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Diphosphonates: History and Mechanisms of Action
Metabolic Bone Disease & Related Research, 1981The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium phosphate to its crystalline form, and inhibited crystal aggregation and dissolution.
H Fleisch
exaly +3 more sources
Diphosphonates and Inhibition of Bone Mineralisation.
Lancet, The, 1982Linda Smith, I T Boyle, I T Boyle
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Diphosphonates in the Treatment of Myositis Ossificans.
Lancet, The, 1969H Fleisch, A Donath, R Preisig
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The Journal of Bone and Joint Surgery. British volume, 1973
1. The phosphonates are simple chemical compounds containing P-C-P bonds which are resistant to the action of naturally occurring phosphatases and pyrophosphatases. They inhibit the formation and dissolution of apatite crystals in vitro and prevent ectopic mineralisation and bone resorption in animals. 2.
R. Graham, G. Russell, Roger Smith
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1. The phosphonates are simple chemical compounds containing P-C-P bonds which are resistant to the action of naturally occurring phosphatases and pyrophosphatases. They inhibit the formation and dissolution of apatite crystals in vitro and prevent ectopic mineralisation and bone resorption in animals. 2.
R. Graham, G. Russell, Roger Smith
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Heart, 2014
An elderly patient was known with generalised osteoarthritis and destruction of the right hip. Six months before, this patient was admitted to a general hospital because of oedema and ventricular tachycardia. No coronary artery disease was found on coronary angiogram and the tachycardia was successfully converted to sinus rhythm.
Noordzij, Walter +3 more
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An elderly patient was known with generalised osteoarthritis and destruction of the right hip. Six months before, this patient was admitted to a general hospital because of oedema and ventricular tachycardia. No coronary artery disease was found on coronary angiogram and the tachycardia was successfully converted to sinus rhythm.
Noordzij, Walter +3 more
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Diphosphonate Therapy in Nephrocalcinosis
British Journal of Urology, 1976The inhibiting effect of diphosphonates on calcification in tissues has led to their successful use i n conditions associated with abnormal calcification, such as niyositis ossificans (Bassett et al. , 1969; Cram et al.
D A, McCredie, H R, Powell, E, Rotenberg
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DIPHOSPHONATES AND PAINFUL FEET
Australian and New Zealand Journal of Medicine, 1983Abstract: Localised foot pain occurred in four patients with Paget's disease of bone or myositis ossificans who were treated with disodium etidronate (EHDP) in a dose of 10 to 20 mg/kg body weight/day for four to six months. There was localised tenderness and sometimes slight swelling at the painful areas.
R A, Evans, D, MacDonald
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[Treatment with diphosphonates].
La Clinica terapeutica, 1980---
ZAVAGLI, Giorgio +2 more
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Uranyl Diphosphonates with Pillared Structures
Inorganic Chemistry, 2009A series of five uranyl diphosphonates with pillared and canted pillared structures have been prepared and characterized. These compounds are constructed from UO(6) tetragonal bipyramids and UO(7) pentagonal bipyramids that are bridged by the diphosphonate anions. All of these compounds fluoresce at room temperature.
Pius O, Adelani +1 more
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