Results 51 to 60 of about 542,716 (249)

Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells

Journal of Immunology, 2014
Plasmacytoid dendritic cells (pDC) produce IFN-I in response to viruses and are routinely identified in mice by SiglecH expression. SiglecH is a sialic acid–binding Ig-like lectin that has an immunomodulatory role during viral infections.
M. Swiecki, Yaming Wang, E. Riboldi, A. Kim, A. Dzutsev, S. Gilfillan, W. Vermi, C. Ruedl, G. Trinchieri, M. Colonna   +9 more
semanticscholar   +1 more source

Transmission of toxigenic Corynebacterium ulcerans infection with airway obstruction from cats to a human

Acute Medicine & Surgery, 2021
Background Infections caused by Corynebacterium ulcerans, a zoonotic pathogen, have been reported worldwide. This microorganism is known to produce the diphtheria toxin and cause diphtheria‐like illness.
Koji Wake, Jin Kikuchi, Masatoshi Uchida, Masato Nemoto, Yoshiyuki Kaji, Tatsuya Yokoyama, Hiromichi Suzuki, Atsuhito Fukushima, Akihiko Yamamoto, Masaaki Iwaki, Kazuyuki Ono   +10 more
doaj   +1 more source

An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs.

Molecules and Cells, 2022
ADP-ribosyltransferases (ARTs) were among the first identified bacterial virulence factors. Canonical ART toxins are delivered into host cells where they modify essential proteins, thereby inactivating cellular processes and promoting pathogenesis.
Nathan P. Bullen, D. Sychantha, Stephanie S. Thang, Peter H. Culviner, Marta Rudzite, Shehryar Ahmad, Vraj S. Shah, A. Filloux, G. Prehna, J. C. Whitney   +9 more
semanticscholar   +1 more source

Identification of a Human Monoclonal Antibody to Replace Equine Diphtheria Anti-toxin for the Treatment of Diphtheria [PDF]

, 2013
Diphtheria anti-toxin (DAT) has been used to treat Corynebacterium diphtheriae infection for over one hundred years. While the global incidence of diphtheria has declined in the 20th century, the disease remains endemic in many parts of the world and ...
Babcock, Gregory J., Wang, Yang, Booth, Brian J., Thomas, William D., Sloan, Susan, Garrity, Kerry A., Sevigny, Leila M., Leav, Brett A., Klempner, Mark S., Rowley, Kirk J., Cheslock, Peter S.   +10 more
core   +1 more source

Studies on the Diphtheria Toxin Receptor

, 1981
¹²⁵ I-Labeled membrane components that specifically interact with diphtheria toxin were detected by two different labeling methods followed by an immunoprecipitation system. These components, which adhere to lentil lectin-agarose columns, were present on
Loverock, Bruce
core   +1 more source

Novel Corynebacterium diphtheriae in domestic cats [PDF]

, 2010
Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic ...
Hans P. Hinrikson, Whitney, Anne M., Maria L. Tondella, Frances Bolt, Bolt, Frances, Bernard, Kathryn A., Steigerwalt, Arnold G., Masaaki Iwaki, Pamela K. Cassiday, Komiya, Takako, Baldwin, Adam, Kathryn A. Bernard, Pawloski, Lucia C., Lucia C. Pawloski, Motohide Takahashi, Danae Bixler, Cassiday, Pamela K., Takahashi, Motohide, Adam Baldwin, Takako Komiya, Tondella, Maria L., Hinrikson, Hans P., Bixler, Danae, Arnold G. Steigerwalt, Dowson, Christopher G., Aron J. Hall, Christopher G. Dowson, Hall, Aron J., Iwaki, M., Anne M. Whitney   +29 more
core   +1 more source

Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island

Genome Medicine, 2014
BackgroundToxigenic Corynebacterium ulcerans can cause a diphtheria-like illness in humans and have been found in domestic animals, which were suspected to serve as reservoirs for a zoonotic transmission. Additionally, toxigenic C. ulcerans were reported
D. Meinel, G. Margos, R. Konrad, S. Krebs, H. Blum, A. Sing   +5 more
semanticscholar   +1 more source

Myofibrillar degeneration with diphtheria toxin

, 2020
Objectives: Cardiac damage in patient with diphtheritic myocarditis is reported as the leading cause of mortality. Diphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects.
Nurten, Rustem, Edis, Bilge, Bektas, Muhammet   +2 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

DETERMINATION OF REGIMES FOR DIPHTHERIA EXOTOXIN MODIFICATION BY CHEMICAL AND PHYSICOCHEMICAL METHODS [PDF]

Annals of Mechnikov's Institute, 2011
The possibility of diphtheria toxoid obtaining using chemical (amino sugars, organic acids) and physicochemical (amino sugars, organic acids, ultrasound, temperature) factors was studied.
Antusheva T.I., Pluhator T.M., Ryabovol O.V., Sklyar N.I., Ryzhkova T.A., Kalinichenko S.V., Babych E.M., Panova C.V.   +7 more
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