Results 81 to 90 of about 404,518 (216)

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors

Acta Crystallographica Section D, Volume 82, Issue 8, Page 998-1008, August 2026.
Replacement soaking, also known as cross‐soaking, is a compelling method for solving complex structures in cases where traditional soaking and co‐crystallization approaches fail. This method is demonstrated with human tankyrase 2, and new crystal structures of complexes with nanomolar inhibitors and an analogue of the substrate NAD+ are reported ...
Johan Pääkkönen, Sven T. Sowa, Chiara Bosetti, Lari Lehtiö   +3 more
wiley   +1 more source

Microevolution and genomic epidemiology of the diphtheria-causing zoonotic pathogen Corynebacterium ulcerans

Nature Communications
Corynebacterium ulcerans is an emerging zoonotic pathogen which causes diphtheria-like infections. Although C. ulcerans is found in multiple domestic and wild animal species, most human cases are linked with pets.
Chiara Crestani, Virginie Passet, Martin Rethoret-Pasty, Nora Zidane, Sylvie Brémont, Edgar Badell, Alexis Criscuolo, Sylvain Brisse   +7 more
doaj   +1 more source

Functional verification of the diphtheria toxin A gene in a recombinant system

Journal of Animal Science and Biotechnology, 2012
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng, Wei Hengxi, Guo Xinzheng, Hu Minghua, Gao Fenglei, Li Li, Zhang Shouquan   +6 more
doaj   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, Volume 115, Issue 8, Page 1646-1653, August 2026.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source

Improved Specificity of a Multiplex Immunoassay for Quantitation of Anti-Diphtheria Toxin Antibodies with the Use of Diphtheria Toxoid

Clinical and Vaccine Immunology, 2011
A nonspecific binding of antibodies to diphtheria toxin, especially in adult serum samples, was observed in our diphtheria-tetanus-pertussis multiplex immunoassay (DTaP4 MIA). This can be significantly reduced by the use of diphtheria toxoid, achieving a
P. V. van Gageldonk, C. von Hunolstein, F. R. van der Klis, G. Berbers   +3 more
semanticscholar   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4836-4854, August 2026.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

A Case of Diphtheria

Sri Lankan Journal of Infectious Diseases, 2011
Diphtheria is a nearly eradicated disease in Sri Lanka. After introduction of EPI vaccination program in 1978 childhood diphtheria has been eradicated.
Rohitha Jayamaha
doaj   +1 more source

Development of a diphtheria toxin based anti-porcine CD3 recombinant immunotoxin

Bioconjugate chemistry, 2011
Anti-CD3 immunotoxins, which induce profound but transient T cell depletion in vivo by inhibiting eukaryotic protein synthesis in CD3+ cells, are effective reagents in large animal models of transplantation tolerance and autoimmune disease therapy.
Zhirui Wang, Raimon Duran‐Struuck, R. Crepeau, A. Matar, I. Hanekamp, Srimathi Srinivasan, D. Neville, D. Sachs, Christene A. Huang   +8 more
semanticscholar   +1 more source

Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process

Toxins, 2011
Research on diphtheria and anthrax toxins over the past three decades has culminated in a detailed understanding of their structure function relationships (e.g., catalytic (C), transmembrane (T), and receptor binding (R) domains), as well as the ...
J. Murphy
semanticscholar   +1 more source

Computational design of novel diphtheria toxin inhibitors using natural products-based drug discovery

The Microbe
Background of study: Diphtheria, caused by Corynebacterium diphtheriae, is still a major global health concern, especially in resource-limited settings.
Adedoyin John-Joy Owolade, Damilola Bodun, Elijah Orimisan Akinbi, Samson Ayorinde Oni, Jeremiah Oluwamayowa Omojuyigbe, Taiwo Waris Olatunji, Ani Chibuike Sylvanus, Ayodele Emmanuel Oke   +7 more
doaj   +1 more source