Results 81 to 90 of about 87,166 (220)

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley   +1 more source

Computational structure-based identification of silymarin as a promising flavonoid inhibitor of the diphtheria toxin catalytic domain

Discover Chemistry
Diphtheria toxin, a major virulence factor of Corynebacterium diphtheriae, continues to pose significant therapeutic challenges in the face of antimicrobial resistance. Flavonoids, owing to their structural diversity and bioactivity, represent attractive
Chidi Edbert Duru, Favour Ogadinma Izuagba, Ijeoma Akunna Duru, Tochukwu Ifeanyi Nwakile, Chukwuebuka Daniel Nwadike   +4 more
doaj   +1 more source

High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia [PDF]

, 1998
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV‐8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS). Prevalence of antibodies to HHV‐8 sVCA
Angeloni, Antonio, Cerimele, Decio, Cottoni, Francesca Maria Giovanna, Faggioni, Alberto, Heston, Lee, Lin, Su-Fang, Masala, Maria Vittoria, Miller, George, Rigsby, Michael, Sirianni, Maria Caterina, Sun, Ren, Uccini, Stefania   +11 more
core   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, Volume 116, Issue 4, Page 336-349, April 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source

Functional verification of the diphtheria toxin A gene in a recombinant system

Journal of Animal Science and Biotechnology, 2012
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng, Wei Hengxi, Guo Xinzheng, Hu Minghua, Gao Fenglei, Li Li, Zhang Shouquan   +6 more
doaj   +1 more source

Path Similarity Analysis: a Method for Quantifying Macromolecular Pathways

, 2015
Diverse classes of proteins function through large-scale conformational changes; sophisticated enhanced sampling methods have been proposed to generate these macromolecular transition paths. As such paths are curves in a high-dimensional space, they have
Beckstein, Oliver, Kumar, Avishek, Seyler, Sean L., Thorpe, Michael F.   +3 more
core   +3 more sources

Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll‐Like Receptor Stimulation Through MyD88

Scandinavian Journal of Immunology, Volume 103, Issue 4, April 2026.
Despite their importance, dendritic cell subsets are not well characterised in neonates. We here provide fundamental information on the abundance and phenotype of small‐intestinal neonatal DCs and assess the role of MyD88 in neonatal and adult DC migration in response to several toll‐like receptor ligands.
Konjit Getachew Muleta, Signe Holst, Agnès Garcias López, Sayoni Chakraborty, Clement da Silva, Adam F. Cunningham, Isabel Ulmert, Joy Nakawesi, Julia Hütter, Katharina Lahl   +9 more
wiley   +1 more source

Microevolution and genomic epidemiology of the diphtheria-causing zoonotic pathogen Corynebacterium ulcerans

Nature Communications
Corynebacterium ulcerans is an emerging zoonotic pathogen which causes diphtheria-like infections. Although C. ulcerans is found in multiple domestic and wild animal species, most human cases are linked with pets.
Chiara Crestani, Virginie Passet, Martin Rethoret-Pasty, Nora Zidane, Sylvie Brémont, Edgar Badell, Alexis Criscuolo, Sylvain Brisse   +7 more
doaj   +1 more source

HLA Class II Protein Expression Regulation Is Strongly Linked to Cis‐Acting SNPs

HLA, Volume 107, Issue 4, April 2026.
ABSTRACT Allele‐specific variability in HLA class I gene expression levels has been associated with many diseases. Although expression variation at the allelic level has not been well‐characterised for the HLA class II genes, differential expression of these genes, as marked by single nucleotide polymorphisms (SNPs), has been implicated in the outcome ...
Nicolas Vince, Veron Ramsuran, Mathias Viard, Jeremy Martinson, Steven Wolinsky, Shehnaz Hussain, Eric C. Seaberg, Todd T. Brown, Niamh Spence, Chloe L. Thio, James J. Goedert, W. Keith Hoots, Gregory D. Kirk, Mary Carrington   +13 more
wiley   +1 more source