Results 61 to 70 of about 5,826 (213)
Prediction of Cardiac ATTR Depletion by NI006 (ALXN2220) Using Mechanistic PK/PD Modeling
Clinical Pharmacology &Therapeutics, Volume 117, Issue 1, Page 261-269, January 2025.NI006 (aka ALXN2220) is a therapeutic antibody candidate in phase III clinical development for the depletion of amyloid transthyretin (ATTR) in patients with ATTR cardiomyopathy, an infiltrative cardiomyopathy leading to increased left ventricular wall thickness (LVWT).
Aubin Michalon +10 more
wiley +1 more source
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2023 Objective: To determine the level of scientific information of dental surgeons who carry out their professional activities in Brazil about antiresorptive drugs and indicated pharmacological procedures aiming at the prevention of osteonecrosis of the jaws
Flávia Godinho Costa Wanderley Rocha +1 more
doaj
Functional Screen of Wilson Disease ATP7B Variants Reveals Residual Transport Activities
Human Mutation, Volume 2025, Issue 1, 2025.Wilson disease is a disorder of copper (Cu) homeostasis caused by the malfunction of Cu transporter ATP7B and associated Cu accumulation in tissues. The existence of over 700 disease‐associated variants in the ATP7B gene and a broad spectrum of disease manifestations complicate the analysis of genotype–phenotype correlations and the development of ...
Jenifer S. Calvo +7 more
wiley +1 more source
A Two‐Stage CNN‐Based Method for Enhanced Metastasis Segmentation in SPECT Bone Scans
International Journal of Intelligent Systems, Volume 2025, Issue 1, 2025.Accurate segmentation of metastatic lesions is crucial for improving the quality of patient care, particularly in the context of bone scans. However, existing automated methods, which are predominantly data‐driven, exhibit limited performance and lack interpretability.
Yang He +6 more
wiley +1 more source
Amiloidosi da transtiretina (ATTR): l’altra faccia della medaglia
Giornale di Clinica Nefrologia e Dialisi, 2019 Transthyretin amyloidosis (ATTR) is becoming an emerging clinical entity, and is currently the most common form of systemic amyloidosis. ATTR consists of two distinct diseases depending on whether the amyloid fibrils derive from the intact molecule of ...
Federico Perfetto +7 more
doaj +1 more source
Physicians' perspectives on the treatment of osteoporosis patients with bisphosphonates
Clinical Interventions in Aging, 2016 Tao Gu,1 Debra F Eisenberg Lawrence,1 Judith J Stephenson,1 Jingbo Yu2 1HealthCore, Wilmington, DE, 2Merck & Co., Inc., Kenilworth, NJ, USA Background: Noncompliance with bisphosphonate therapy among osteoporosis patients attenuates the reduction ...
Gu T +3 more
doaj
TREATMENT OF MYOSITIS OSSIFICANS PROGRESSIVA WITH A DIPHOSPHONATE
The Lancet, 1972 Abstract The diphosphonate, disodium etidronate (ethane-1-hydroxy-1,1-diphosphonate, 'EHDP'), a compound known to inhibit the crystal growth of hydroxyapatite and to prevent ectopic calcification in experimental animals, has been given to two women with myositis ossificans progressiva.
Roslin Russell +4 more
openaire +4 more sources
Solvent Extraction of Inorganic Nitrates with Diphosphonate Ester. I. Zirconium, Yttrium and Lanthanide Nitrates [PDF]
, 1961 Hideo Saisho
openalex +1 more source
THE USE OF DIPHOSPHONATES IN MYELOMA [PDF]
British Journal of Haematology, 1983 A.D. Paterson +2 more
openaire +3 more sources
Response of a co-culture model of epithelial cells and gingival fibroblasts to zoledronic acid
Brazilian Oral ResearchOsteonecrosis of the jaw is an adverse effect of bisphosphonates. While the etiopathogenesis of this condition has been investigated, the interactions and effects of bisphosphonates on oral mucosa cells remain unclear.
Fernanda Gonçalves BASSO +6 more
doaj +1 more source