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DIPHOSPHONATES

open access: yesThe Journal of Bone and Joint Surgery. British volume, 1973
1. The phosphonates are simple chemical compounds containing P-C-P bonds which are resistant to the action of naturally occurring phosphatases and pyrophosphatases. They inhibit the formation and dissolution of apatite crystals in vitro and prevent ectopic mineralisation and bone resorption in animals. 2.
R. Graham, G. Russell, Roger Smith
openaire   +2 more sources

Diphosphonates: History and mechanisms of action

Metabolic Bone Disease & Related Research, 1981
The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium phosphate to its crystalline form, and inhibited crystal aggregation and dissolution.
exaly   +3 more sources

Cardiac diphosphonate uptake

Heart, 2014
An elderly patient was known with generalised osteoarthritis and destruction of the right hip. Six months before, this patient was admitted to a general hospital because of oedema and ventricular tachycardia. No coronary artery disease was found on coronary angiogram and the tachycardia was successfully converted to sinus rhythm.
Noordzij, Walter   +3 more
openaire   +2 more sources

Diphosphonate Therapy in Nephrocalcinosis

British Journal of Urology, 1976
The inhibiting effect of diphosphonates on calcification in tissues has led to their successful use i n conditions associated with abnormal calcification, such as niyositis ossificans (Bassett et al. , 1969; Cram et al.
D A, McCredie, H R, Powell, E, Rotenberg
openaire   +2 more sources

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