Results 81 to 90 of about 215,613 (217)

Observations on the Structure of Diphtheria Toxin

Journal of Biological Chemistry, 1971
Diphtheria toxin is synthesized as a single polypeptide chain with a molecular weight of about 62,000. After being secreted it may be partially digested by proteolytic enzymes released from the bacterial cells into the culture medium and purified preparations of toxin usually contain some of the proteolytic breakdown products.
D M, Gill, L L, Dinius
openaire   +2 more sources

Microevolution and genomic epidemiology of the diphtheria-causing zoonotic pathogen Corynebacterium ulcerans

Nature Communications
Corynebacterium ulcerans is an emerging zoonotic pathogen which causes diphtheria-like infections. Although C. ulcerans is found in multiple domestic and wild animal species, most human cases are linked with pets.
Chiara Crestani, Virginie Passet, Martin Rethoret-Pasty, Nora Zidane, Sylvie Brémont, Edgar Badell, Alexis Criscuolo, Sylvain Brisse   +7 more
doaj   +1 more source

Diphtheria.

, 2020
Diphtheria is a potentially fatal infection mostly caused by toxigenic Corynebacterium diphtheriae strains and occasionally by toxigenic C. ulcerans and C. pseudotuberculosis strains.

core   +2 more sources

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Functional verification of the diphtheria toxin A gene in a recombinant system

Journal of Animal Science and Biotechnology, 2012
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng, Wei Hengxi, Guo Xinzheng, Hu Minghua, Gao Fenglei, Li Li, Zhang Shouquan   +6 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Ion channel and membrane translocation of diphtheria toxin

, 1992
Diphtheria toxin is the best studied member of a family of bacterial protein toxins which act inside cells. To reach their cytoplasmic targets, these toxins, which include tetanus and botulinum neurotoxins and anthrax toxin, have to cross the hydrophobic
MONTECUCCO, CESARE, ROSSETTO, ORNELLA, PADOVAN E, PAPINI, EMANUELE, SCHIAVO G   +4 more
core   +1 more source

Persistent Pelvic Adhesions and Fibrotic Remodeling Following Ectopic Lesion Ablation in a Mouse Model of Endometriosis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
DT‐mediated ablation eliminated detectable donor‐derived ectopic lesions. However, pelvic adhesions, collagen‐rich fibrosis, α‐SMA‐positive fibrotic remodeling, and functional behavioral alterations persisted. These findings indicate that lesion ablation alone is insufficient to resolve established adhesion‐associated fibrotic remodeling and identify ...
Sohyeon Yun, Kyeong A. So, Eunhee M. Jeong, Marissa G. Hoover, Abu Raihan, Lisa Brennaman, Jung‐Yoon Yoo, Andrew M. Kelleher, Tae Hoon Kim, Jung‐Ho Shin, Jae‐Wook Jeong   +10 more
wiley   +1 more source

Two Blastic Plasmacytoid Dendritic Cell Neoplasms treated with the CD123‐targeted agent Tagraxofusp presenting divergent outcomes

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Sven C. Engler, Elisabeth M. Walde, Edgar Jost, Amir S. Yazdi, David Kluwig   +4 more
wiley   +1 more source

Effect of monophosphoryl lipid A on antibody response to diphtheria toxin and its subunits

, 2005
Caglar K, Aybay C, Ataoglu H. Effect of monophosphoryl lipid A on antibody response to diphtheria toxin and its subunits.
Caglar, K, KAYHAN CAGLAR, CEMALETTIN AYBAY, Aybay, C, HALUK ATAOGLU, Ataoglu, H   +5 more
core   +1 more source