNS Tumors

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Fimepinostat, an oral dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K), has shown activity in preclinical models of Myc‐driven pediatric malignancies. This Phase 1 trial aimed to determine the recommended pediatric Phase 2 dose (RPP2D), describe the toxicity profile, and evaluate
David S. Shulman, Kieuhoa T. Vo, Frank M. Balis, Holly Lindsay, Rochelle Bagatell, Andrew E. Place, Susan N. Chi, Suzanne Shusterman, Suzanne Ezrre, Jeffrey Czaplinski, Ketki Bhushan, Pei‐Chi Kao, Wendy B. London, Steven G. DuBois   +13 more
wiley   +1 more source

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age [PDF]

, 2015
Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients.
Amon, Baker, Barnholtz-Sloan, Barnholtz-Sloan, Chun, Chun, Chun, Cleveland, Collins, Collins, Collins, Compton, Cotman, Coyle, Cui, Di Agostino, Eischen, Eischen, Fletcher, Gandolfi, Gray, Gronych, Grundy, Guadagno, Guadagno, Gutmann, Gutmann, Hasselblatt, Hawkins, Hoffmann, Hoffmann, Hoffmann, Hoffmann, Huether, Jones, Kleihues, Kruchko, Lee, Levine, Li, Liu, Lozano, Lozano, Manfredi, Montagna, Montagna, Paulus, Pekrun, Pellman, Pfister, Prados, Puduvalli, Reifenberger, Rhee, Van den Berghe, Zlotnik   +55 more
core   +5 more sources

Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry

Neuro-Oncology, 2021
Abstract Background Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.
Margot A Lazow, Christine Fuller, Mariko DeWire, Adam Lane, Pratiti Bandopadhayay, Ute Bartels, Eric Bouffet, Sylvia Cheng, Kenneth J Cohen, Tabitha M Cooney, Scott L Coven, Hetal Dholaria, Blanca Diez, Kathleen Dorris, Moatasem El-ayadi, Ayman El-Sheikh, Paul G Fisher, Adriana Fonseca, Mercedes Garcia Lombardi, Robert J Greiner, Stewart Goldman, Nicholas Gottardo, Sridharan Gururangan, Jordan R Hansford, Tim Hassall, Cynthia Hawkins, Lindsay Kilburn, Carl Koschmann, Sarah E Leary, Jie Ma, Jane E Minturn, Michelle Monje-Deisseroth, Roger Packer, Yvan Samson, Eric S Sandler, Gustavo Sevlever, Christopher L Tinkle, Karen Tsui, Lars M Wagner, Mohamed Zaghloul, David S Ziegler, Brooklyn Chaney, Katie Black, Anthony Asher, Rachid Drissi, Maryam Fouladi, Blaise V Jones, James L Leach   +47 more
openaire   +2 more sources

Revisiting the Incidence of Hypercalcemia in Contemporary Diagnoses of Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT Background Hypercalcemia is rarely observed in pediatric patients with cancer. However, rare cases of renal insufficiency and osteoporosis have been reported as severe consequences. Published literature focuses predominantly on hypercalcemia in pediatric hematologic malignancies, precluding causative associations with solid tumor disease ...
Felicia Y. Ho, Dajana Alku, Chalinee Monsereenusorn, Nan Chen, Wendy B. London, Allison F. O'Neill   +5 more
wiley   +1 more source

DIPG-49. SPATIAL TRANSCRIPTOMIC SEQUENCING OF A DIPG PATIENT TUMOUR RESOURCE

Neuro-Oncology
Abstract BACKGROUND Diffuse Intrinsic Pontine Glioma (DIPG), the most common subtype of Diffuse Midline Glioma (DMG), is a brainstem high-grade glioma arising in young children and always proves fatal.
Kordowski, Anja, Mulay, Onkar, Harris, Lachlan, Nguyen, Quan H, Day, Bryan W   +4 more
openaire   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, Volume 116, Issue 12, Page 3250-3265, December 2025.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics [PDF]

, 2013
Background Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in adult
Chenevert, D. P. Auer, D. Rodriguez Gutierrez, Ellingson, Ellingson, Ellingson, Harris, Kumar, Lee, M. Manita, Macdonald, Moffat, Prabhu, R. A. Dineen, R. G. Grundy, Schubert, T. Jaspan, Therasse, Wahl   +18 more
core   +1 more source

DIPG-72. CREATION, CHARACTERIZATION AND CATALOGUING NEXT-GENERATION DIPG PATIENT-DERIVED CANCER CELL LINES: THE DIPG C3 PROJECT

Neuro-Oncology
Abstract BACKGROUND Preclinical studies of diffuse intrinsic pontine glioma (DIPG) have increased significantly over the past 15 years due to the development of DIPG disease-specific tools including cell lines and animal models. We now know that DIPG is a molecularly heterogeneous tumor. While >
Bhatia, Sonam, Quinn, Thomas, Chow, Kin-Hoe, Vogelzang, Jayne, Shetty, Aniket, Yerrum, Smitha, Monje, Michelle, Raabe, Eric, Filbin, Mariella, Hulleman, Esther, Ligon, Keith L, Warren, Katherine   +11 more
openaire   +1 more source