Results 61 to 70 of about 8,953 (160)

Opportunities and challenges for successful use of bevacizumab in pediatrics [PDF]

, 2013
Bevacizumab (Avastin) has rapidly gained status as a broadly active agent for malignancies of several different histologies in adults. This activity has spawned a range of uses in pediatrics for both oncologic and non-oncologic indications.
Barone, Amy, Rubin, Joshua B
core   +3 more sources

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, Volume 12, Issue 35, September 18, 2025.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma [PDF]

, 2014
High-grade Brainstem Glioma (BSG), also known as Diffuse Intrinsic Pontine Glioma (DIPG), is an incurable pediatric brain cancer. Increasing evidence supports the existence of regional differences in gliomagenesis such that BSG is considered a distinct ...
Baker, Suzanne J., Barton, Kelly L., Becher, Oren J., Chung, Alexander, Conway, Simon J., Corcoran, David L., Diaz, Alexander K., Misuraca, Katherine L.   +7 more
core   +3 more sources

What Epigenetics Teaches Us About Neuron–Glioma Interactions

BioEssays, Volume 47, Issue 9, September 2025.
Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty, Itzel Nissen, Silvia Remeseiro   +2 more
wiley   +1 more source

Ketogal: A Derivative Ketorolac Molecule with Minor Ulcerogenic and Renal Toxicity [PDF]

, 2017
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the ...
Antonio Calignano, Bice Avallone, Carla Cirillo, Carmen Avagliano, Carmen De Caro, Carmen De Caro, Claudia Cristiano, Gianpiero Boatto, Giovanna La Rana, Giovanni Sarnelli, Maria G. Rimoli, Maria Nieddu, Roberta Troiano, Roberto Russo, Rosario Cuomo, Salvatore Magliocca   +15 more
core   +2 more sources

Multimodal management and outcome of pediatric and adolescent malignant central nervous system tumors: A single‐center retrospective study

Malignancy Spectrum, Volume 2, Issue 3, Page 128-139, September 2025.
Abstract Objective There is a paucity of real‐world evidence in the Indian context to address the outcome of primary brain tumors (PBTs) in children. This study aimed to describe the demographic profile, clinical characteristics, and histological features of PBTs based on the 2016 World Health Organization classification, assess the efficacy of ...
Priyadharshini Veeralakshmanan, Wesley M. Jose, Suhas Udayakumaran, M. R. Bindhu, Debnarayan Dutta, Kannan Rajesh, Sruthi Kavalagunta, Renjitha Bhaskaran, Nikhil K. Haridas, M. P. Rakesh, Keechilat Pavithran   +10 more
wiley   +1 more source

Experimental combination therapy of brain cancer cell models [PDF]

, 2012
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and adults, respectively.
Marino, Ana-Maria
core   +1 more source

DIPG-74. DNA METHYLATION STOCHASTICITY IN DIPG [PDF]

Neuro-Oncology, 2018
Michael Koldobskiy, Garrett Jenkinson, Elisabet Pujadas, Allison Martin, Charles Eberhart, John Goutsias, Eric Raabe, Andrew Feinberg   +7 more
openaire   +1 more source

Optimisation of RNP electroporation in SU DIPG IV patient derived DIPG cell line

, 2019
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen,
Brown, Elizabeth, Felce, Ling, Farnie, Gillian, Bullock, Alex   +3 more
openaire   +1 more source

How many human proteoforms are there? [PDF]

, 2018
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which
Aebersold, Ruedi, Agar, Jeffrey N, Amster, I Jonathan, Baker, Mark S, Bertozzi, Carolyn R, Boja, Emily S, Costello, Catherine E, Cravatt, Benjamin F, Fenselau, Catherine, Garcia, Benjamin A, Ge, Ying, Gunawardena, Jeremy, Hendrickson, Ronald C, Hergenrother, Paul J, Huber, Christian G, Ivanov, Alexander R, Jensen, Ole N, Jewett, Michael C, Kelleher, Neil L, Kiessling, Laura L, Krogan, Nevan J, Larsen, Martin R, Loo, Joseph A, Lundberg, Emma, MacCoss, Michael J, Mallick, Parag, Mootha, Vamsi K, Mrksich, Milan, Muir, Tom W, Ogorzalek Loo, Rachel R, Patrie, Steven M, Pesavento, James J, Pitteri, Sharon J, Rodriguez, Henry, Saghatelian, Alan, Sandoval, Wendy, Schlüter, Hartmut, Sechi, Salvatore, Slavoff, Sarah A, Smith, Lloyd M, Snyder, Michael P, Thomas, Paul M, Uhlén, Mathias, Van Eyk, Jennifer E, Vidal, Marc, Walt, David R, White, Forest M, Williams, Evan R, Wohlschlager, Therese, Wysocki, Vicki H, Yates, Nathan A, Young, Nicolas L, Zhang, Bing   +52 more
core   +2 more sources