Results 81 to 90 of about 71,467 (221)

Transcranial Calcium Macro‐Imaging From the Auditory Cortex of Thy1‐Cre‐Driven GCaMP8 Transgenic Rats

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi, Hisaaki Namba, Meiko Kawamura, Ryuichi Hishida, Shota Iguchi, Kazuto Kobayashi, Natsuki Matsushita, Tomoji Mashimo, Rie Natsume, Kenji Sakimura, Hiroyuki Nawa   +10 more
wiley   +1 more source

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, Volume 3, Issue 2, Page 76-86, June 2026.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Proteolytic activity of diphtheria toxin

, 2005
Purified samples of diphtheria toxin spitted human fibrinogen, human serum albumin and gelatin. Splitting was completely inhibited by nitrotetrazolium blue (0.01 mol) but no other active oxygen species.
Пыжова, Н.С., Pyzhova, N.S., Nikandrov, V.N., Никандров, В.Н.   +3 more
core  

Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice

, 2012
The role of resident renal mononuclear phagocytes in acute kidney injury is controversial with experimental data suggesting both deleterious and protective functions.
Dhaliwal, Kevin, Kipari, Tiina M.J., Sheldrake, Tara A., Hughes, Jeremy, Ferenbach, David A., Kluth, David C., Marson, Lorna P.   +6 more
core   +1 more source

A Case for Anti‐IgE Vaccination

Allergy, Volume 81, Issue 6, Page 2001-2013, June 2026.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Optimization of diphtheria toxin production by Corynebacterium diphtheriae using a casein-based medium in a fermenter

, 2016
The Td-based combined vaccine contains only small amounts of the diphtheria toxoid antigen. However, a high level of purity is necessary for this antigen.
T Y Kim, Sang-Mi Lee, S M Lee, Yong Kyung Choe, I H Kim, Yong-Ju Chung, Jin-A Lee, Mi-Young Jung, Y J Chung, Tae-Yeon Kim, Ik-Hwan Kim, M Y Jung, Yong-Kyung Choe, J A Lee   +13 more
core   +1 more source

Computational design of novel diphtheria toxin inhibitors using natural products-based drug discovery

The Microbe
Background of study: Diphtheria, caused by Corynebacterium diphtheriae, is still a major global health concern, especially in resource-limited settings.
Adedoyin John-Joy Owolade, Damilola Bodun, Elijah Orimisan Akinbi, Samson Ayorinde Oni, Jeremiah Oluwamayowa Omojuyigbe, Taiwo Waris Olatunji, Ani Chibuike Sylvanus, Ayodele Emmanuel Oke   +7 more
doaj   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source

Characterization of a transgenic mouse model of chronic conditional platelet depletion

Research and Practice in Thrombosis and Haemostasis, 2019
Background Platelets are widely recognized for their role in maintaining hemostasis. Recently, platelets have become appreciated for their varying roles in immunity, neuroprotection, and other physiological processes.
Leah M. Wuescher, Sharmeen Nishat, Randall G. Worth   +2 more
doaj   +1 more source