Results 301 to 310 of about 20,669 (341)

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, EarlyView.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis. [PDF]

Nucleic Acids Res
Ranjbarian F, Rafie K, Shankar K, Krakovka S, Svärd SG, Carlson LA, Hofer A.   +6 more
europepmc   +1 more source

THE SYNTHESIS OF CYTIDINE DIPHOSPHATE CHOLINE, CYTIDINE DIPHOSPHATE ETHANOLAMINE, AND RELATED COMPOUNDS

Journal of Biological Chemistry, 1956
openaire   +3 more sources

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

The FEBS Journal, EarlyView.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs. [PDF]

Nat Commun
McCown C, Yu CH, Ivanov DN.
europepmc   +1 more source

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

The FEBS Journal, EarlyView.
NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg, Ornella Bimaï, Saher Shahid, Lena Philipp, Markel Martínez‐Carranza, Ipsita Banerjee, Daniel Lundin, Pål Stenmark, Britt‐Marie Sjöberg, Derek T. Logan   +9 more
wiley   +1 more source

A switch-on luminescent europium(iii) probe for selective and time-resolved detection of adenosine diphosphate (ADP). [PDF]

Chem Sci
Bodman SE, Stachelek P, Rehman U, Plasser F, Pal R, Butler SJ.   +5 more
europepmc   +1 more source

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

The FEBS Journal, EarlyView.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

The cis-prenyltransferase protein family in Taraxacum koksaghyz. [PDF]

Plant J
Müller B, Niephaus E, Eisenreich W, Bröker JN, Twyman RM, Prüfer D, Schulze Gronover C.   +6 more
europepmc   +1 more source