Results 91 to 100 of about 404,518 (216)

Observations on the Structure of Diphtheria Toxin

Journal of Biological Chemistry, 1971
Diphtheria toxin is synthesized as a single polypeptide chain with a molecular weight of about 62,000. After being secreted it may be partially digested by proteolytic enzymes released from the bacterial cells into the culture medium and purified preparations of toxin usually contain some of the proteolytic breakdown products.
D M, Gill, L L, Dinius
openaire   +2 more sources

On the Toxin Production of the Diphtheria Bacillus [PDF]

Epidemiology and Infection, 1912
Everyone who has been occupied with the weekly production of diphtheria toxin in quantity has been struck with the great variations which may and usually do occur in the strength of the toxin from week to week. It is indeed extraordinary as Madsen remarks (1908, p.
openaire   +2 more sources

Characterization of a transgenic mouse model of chronic conditional platelet depletion

Research and Practice in Thrombosis and Haemostasis, 2019
Background Platelets are widely recognized for their role in maintaining hemostasis. Recently, platelets have become appreciated for their varying roles in immunity, neuroprotection, and other physiological processes.
Leah M. Wuescher, Sharmeen Nishat, Randall G. Worth   +2 more
doaj   +1 more source

Late Presentation of Post Diphtheritic Myocarditis in a 15-year male

Journal of Nepal Medical Association, 2017
A 15-year old male patient presented to us with dyspnoea for four days. He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation.
Kutty Sharada Vinod, Nitin Gupta, Harsh Sahu, Naveet Wig   +3 more
doaj   +1 more source

CONFORMATIONAL SWITCHING OF THE DIPHTHERIA TOXIN T-DOMAIN

Journal of Molecular Biology, 2010
The diphtheria toxin T-domain translocates the catalytic C-domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of the T-domain, we have used site ...
M. Rodnin, A. Kyrychenko, P. Kienker, O. Sharma, Y. Posokhov, R. John Collier, A. Finkelstein, A. Ladokhin   +7 more
semanticscholar   +1 more source

Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

Journal of Translational Medicine, 2010
BackgroundThe human IGF2-P4 and H19 promoters are highly active in a variety of human cancers (including bladder cancer), while existing at a nearly undetectable level in the surrounding normal tissue.Single promoter vectors expressing diphtheria toxin A-
D. Amit, A. Hochberg
semanticscholar   +1 more source

Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical ...
Mohaddeseh Parvand, Fahimeh Nemati Mansour, Jafar Amani   +2 more
doaj  

Severe faucial diphtheria with myocarditis: a case report

Zdorovʹe Rebenka
Background. Diphtheria is a potentially fatal contagious disease caused by toxigenic strains, characterized by inflammation of the upper respiratory tract mucosa, and may further generate toxicity in the myocardium and peripheral nerve.
Gabriella Tandipayuk, Seruni Estari, Dominicus Husada, Leny Kartina, Dwiyanti Puspitasari   +4 more
doaj   +1 more source

Properties of the left ventricular myocardium structure in experimental acute diphtheria intoxication

RUDN Journal of Medicine, 2014
Diphtheria is considered to be vaccine-preventable disease due to organized immunization programmes. However there are still endemic regions of diphtheria, whence reports of mortal cases are coming.
A Ju Korshunova, M L Blagonravov, V A Frolov, M M Azova   +3 more
doaj  

Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain. [PDF]

Toxins (Basel), 2023
Rodnin MV, Vasques-Montes V, Kyrychenko A, Oliveira NFB, Kashipathy MM, Battaile KP, Douglas J, Lovell S, Machuqueiro M, Ladokhin AS.   +9 more
europepmc   +1 more source