Results 101 to 110 of about 215,613 (217)

Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model

, 2017
Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon equine diphtheria anti-toxin (DAT), with a 10% risk of serum sickness and rarely anaphylaxis.
Leney, Mark, Barton, Bruce A, Smith, Heidi L., Molrine, Deborah C., Cheslock, Peter S.   +4 more
core   +1 more source

DtxR is a global iron-dependent regulatory protein with multiple roles in the control of gene expression in Corynebacterium diphtheriae

Journal of Bacteriology
Corynebacterium diphtheriae is the causative agent of diphtheria, a severe respiratory disease in humans. Diphtheria toxin, encoded by the tox gene, is a potent exotoxin secreted by C.
Lindsey R. Lyman, Eric D. Peng, Michael P. Schmitt   +2 more
doaj   +1 more source

Evaluation of human antibody responses to diphtheria toxin subunits A and B in various age groups

, 2007
This study aimed to evaluate human antibody responses to diphtheria toxin subunits in various age groups. Antibodies against the intact diphtheria toxin and the diphtheria toxin subunits A and B were evaluated in 1319 individuals using a double-antigen ...
Aybay, C., Caglar, K., Karakus, RESUL
core   +1 more source

The Diphtheria Disease [PDF]

This study, ‘The Diphtheria Disease’ explored the historical significance, etiology, symptoms, transmission, and preventive measures related to diphtheria. The study adopted a qualitative meta-analysis approach.
Muekara Friday Dugbor
core   +1 more source

Determination of Diphtheria Toxin in Bacterial Cultures by Enzyme Immunoassay. [PDF]

Diagnostics (Basel), 2022
Simonova MA, Melnikov VG, Lakhtina OE, Komaleva RL, Berger A, Sing A, Zavriev SK.   +6 more
europepmc   +1 more source

Evaluation of antidiphtheria toxin nanobodies

Nanotechnology, Science and Applications, 2010
Ghada H ShakerDepartment of Microbiology and Immunology, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi ArabiaAbstract: Nanobodies are the smallest fragments of naturally occurring single-domain antibodies that have evolved to be ...
Ghada H Shaker
doaj  

Diphtheria toxin-derived, anti-PD-1 immunotoxin, a potent and practical tool to selectively deplete PD-1⁺ cells. [PDF]

Protein Sci, 2023
Zhang T, Dong S, Zhai Y, Naatz L, Zhou Z, Chen M.   +5 more
europepmc   +1 more source

Characterization and cytotoxicity properties of a diphtheria toxin-neurotrophin-4-fusion protein fused to diphtheria toxin

, 1997
A diphtheria toxin-neurotrophin-4/5 (NT-4/5) chimera (DAB389-NT4), in which the native receptor binding domain of diphtheria toxin was replaced with a synthetic gene encoding rat NT-4/5, was expressed, refolded, and purified.
NEGRO, ALESSANDRO, AND SKAPER S. D.
core  

A novel murine model of atrial fibrillation by diphtheria toxin-induced injury. [PDF]

Front Physiol, 2022
Trieu T, Mach P, Bunn K, Huang V, Huang J, Chow C, Nakano H, Fajardo VM, Touma M, Ren S, Wang Y, Nakano A.   +11 more
europepmc   +1 more source

DETERMINATION OF DIPHTHERIA-TOXIN NEUTRALIZING ANTIBODY-TITERS WITH A CELL PROTEIN-SYNTHESIS INHIBITION ASSAY

, 1991
A method which allows an accurate determination of very low titers of antibodies able to neutralize diphtheria toxin has been developed. The assay is based on the incubation of a reference amount of diphtheria toxin with different dilution of the serum ...
RAPPUOLI R, MONTECUCCO, CESARE, PADOVAN E, PAPINI, EMANUELE   +3 more
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