Results 41 to 50 of about 3,779 (178)

Diagnosis and management of osteoporosis in the older senior

Clinical Interventions in Aging, 2009
Sheryl F Vondracek, Sunny A LinneburDepartment of Clinical Pharmacy, School of Pharmacy C238-L15, University of Colorado Denver, Aurora, CO, USAAbstract: The older senior is at high risk for osteoporosis.
Sheryl F Vondracek, Sunny A Linnebur
doaj  

Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT—A Prospective Comparative Study

Diagnostics
Objectives: The purpose of this study was to investigate the imaging characteristics of medication-related osteonecrosis of the jaw (MRONJ) using [18F]fluoride positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose (FDG ...
Christian Philipp Reinert, Christina Pfannenberg, Brigitte Gückel, Helmut Dittmann, Christian la Fougère, Konstantin Nikolaou, Siegmar Reinert, Rouven Schönhof, Sebastian Hoefert   +8 more
doaj   +1 more source

Bilateral Knee Osteonecrosis in an Adolescent With Leukemia on Prolonged Corticosteroids: Discordant Femoral–Tibial Findings on Bone Scan SPECT–CT

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Osteonecrosis (avascular necrosis, AVN) is a disabling complication of corticosteroid exposure and is well recognized in adolescents treated for hematologic malignancies, including acute lymphoblastic leukemia (ALL). We report a 17‐year‐old female with ALL and later acute myelogenous leukemia (AML) after hematopoietic stem cell transplantation
Fatemeh Haghighi, Fatemeh Tahghighi Sharabian, Fatemeh Jooshaei, Farzaneh Ghaffari Yousefzadeh, Marzieh Ebrahimi, Zeinab Paymani   +5 more
wiley   +1 more source

Studying Phosphoroorganic Modification of Smac‐Mimetics to Boost Selectivity for cIAP1‐BIR3 and Unravel cIAP1/XIAP Molecular Inhibition Mechanisms

Asian Journal of Organic Chemistry, Volume 15, Issue 7, July 2026.
The phosphoroorganic modification of Smac‐mimetics (SMs) drives selectivity for cIAP1‐ over XIAP‐BIR3. The divalent SM 6 partially dimerizes cIAP1, whereas it prefers intramolecular binding in XIAP. In XIAP the phosphoroorganic moiety of the monovalent SM 7 functions as an IBM, thus inhibiting both BIR2 and BIR3. Created in BioRender.
Elisa Fagnani, Paolo Cocomazzi, Waldemar Goldeman, Marcin Sieńczyk, Francesco Bonì, Mona Amini Baghbadorani, Agnieszka Łupicka‐Słowik, Federica Cossu   +7 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Prophylactic zoledronic acid therapy to prevent or modify Paget’s disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Efficacy and Mechanism Evaluation
Background Paget’s disease of bone is characterised by focal abnormalities of bone turnover resulting in various complications. It often presents at an advanced stage with irreversible bone damage. At this point, the symptomatic benefits of treatment are
Jonathan Phillips, Deepak Subedi, Steff C Lewis, Catriona Keerie, Stuart H Ralston   +4 more
doaj   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, Volume 4, Issue 3, Page 206-218, June 2026.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

Low dose radiation 18F–fluoride PET/CT in the assessment of Unilateral Condylar Hyperplasia of the mandible: preliminary results of a single centre experience

European Journal of Hybrid Imaging, 2018
Background Unilateral condylar hyperplasia (UCH) of the mandible, or Hypercondylia, is a pathological condition that determines an abnormal growth of the affected condyle. Bone SPECT with Tc99m-diphosphonates is a successful tool in the diagnosis of UCH.
G. M. Lima, S. Diodato, E. Costabile, G. Cicoria, S. Civollani, C. Marchetti, P. L. Guidalotti, C. Pettinato, C. Nanni, S. Fanti   +9 more
doaj   +1 more source

Diphosphonates in the treatment of osteoporosis

Cleveland Clinic Journal of Medicine, 1990
Etidronate disodium has been shown to increase bone density and decrease fracture rates, but it may have more important applications in the prevention of bone loss.
openaire   +2 more sources

Real‐World Diagnostic Workup of Patients Suspected for Light Chain Amyloidosis and Wild‐Type Transthyretin Amyloid Cardiomyopathy: A Retrospective Cohort Study Using US Electronic Health Records

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Light chain (AL) amyloidosis and transthyretin amyloid cardiomyopathy (ATTR‐CM) are the most common types of cardiac amyloidosis. Despite similar manifestations, prognosis and treatments are distinct, emphasizing the importance of accurate and timely diagnosis. This retrospective cohort study assessed real‐world diagnostic workups
Muhamed Baljevic, Haechung Chung, Jose Alvir, Patrick Feron, Aaron Crowley, Darrin Benjumea, Yong Chen, Cindi Pankratova   +7 more
wiley   +1 more source