Results 51 to 60 of about 215,613 (217)

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
core   +2 more sources

Oral Astilbin Nanogels Modulate Senescence‐Associated CD4+ T Cells and Promote Treg Induction in Aged Mice with Colitis

Advanced Science, EarlyView.
Fluorinated β‐glucan/pectin nanogels enable colon‐targeted oral delivery of astilbin through gastrointestinal protection, β‐glucanase‐responsive release, mucus penetration, and prolonged retention. The released astilbin attenuates senescence‐associated features of CD4+ T cells and promotes Treg responses, while the nanogel matrix modulates the gut ...
Lei Zhao, Xinyun Zhang, Qian Ren, Xue Song, Meifang Zhao, Rongshen Wang, Haocheng Du, Yan Chen, Peigen Xu, Jiangyun Liu, Jian Zhang, Jingjing Ma   +11 more
wiley   +1 more source

SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIC-CO-GLYCOLIC)ACID MICROPARTICLES LOADED BY DIPHTHERIA TOXOID [PDF]

Biotechnologia Acta, 2018
The aim of the study was to synthesize poly(D,L-lactide-co-glycolide) particles — PLGA and obtain their complexes with a non-toxic diphtheria toxin recombinant fragment subunit B fused with enhanced green fluorescent protein EGFP-SubB; to characterize ...
T. O. Chudina, V. A. Skoryk, E. I. Legach   +2 more
doaj   +1 more source

Whole-genome sequencing data of Corynebacterium diphtheriae isolated from diphtheria outbreaks in Indonesia

Data in Brief, 2022
Corynebacterium diphtheriae (C. diphtheriae) is the causative agent of diphtheria. The main virulence factor of C. diphtheriae is diphtheria toxin, which is encoded by the tox gene and regulated by the dtxR gene.
Vivi Setiawaty, Nelly Puspandari, Ratih Dian Saraswati, Dwi Febriyana, Tati Febrianti, Yuni Rukminiati, Fauzul Muna, Fitriana Fitriana, Dodi Safari, Rahadian Pratama, Lisa Andriani Lienggonegoro, Sunarno Sunarno   +11 more
doaj   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

The Action of Diphtheria Toxin on Mice [PDF]

Journal of Hygiene, 1922
1. For the particular toxin tested, the intravenous m.l.d. for mice was 60 times and the intramuscular m.l.d. for mice 100 times, the guinea-pig sub cutaneous m.l.d.2. Antitoxin has the same neutralising power for toxin in mice as in guinea-pigs.
A T, Glenny, K, Allen
openaire   +2 more sources

Methods of control diphtheria vaccine safety

Annals of Mechnikov's Institute, 2020
Vaccination success depends not only on the timely coverage of threatened contingents, but also on the quality of vaccines. Every day, the requirements for security guarantees vaccines and their use guarantees of security increases.
Ye Isayenko, Ye Babych, I Yelyseyeva, L Zhdamarova, V Belozersky, S Kolpak   +5 more
doaj