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[Treatment with diphosphonates].
La Clinica terapeutica, 1980---
ZAVAGLI, Giorgio +2 more
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Uranyl Diphosphonates with Pillared Structures
Inorganic Chemistry, 2009A series of five uranyl diphosphonates with pillared and canted pillared structures have been prepared and characterized. These compounds are constructed from UO(6) tetragonal bipyramids and UO(7) pentagonal bipyramids that are bridged by the diphosphonate anions. All of these compounds fluoresce at room temperature.
Pius O, Adelani +1 more
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Diphosphonate Treatment of Calcinosis Universalis
New England Journal of Medicine, 1971CALCINOSIS universalis is a condition characterized by progressive accumulation of amorphous calcium phosphate and crystalline hydroxyapatite in subcutaneous lesions. The etiology is not known. Numerous modes of therapy have been proposed, including increased dietary phosphate, a diet low in calcium and high in phosphorus, a ketogenic diet, infusions ...
R L, Cram +3 more
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Diphosphates and diphosphonates in polyoxometalate chemistry
Chemical Society Reviews, 2012In the wide area of polyoxometalate (POM) chemistry, diphosphate/diphosphonate-based POMs represent a more recent area of study. However, in this short time it has emerged to become very dynamic, as shown by the wide variety of compounds reported. Ever since the discovery of the first polyoxotungstate framework constructed from diphosph(on)ate ligands,
Abhishek, Banerjee +3 more
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Diphosphonate Treatment of Paget's Disease
Clinical Orthopaedics and Related Research, 1976Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy ...
G A, Finerman +3 more
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DIPHOSPHONATES AND PAGET'S DISEASE OF BONE
The Lancet, 1971Abstract The diphosphonate, CH 3 C(OH)(PO 3 HNa) 2 (disodium etidronate), has been given at a daily oral dose of 20 mg. per kg. body-weight to 4 patients with biochemically active Paget's disease. The increased alkaline phosphatase in plasma and the increased hydroxyproline in plasma and urine fell steadily to about half their initial value after ...
R, Smith, R G, Russell, M, Bishop
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The Orthopaedic Implications of Diphosphonate Therapy
American Academy of Orthopaedic Surgeon, 2010Diphosphonates are among the many commonly prescribed drugs for osteoporosis management. These synthetic analogues of physiologically occurring inorganic pyrophosphate bind to the hydroxyapatite crystals of bone. Diphosphonates act by decreasing the amount of osteoclast-mediated bone resorption by inducing apoptosis and disrupting the mevalonate ...
Michael J, Weaver +2 more
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99MTc-diphosphonate uptake in neuroblastoma
American Journal of Roentgenology, 1976Marked uptake of 99mTc-diphosphonate was noted in an extraadrenal neuroblastoma. Calcification was not demonstrable on radiographic or light microscopic examination, nor was crystalline material identified on electron microscopic examination; capillaries in the lesion appeared to be intact.
W, McCartney +4 more
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Diphosphonates and phosphate homoeostasis in man
Clinical Science, 19881. The effects of three intravenous diphosphonates (etidronate, clodronate and aminohexane diphosphonate) on phosphate homoeostasis were studied in 30 patients with Paget's disease of bone and in three patients with hypoparathyroidism. 2.
E V, McCloskey +5 more
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New diphosphonate compounds for skeletal imaging: comparison with methylene diphosphonate.
Radiology, 1983Three-hour biodistribution of Tc-99m complexes of six diphosphonates was compared in rabbits with tibial lesions to determine which was best for detection of focal bone lesions. Sr-85 was used as a standard. N,N-dimethylaminomethylene diphosphonate (DMAD) was the only agent with a higher lesion/normal bone ratio than methylene diphosphonate (MDP ...
G, Subramanian +5 more
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