Results 81 to 90 of about 542,716 (249)

The Terminator mouse is a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages

Kidney International, 2013
Biomedical research often requires primary cultures of specific cell types, which are challenging to obtain at high purity in a reproducible fashion. Here we engineered the murine Rosa26 locus by introducing the diphtheria toxin receptor flanked by loxP ...
Jiankan Guo, Hongmei Shi, Farrukh Koraishy, A. Marlier, Zhaowei Ding, Alan Shan, L. Cantley   +6 more
semanticscholar   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Diphtheria toxin has the properties of a lectin [PDF]

, 1978
The inhibition of protein synthesis in Chinese hamster V79 cells by diphtheria toxin is antagonized by the lectins concanavalin A, succinylated concanavalin A, and wheat germ agglutinin but not by Proteus vulgaris phytohemagglutinin or abrus agglutinin ...
Chin, Daniel, Draper, Rockford K., Simon, Melvin I.   +2 more
core  

Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia

Emerging Infectious Diseases, 2017
By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria.
Christine J. Doyle, Adam Mazins, Rikki M.A. Graham, Ning-Xia Fang, Helen V. Smith, Amy V. Jennison   +5 more
doaj   +1 more source

Kinetics of Diphtheria Toxin Formation [PDF]

Journal of General Microbiology, 1962
SUMMARY: Studies on the kinetics of diphtheria toxin formation in iron-free culture media by variants of the PW no. 8 strain of Corynebacterium diphtheriae labelled with 14C-phenylalanine or 35S-methionine, showed that the toxin protein was synthesized de novo from amino acids by growing organisms.
A M, PAPPENHEIMER, P A, MILLER, M, YONEDA   +2 more
openaire   +2 more sources

TOXIN-ANTITOXIN IMMUNIZATION AGAINST DIPHTHERIA

, 1922
The development of antitoxin in the bodies of animals injected with diphtheria toxin is one of the best established of facts. Since von Behring and Roux announced the results of their investigations, large numbers of horses have been injected with toxin ...
W. H. Park
semanticscholar   +1 more source

Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin

Journal of Neuroscience, 2012
We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes a hair cell-specific transcription ...
Justin S. Golub, Ling Tong, Tot B. Ngyuen, C. Hume, R. Palmiter, E. Rubel, Jennifer S. Stone   +6 more
semanticscholar   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Antigen depot is not required for alum adjuvanticity [PDF]

, 2011
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation
Benson, R.A., Hutchison, S., Gibson, V.B., Vivienne B. Gibson, Garside, P., Sharon Hutchison, Paul Garside, James M. Brewer, Robert A. Benson, Brewer, J.M., Pollock, A.H., Abigail H. Pollock   +11 more
core   +1 more source