Results 91 to 100 of about 215,613 (217)
On the Toxin Production of the Diphtheria Bacillus [PDF]
Epidemiology and Infection, 1912 Everyone who has been occupied with the weekly production of diphtheria toxin in quantity has been struck with the great variations which may and usually do occur in the strength of the toxin from week to week. It is indeed extraordinary as Madsen remarks (1908, p.
openaire +2 more sources
Diphtheria toxin-based efficient target-switchable anticancer drug
, 2018 Recombinant immunotoxins (RITs) have been extensively utilized in the field of targeted cancer therapy. RITs are composed of toxins derived from natural bacterial strains and antibodies for target specific killing of cancer cells.
Choi, Bonseo +3 more
core
proHB-EGF를 발현하는 형이전환 쥐를 만들어 Diphtheria toxin의 동물실험
, 2003 Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until ...
차정헌
core +1 more source
Proteolytic activity of diphtheria toxin
, 2005 Purified samples of diphtheria toxin spitted human fibrinogen, human serum albumin and gelatin. Splitting was completely inhibited by nitrotetrazolium blue (0.01 mol) but no other active oxygen species.
Пыжова, Н.С. +3 more
core
Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids
, 1987 The interaction of diphtheria toxin and its enzymatically deficient mutants crm 176 and crm 197 with liposomes has been studied by turbidity measurement and hydrophobic photolabelling with photoactivatable phosphatidylcholines.
Cesare Montecucco +13 more
core +1 more source
Identification of Formaldehyde-Induced Modifications in Diphtheria Toxin
, 2020 Diphtheria toxoid is produced by detoxification of diphtheria toxin with formaldehyde. This study was performed to elucidate the chemical nature and location of formaldehyde-induced modifications in diphtheria toxoid.
Michiels, Thomas +11 more
core
, 2016 The Td-based combined vaccine contains only small amounts of the diphtheria toxoid antigen. However, a high level of purity is necessary for this antigen.
T Y Kim +13 more
core +1 more source
Inactivation of diphtheria toxin by site-directed mutagenesis
Diphtheria toxin is a single polypeptide chain produced by toxigenic strains of Corynebacterium diphtheriae that causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis.
Prijić, Ivana +7 more
core +1 more source
HISTIDINE-21 IS INVOLVED IN DIPHTHERIA-TOXIN NAD+ BINDING
, 1990 Histidine-21 is the sole histidine present in the A chain of diphtheria toxin and recent evidence suggests that it is involved in NAD+ binding. Fluorimetric assays of NAD+ binding and diethylpyrocarbonate modification performed at different pH values ...
MONTECUCCO C. +3 more
core
Topology of diphtheria toxin B fragment inserted in lipid vesicles
, 1994 Diphtheria toxin (DT) is a bacterial protein that crosses the membrane of endosomes of target cells in response to the low endosomal pH. In this paper, we have inserted diphtheria toxin in asolectin vesicles at pH 5.0 and treated the reconstituted system
Carina Capiau +11 more
core +1 more source