Results 121 to 130 of about 542,716 (249)

Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical ...
Mohaddeseh Parvand, Fahimeh Nemati Mansour, Jafar Amani   +2 more
doaj  

Diphtheria

Diphtheria is a respiratory disease caused by bacteria.Publication date from document ...

core   +1 more source

Characterization and cytotoxicity properties of a diphtheria toxin-neurotrophin-4-fusion protein fused to diphtheria toxin

, 1997
A diphtheria toxin-neurotrophin-4/5 (NT-4/5) chimera (DAB389-NT4), in which the native receptor binding domain of diphtheria toxin was replaced with a synthetic gene encoding rat NT-4/5, was expressed, refolded, and purified.
NEGRO, ALESSANDRO, AND SKAPER S. D.
core  

Engineering Diphtheria Toxin as an Intracellular Protein Delivery Platform

, 2019
Despite enormous efforts, delivery of protein-based therapeutics into the cytosol of target cells remains one of the greatest challenges facing biotechnology.
Park, Minyoung
core   +1 more source

Severe faucial diphtheria with myocarditis: a case report

Zdorovʹe Rebenka
Background. Diphtheria is a potentially fatal contagious disease caused by toxigenic strains, characterized by inflammation of the upper respiratory tract mucosa, and may further generate toxicity in the myocardium and peripheral nerve.
Gabriella Tandipayuk, Seruni Estari, Dominicus Husada, Leny Kartina, Dwiyanti Puspitasari   +4 more
doaj   +1 more source

HISTIDINE-21 IS INVOLVED IN DIPHTHERIA-TOXIN NAD+ BINDING

, 1990
Histidine-21 is the sole histidine present in the A chain of diphtheria toxin and recent evidence suggests that it is involved in NAD+ binding. Fluorimetric assays of NAD+ binding and diethylpyrocarbonate modification performed at different pH values ...
MONTECUCCO C., RAPPUOLI R, PAPINI, EMANUELE, SCHIAVO G   +3 more
core  

Optimization of diphtheria toxin production by Corynebacterium diphtheriae using a casein-based medium in a fermenter

, 2016
The Td-based combined vaccine contains only small amounts of the diphtheria toxoid antigen. However, a high level of purity is necessary for this antigen.
T Y Kim, Sang-Mi Lee, S M Lee, Yong Kyung Choe, I H Kim, Yong-Ju Chung, Jin-A Lee, Mi-Young Jung, Y J Chung, Tae-Yeon Kim, Ik-Hwan Kim, M Y Jung, Yong-Kyung Choe, J A Lee   +13 more
core   +1 more source

Properties of the left ventricular myocardium structure in experimental acute diphtheria intoxication

RUDN Journal of Medicine, 2014
Diphtheria is considered to be vaccine-preventable disease due to organized immunization programmes. However there are still endemic regions of diphtheria, whence reports of mortal cases are coming.
A Ju Korshunova, M L Blagonravov, V A Frolov, M M Azova   +3 more
doaj  

Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain. [PDF]

Toxins (Basel), 2023
Rodnin MV, Vasques-Montes V, Kyrychenko A, Oliveira NFB, Kashipathy MM, Battaile KP, Douglas J, Lovell S, Machuqueiro M, Ladokhin AS.   +9 more
europepmc   +1 more source

DtxR is a global iron-dependent regulatory protein with multiple roles in the control of gene expression in Corynebacterium diphtheriae

Journal of Bacteriology
Corynebacterium diphtheriae is the causative agent of diphtheria, a severe respiratory disease in humans. Diphtheria toxin, encoded by the tox gene, is a potent exotoxin secreted by C.
Lindsey R. Lyman, Eric D. Peng, Michael P. Schmitt   +2 more
doaj   +1 more source