Results 111 to 120 of about 2,465 (151)
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DIPHOSPHONATES AND PAINFUL FEET
Australian and New Zealand Journal of Medicine, 1983Abstract: Localised foot pain occurred in four patients with Paget's disease of bone or myositis ossificans who were treated with disodium etidronate (EHDP) in a dose of 10 to 20 mg/kg body weight/day for four to six months. There was localised tenderness and sometimes slight swelling at the painful areas.
Richard A. Evans, D. Macdonald
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Diphosphonate Therapy in Nephrocalcinosis
British Journal of Urology, 1976The inhibiting effect of diphosphonates on calcification in tissues has led to their successful use i n conditions associated with abnormal calcification, such as niyositis ossificans (Bassett et al., 1969; Cram et al., 1971; Weiss, Fisher and Phang, 1971; Russell of et al., 1972) and Paget's disease of bone (Smith, Russell and Bishop, 1971; Altman et ...
David A. McCredie +2 more
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New diphosphonate compounds for skeletal imaging: comparison with methylene diphosphonate.
Radiology, 1983Three-hour biodistribution of Tc-99m complexes of six diphosphonates was compared in rabbits with tibial lesions to determine which was best for detection of focal bone lesions. Sr-85 was used as a standard. N,N-dimethylaminomethylene diphosphonate (DMAD) was the only agent with a higher lesion/normal bone ratio than methylene diphosphonate (MDP ...
F D Thomas +5 more
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The Journal of Bone and Joint Surgery. British volume, 1973
1. The phosphonates are simple chemical compounds containing P-C-P bonds which are resistant to the action of naturally occurring phosphatases and pyrophosphatases. They inhibit the formation and dissolution of apatite crystals in vitro and prevent ectopic mineralisation and bone resorption in animals. 2.
R. Graham, G. Russell, Roger Smith
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1. The phosphonates are simple chemical compounds containing P-C-P bonds which are resistant to the action of naturally occurring phosphatases and pyrophosphatases. They inhibit the formation and dissolution of apatite crystals in vitro and prevent ectopic mineralisation and bone resorption in animals. 2.
R. Graham, G. Russell, Roger Smith
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Diphosphonates and phosphate homoeostasis in man [PDF]
Clinical Science, 1988 1. The effects of three intravenous diphosphonates (etidronate, clodronate and aminohexane diphosphonate) on phosphate homoeostasis were studied in 30 patients with Paget's disease of bone and in three patients with hypoparathyroidism. 2.
Neveen A. T. Hamdy +5 more
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Journal of Solid State Chemistry, 2012
Three Ba{sup 2+}/UO{sub 2}{sup 2+} methylenediphosphonates have been prepared from mild hydrothermal treatment of uranium trioxide, methylendiphosphonic acid (C1P2) with barium hydroxide octahydrate, barium iodate monohydrate, and small aliquots of HF at 200 Degree-Sign C. These compounds, Ba[UO{sub 2}[CH{sub 2}(PO{sub 3}){sub 2}]{center_dot}1.4H{sub 2}
Anna-Gay D. Nelson +4 more
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Three Ba{sup 2+}/UO{sub 2}{sup 2+} methylenediphosphonates have been prepared from mild hydrothermal treatment of uranium trioxide, methylendiphosphonic acid (C1P2) with barium hydroxide octahydrate, barium iodate monohydrate, and small aliquots of HF at 200 Degree-Sign C. These compounds, Ba[UO{sub 2}[CH{sub 2}(PO{sub 3}){sub 2}]{center_dot}1.4H{sub 2}
Anna-Gay D. Nelson +4 more
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Uranyl Diphosphonates with Pillared Structures
Inorganic Chemistry, 2009A series of five uranyl diphosphonates with pillared and canted pillared structures have been prepared and characterized. These compounds are constructed from UO(6) tetragonal bipyramids and UO(7) pentagonal bipyramids that are bridged by the diphosphonate anions. All of these compounds fluoresce at room temperature.
Thomas E. Albrecht-Schmitt +1 more
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Diphosphonate Treatment of Calcinosis Universalis
New England Journal of Medicine, 1971CALCINOSIS universalis is a condition characterized by progressive accumulation of amorphous calcium phosphate and crystalline hydroxyapatite in subcutaneous lesions. The etiology is not known. Numerous modes of therapy have been proposed, including increased dietary phosphate, a diet low in calcium and high in phosphorus, a ketogenic diet, infusions ...
Robert D. Ray +3 more
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Diphosphonate Treatment of Paget??s Disease
Clinical Orthopaedics and Related Research, 1976Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy ...
Harvey C. Gonick +3 more
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DIPHOSPHONATES AND PAGET'S DISEASE OF BONE
The Lancet, 1971Abstract The diphosphonate, CH 3 C(OH)(PO 3 HNa) 2 (disodium etidronate), has been given at a daily oral dose of 20 mg. per kg. body-weight to 4 patients with biochemically active Paget's disease. The increased alkaline phosphatase in plasma and the increased hydroxyproline in plasma and urine fell steadily to about half their initial value after ...
Roslin Russell +2 more
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