Results 181 to 190 of about 5,826 (213)

Diphosphonate Treatment of Paget??s Disease

Clinical Orthopaedics and Related Research, 1976
Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy ...
Harvey C. Gonick, Gerald A. M. Finerman, Roderick K. Smith, Jean M. Mayfield   +3 more
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DIPHOSPHONATES AND PAGET'S DISEASE OF BONE

The Lancet, 1971
Abstract The diphosphonate, CH 3 C(OH)(PO 3 HNa) 2 (disodium etidronate), has been given at a daily oral dose of 20 mg. per kg. body-weight to 4 patients with biochemically active Paget's disease. The increased alkaline phosphatase in plasma and the increased hydroxyproline in plasma and urine fell steadily to about half their initial value after ...
Roslin Russell, Roger Smith, Margaret Bishop   +2 more
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99MTc-diphosphonate uptake in neuroblastoma

American Journal of Roentgenology, 1976
Marked uptake of 99mTc-diphosphonate was noted in an extraadrenal neuroblastoma. Calcification was not demonstrable on radiographic or light microscopic examination, nor was crystalline material identified on electron microscopic examination; capillaries in the lesion appeared to be intact.
Martin L. Nusynowitz, BE Reimann, B Mazat, William H. McCartney, J Prather   +4 more
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[Treatment with diphosphonates].

La Clinica terapeutica, 1980
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ZAVAGLI, Giorgio, RICCI, Giorgio, Lo Ponte A.   +2 more
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The Orthopaedic Implications of Diphosphonate Therapy

American Academy of Orthopaedic Surgeon, 2010
Diphosphonates are among the many commonly prescribed drugs for osteoporosis management. These synthetic analogues of physiologically occurring inorganic pyrophosphate bind to the hydroxyapatite crystals of bone. Diphosphonates act by decreasing the amount of osteoclast-mediated bone resorption by inducing apoptosis and disrupting the mevalonate ...
Mark S. Vrahas, Michael J. Weaver, Micah A. Miller   +2 more
openaire   +3 more sources

Diphosphates and diphosphonates in polyoxometalate chemistry

Chemical Society Reviews, 2012
In the wide area of polyoxometalate (POM) chemistry, diphosphate/diphosphonate-based POMs represent a more recent area of study. However, in this short time it has emerged to become very dynamic, as shown by the wide variety of compounds reported. Ever since the discovery of the first polyoxotungstate framework constructed from diphosph(on)ate ligands,
Gerd-Volker Röschenthaler, Bassem S. Bassil, Abhishek Banerjee, Ulrich Kortz   +3 more
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Diphosphonate und Harnsteinbildung [PDF]

, 1974
Die Harnsteine bestehen zum grosten Teil aus kristallinem Material, wie Calciumoxalat, Calciumphosphat, Magnesiumammoniumphosphat, Urat oder Harnsaure, worunter die Calciumsalze den wichtigsten Platz einnehmen. Somit ist in der Pathophysiologie der Harnsteinbildung die Ausfallung dieser Substanzen von wesentlicher Bedeutung.
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Metabolic Effects of Diphosphonate in Primary Hyperparathyroidism

The Journal of Clinical Pharmacology, 1977
Six patients with primary hyperparathyroidism (PHPT) and one with squamous cell carcinoma of the esophagus with parathyroid hormone excess received disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) at a daily dose of 20 mg/kg orally. During treatment, the decrease in urinary calcium, total urinary hydroxyproline, and fasting urinary calcium suggested ...
Mark Haussler, Mark Haussler, Mark Haussler, Charles Y.C. Pak, Charles Y.C. Pak, Charles Y.C. Pak, Gerald W. Dietz, Gerald W. Dietz, Gerald W. Dietz, Carol Poindexter, Carol Poindexter, Carol Poindexter, W. Blair Geho, W. Blair Geho, W. Blair Geho, Roy A. Kaplan, Roy A. Kaplan, Roy A. Kaplan   +17 more
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Benign myocardial uptake of hydroxymethylene diphosphonate

Nuclear Medicine Communications, 1994
During 'routine' bone scanning with diphosphonates, 10 elderly men were noted to show prominent myocardial uptake of Tc-hydroxymethylene diphosphonate (HDP) consistently, but no heart activity was seen with Tc-methylene disphosphonate (MDP). None had evidence of recent myocardial injury and the uptake persisted over a period of many months.
Jones A, Keeling D
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Skeletal uptake of diphosphonate: A review

European Journal of Nuclear Medicine, 1980
The diphosphonates are currently the skeletal imaging agents of choice and while extremely sensitive for bony abnormality their mechanism of action remains poorly understood. The current concepts in bone uptake mechanisms are reviewed and it is concluded that diphosphonate uptake is most likely related to sites of newly forming bone with diphosphonate ...
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