Results 71 to 80 of about 7,598 (253)
ChemMedChem, Volume 20, Issue 19, October 6, 2025.Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych +11 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2017 Background Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden.
Ji-Heh Park +6 more
doaj +1 more source
Integral membrane pyrophosphatases : A novel drug target for human pathogens? [PDF]
, 2016 Membrane-integral pyrophosphatases (mPPases) are found in several human pathogens, including Plasmodium species, the protozoan parasites that cause malaria.
Adrian Goldman +4 more
core +3 more sources
Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase
Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik +4 more
wiley +1 more source
Use of Bone Scanning and Skeletal Radiography in the Diagnosis of Bone Metastasis [PDF]
, 1975 The radionuclide bone scan is becoming increasingly useful for evaluating a wide variety of bone and joint disorders. However, the commonest application is still the detection of skeletal metastases in the patient with known or suspected neoplastic ...
Hoffer, Paul B., Mall, Jay C.
core +1 more source
Phantom Validation of Tc-99m Absolute Quantification in a SPECT/CT Commercial Device. [PDF]
, 2016 Aim. Similar to PET, absolute quantitative imaging is becoming available in commercial SPECT/CT devices. This study's goal was to assess quantitative accuracy of activity recovery as a function of image reconstruction parameters and count statistics in a
Gnesin, S. +5 more
core +3 more sources
Clinical Oral Implants Research, Volume 36, Issue 10, Page 1173-1201, October 2025.ABSTRACT Objectives Patients receiving antiresorptive medication (AR) for osteoporosis or cancer are at risk of medication‐related osteonecrosis of the jaws (MRONJ), especially after surgical procedures. Dental implant (DI) placement in high‐dose AR (HDAR) patients is widely discouraged, and thorough counseling is recommended for low‐dose AR (LDAR ...
Sanne Werner Moeller Andersen +4 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2020 Background Transient osteoporosis of the hip (TOH) is a rare and temporary clinical condition characterised by bone marrow edema (BME), severe pain, and functional limitation.
Marco Paoletta +5 more
doaj +1 more source
Prevention of bone mineral changes induced by bed rest: Modification by static compression simulating weight bearing, combined supplementation of oral calcium and phosphate, calcitonin injections, oscillating compression, the oral diophosphonatedisodium etidronate, and lower body negative pressure [PDF]
The phenomenon of calcium loss during bed rest was found to be analogous to the loss of bone material which occurs in the hypogravic environment of space flight. Ways of preventing this occurrence are investigated.
Donaldson, C. L. +9 more
core +1 more source
Targeted microbubbles: a novel application for the treatment of kidney stones [PDF]
, 2015 Kidney stone disease is endemic. Extracorporeal shockwave lithotripsy was the first major technological breakthrough where focused shockwaves were used to fragment stones in the kidney or ureter. The shockwaves induced the formation of cavitation bubbles,
Bailey, Michael +8 more
core +1 more source