Results 91 to 100 of about 71,467 (221)

Late Presentation of Post Diphtheritic Myocarditis in a 15-year male

Journal of Nepal Medical Association, 2017
A 15-year old male patient presented to us with dyspnoea for four days. He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation.
Kutty Sharada Vinod, Nitin Gupta, Harsh Sahu, Naveet Wig   +3 more
doaj   +1 more source

Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice

, 2010
Current therapies to treat prostate cancer are often limited. Since it has been shown that very low concentrations of diphtheria toxin A (DT-A) result in abrogation of protein synthesis and apoptosis of cells, DT-A might serve as an efficient killer in ...
Goepfert, Christine, Amiq Gazdhar, Brigitte M. Frey, Felix J. Frey, Frey, Felix J, Christine Goepfert, Frey, Brigitte M, Gazdhar, Amiq   +7 more
core   +1 more source

Ion channel and membrane translocation of diphtheria toxin

, 1992
Diphtheria toxin is the best studied member of a family of bacterial protein toxins which act inside cells. To reach their cytoplasmic targets, these toxins, which include tetanus and botulinum neurotoxins and anthrax toxin, have to cross the hydrophobic
MONTECUCCO, CESARE, ROSSETTO, ORNELLA, PADOVAN E, PAPINI, EMANUELE, SCHIAVO G   +4 more
core   +1 more source

Interaction of diphtheria toxin (fragment A) with actin

Cell Biochemistry and Function, 2009
AbstractIt was shown by gel filtration and viscosity measurements that N‐terminal fragment (FA) of diphtheria toxin (DT) can interact with both G‐ and F‐actin (filamentous actin). Elution profiles on Sephadex G‐100 indicated the formation of a binary complex of fragment A (FA) with globular actin monomer (G‐actin), which was inhibited by gelsolin ...
Bektas, Muhammet, Varol, Basak, Nurten, Ruestem, Bermek, Engin   +3 more
openaire   +4 more sources

Characterization and cytotoxicity properties of a diphtheria toxin-neurotrophin-4-fusion protein fused to diphtheria toxin

, 1997
A diphtheria toxin-neurotrophin-4/5 (NT-4/5) chimera (DAB389-NT4), in which the native receptor binding domain of diphtheria toxin was replaced with a synthetic gene encoding rat NT-4/5, was expressed, refolded, and purified.
NEGRO, ALESSANDRO, AND SKAPER S. D.
core  

Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical ...
Mohaddeseh Parvand, Fahimeh Nemati Mansour, Jafar Amani   +2 more
doaj  

The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. [PDF]

, 2008
We investigated the effect of carriage of Staphylococcus aureus in the later stages of pregnancy on levels of antibody specific to the S. aureus toxins, staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC) and toxic shock syndrome toxin-
Morris, James A., Telford, David R., Lauder, Robert M., Harrison, Linda M.   +3 more
core  

Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model

, 2017
Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon equine diphtheria anti-toxin (DAT), with a 10% risk of serum sickness and rarely anaphylaxis.
Leney, Mark, Barton, Bruce A, Smith, Heidi L., Molrine, Deborah C., Cheslock, Peter S.   +4 more
core   +1 more source

Gene therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria toxin gene delivered by a novel adenovirus-polylysine conjugate [PDF]

, 1994
Deborah R. Cook, Ian H. Maxwell, Purner, M. B., L. Michael Glode, Maxwell, F., Stevens, J. O., Matthew B. Purner, Curiel, Tyler J., Wagner, Ernst, Ernst Wagner, David T. Curiel, Maxwell, I. H., Tyler J. Curiel, Curiel, David T., Cook, Deborah R., James O. Stevens, Francoise Maxwell, Glode, L. M.   +17 more
core   +1 more source

HISTIDINE-21 IS INVOLVED IN DIPHTHERIA-TOXIN NAD+ BINDING

, 1990
Histidine-21 is the sole histidine present in the A chain of diphtheria toxin and recent evidence suggests that it is involved in NAD+ binding. Fluorimetric assays of NAD+ binding and diethylpyrocarbonate modification performed at different pH values ...
MONTECUCCO C., RAPPUOLI R, PAPINI, EMANUELE, SCHIAVO G   +3 more
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