Results 51 to 60 of about 404,518 (216)

Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria

Human Vaccines & Immunotherapeutics, 2017
There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics.
Heidi L. Smith, Greg Saia, Maria Lobikin, Tejpratap Tiwari, Su-Chun Cheng, Deborah C. Molrine   +5 more
doaj   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Kinetics of Diphtheria Toxin Formation [PDF]

Journal of General Microbiology, 1962
SUMMARY: Studies on the kinetics of diphtheria toxin formation in iron-free culture media by variants of the PW no. 8 strain of Corynebacterium diphtheriae labelled with 14C-phenylalanine or 35S-methionine, showed that the toxin protein was synthesized de novo from amino acids by growing organisms.
A M, PAPPENHEIMER, P A, MILLER, M, YONEDA   +2 more
openaire   +2 more sources

pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain

Toxins, 2013
The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification.
A. Ladokhin
semanticscholar   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Surveillance of diphtheria in the Netherlands between 2000–2021: cutaneous diphtheria supersedes the respiratory form

BMC Infectious Diseases, 2023
Background Diphtheria is a severe respiratory or cutaneous infectious disease, caused by exotoxin producing Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Diphtheria is once again prevalent due to breakdown of immunisation programmes,
Jelte Elsinga, Dimphey van Meijeren, Frans Reubsaet   +2 more
doaj   +1 more source

ADP-ribosylation of Translation Elongation Factor 2 by Diphtheria Toxin in Yeast Inhibits Translation and Cell Separation*

Journal of Biological Chemistry, 2013
Background: Diphtheria toxin inhibits translation by ADP-ribosylation of elongation factor 2. Results: Diphtheria toxin expression results in accumulation of cells that fail to separate following mitosis.
M. Mateyak, T. Kinzy
semanticscholar   +1 more source

Genome Analysis of Corynebacterium ulcerans Isolates Chronologically Recovered From the Same Cat for Two Years: Circulation in a Cat Shelter

Microbiology and Immunology, EarlyView.
ABSTRACT Toxigenic Corynebacterium ulcerans, a zoonotic pathogen, was isolated repeatedly from a cat in an in‐house group in Japan. Although the cat was cured once by antibiotic treatment, clonal isolates of the original pathogenic strain were recovered repeatedly during a 2‐year course.
Ryoko Jikihara, Miyuki Kimura, Hyun Kim, Tsuyoshi Sekizuka, Masatomo Morita, Makoto Kuroda, Akihiko Yamamoto, Mitsutoshi Senoh, Masaaki Iwaki   +8 more
wiley   +1 more source

Current state of methods for control the safety and potency of diphtheria toxoid and tetanus toxoid in combined vaccines

Эпидемиология и вакцинопрофилактика, 2022
Relevance. Diphtheria toxoid (DT) and tetanus toxoid (TT) manufacturing appears as many steps process. On every stage of proceeding vaccine the control of critical points is being provided.
E. I. Komarovskaya, O. V. Perelygyna
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source