Results 51 to 60 of about 8,953 (160)

DIPG-27. DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) CHALLENGE: FROM GENE EXPRESSION PROFILE TO DRUG

Neuro-Oncology, 2023
Abstract Diffuse intrinsic pontine glioma (DIPG) accounts for 80% of pediatric brainstem tumors and about 10-20% of all central nervous system tumors in childhood. Despite the adoption of aggressive therapeutic approaches, DIPG remains the leading cause of cancer-related mortality in childhood: prognosis is still poor with more than 90 ...
Scilimati, Antonio, Armenise, Domenico, Baldelli, Olga, Centonze, Antonella, Derri, Davide, Ferorelli, Savina, Miciaccia, Morena, Solidoro, Roberta, Perrone, Maria Grazia   +8 more
openaire   +1 more source

Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
Radioresistant H3K27M‐pediatric diffuse midline glioma‐derived extracellular vesicles enhance DNA repair and trigger metabolic and transcriptional changes in radiosensitive tumor cells. These findings reveal vesicle‐mediated intratumoral communication as a driver of intrinsic radioresistance and suggest novel targets to disrupt therapy‐resistant ...
Viral D. Oza, Kenan A. Flores, Yelena Chernyavskaya, Majd A. Al‐Hamaly, Caitlyn B. Smith, Ronald C. Bruntz, Jessica S. Blackburn   +6 more
wiley   +1 more source

Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy

Medicinal Research Reviews, Volume 45, Issue 6, Page 1651-1661, November 2025.
ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati   +9 more
wiley   +1 more source

DIPG-71. XPEDITE: A STUDY TO EXPEDITE DIPG AND DMG RESEARCH

Neuro-Oncology
Abstract BACKGROUND Diffuse midline glioma (DMG), particularly the subtype known as diffuse intrinsic pontine glioma (DIPG), poses a significant challenge due to its aggressive nature and low survival rates, especially in children.
Stuhlmiller, Timothy J, Ward, Lisa, Lewis, Sarah, Cole, Zachariah D, Chuyka, Donald, Ginn, Sarah, Federowicz, Bryan, Shapiro, Mark A   +7 more
openaire   +1 more source

Three and Four Courses of Radiation for Children With Recurrent Diffuse Intrinsic Pontine Glioma

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Purpose Re‐irradiation (RT2) for children with diffuse intrinsic pontine glioma (DIPG) is increasingly used upon recurrence; however, limited data are available for evaluating additional courses of radiotherapy (RT) for DIPG. The purpose of this case series was to report our institutional experience in treating patients with recurrent DIPG ...
Nisha Shariff, Anthony Lausch, Eric Bouffet, Derek S. Tsang   +3 more
wiley   +1 more source

ODC‐Driven Polyamines Synthesis Sustains the Self‐Renewal of Glioblastoma Stem Cells and Drives Tumor Aggressiveness

Cancer Science, Volume 116, Issue 11, Page 3079-3089, November 2025.
Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Xue‐Chen Wei, Hao‐Qian Zhang, Guang‐Qin Liu, Chang‐Wei Liu, Ai‐ling Li, Xin Pan, Wei‐Qun Yan, Jia‐Yi Chen   +7 more
wiley   +1 more source

DIPG-20. DETERMINATION AND MANAGEMENT OF HYDROCEPHALUS IN PATIENTS WITH DIPG, AN INSTITUTIONAL EXPERIENCE

Neuro-Oncology, 2020
Abstract BACKGROUND The is no consensus in best practices for the management of hydrocephalus in patients with Diffuse Intrinsic Pontine Glioma (DIPG). To date, the impact on survival of hydrocephalus and Cerebro-Spinal Fluid (CSF) diversion in this population remains to be elucidated.
Fonseca, Adriana, Solano-Paez, Palma, Zapotocky, Michal, Bartels, Ute, Bouffet, Eric   +4 more
openaire   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

DIPG-67. RE-IRRADIATION PRACTICES AND OUTCOMES IN PATIENTS WITH DIPG/DMG: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY

Neuro-Oncology
Abstract BACKGROUND Given that radiation therapy is the only treatment modality demonstrated to result in any clinical benefit for children with DIPG, re-irradiation therapy has been explored as a treatment option for progressive DIPG.
Pillay-Smiley, N, Webster, A, Lane, A, Hawkins, C, Hassall, T, Leach, J, Jones, B, Dorris, K, Hansford, JR, Zaghloul, M, Cheng, S, Hummel, TR, Hoffman, LM, Warren, KE   +13 more
openaire   +2 more sources

Immune Surveillance and Immune Escape in Cancer: Mechanisms and Immunotherapy

MedComm, Volume 6, Issue 10, October 2025.
Our review focused on how specific cellular subsets crucial for igniting tumor immunity cycle, notably effector and helper T cells alongside antigen presentation cells, interact closely in both antigen‐dependent and ‐independent manners (within centered ring) adjacent to cancer cells.
Ying Peng, Linsheng Zhan, Jianxiang Shi, Jie Wang, Yueying Li, Xiangdong Sun, Jie Lv, Huiyu Yang, Zan Qiu, Xingzhao Liu, Chenyan Li, Shanshan Gong, Wen Jia, Huiying Wang, Yuqi Zhao, Bin Zhang, Wei Guo, Jiancheng Guo, Jian Shang, Qianqian Zhou, Yanan Yang, Feng Gao   +21 more
wiley   +1 more source