Results 71 to 80 of about 71,467 (221)
On the Toxin Production of the Diphtheria Bacillus [PDF]
Epidemiology and Infection, 1912 Everyone who has been occupied with the weekly production of diphtheria toxin in quantity has been struck with the great variations which may and usually do occur in the strength of the toxin from week to week. It is indeed extraordinary as Madsen remarks (1908, p.
openaire +2 more sources
ChemNanoMat, Volume 12, Issue 6, June 2026.Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo +3 more
wiley +1 more source
pH-dependent energy profile of diphtheria toxin (1DDT).
, 2015 pH-dependent energy profile of diphtheria toxin (1DDT).
Prashant Shingate (146643) +2 more
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Nature CommunicationsCorynebacterium ulcerans is an emerging zoonotic pathogen which causes diphtheria-like infections. Although C. ulcerans is found in multiple domestic and wild animal species, most human cases are linked with pets.
Chiara Crestani +7 more
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Functional verification of the diphtheria toxin A gene in a recombinant system
Journal of Animal Science and Biotechnology, 2012 Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng +6 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This study explores the interaction between Diphtheria Toxin (DT) and Bcl‐2 in HT‐29 cells. Integrating molecular docking with gene expression analysis, we demonstrate DT's high‐affinity binding to Bcl‐2 and a significant downregulation of BCL2 mRNA. These findings suggest that DT modulates anti‐apoptotic pathways, influencing colorectal cancer cell ...
Elif Ercan +3 more
wiley +1 more source
Observations on the Structure of Diphtheria Toxin
Journal of Biological Chemistry, 1971 Diphtheria toxin is synthesized as a single polypeptide chain with a molecular weight of about 62,000. After being secreted it may be partially digested by proteolytic enzymes released from the bacterial cells into the culture medium and purified preparations of toxin usually contain some of the proteolytic breakdown products.
D M, Gill, L L, Dinius
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Engineered Nestin+ TSPC‐Derived Exosomes Promote Tendon Repair Via Metabolic Reprogramming
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.Engineered Nestin+ TSPC‐derived exosomes promote tendon repair by reprogramming tenocyte metabolism via the pantothenate‐CoA‐mitochondria axis. They enhance mitochondrial function, reduce senescence and oxidative stress, restoring tendon structure and function in injured and aged models.
Linxiang Cheng +8 more
wiley +1 more source
Diphtheria toxin-based efficient target-switchable anticancer drug
, 2018 Recombinant immunotoxins (RITs) have been extensively utilized in the field of targeted cancer therapy. RITs are composed of toxins derived from natural bacterial strains and antibodies for target specific killing of cancer cells.
Choi, Bonseo +3 more
core
Sri Lankan Journal of Infectious Diseases, 2011 Diphtheria is a nearly eradicated disease in Sri Lanka. After introduction of EPI vaccination program in 1978 childhood diphtheria has been eradicated.
Rohitha Jayamaha
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