Results 31 to 40 of about 404,518 (216)

Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Toxins, 2016
Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell, Ann-Katrin Mittler, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth   +5 more
doaj   +1 more source

The INFLUENCE OF PHYSICAL AND PHYSICOCHEMICAL FACTORS ON IMMUNOBIOLOGICAL properties of diphtheria toxin [PDF]

Annals of Mechnikov's Institute, 2011
The influence of physical (ultrasound, temperature) and physicochemical (formalin, temperature, ultrasound) factors on the immunobiological properties of diphtheria toxin and its modifications was studied.
Katrych V.A., Kovalenko O.I., Sklyar N.I., Ryzhkova T.A., Gorbunov L.V., Ryabovol E.V., Kivva F.V., Babych, E.M., Kalinichenko S.V., Zhdamarova L.A., Bobyreva I.V., Kalinichenko E.O.   +11 more
doaj  

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells

Journal of Immunology, 2014
Plasmacytoid dendritic cells (pDC) produce IFN-I in response to viruses and are routinely identified in mice by SiglecH expression. SiglecH is a sialic acid–binding Ig-like lectin that has an immunomodulatory role during viral infections.
M. Swiecki, Yaming Wang, E. Riboldi, A. Kim, A. Dzutsev, S. Gilfillan, W. Vermi, C. Ruedl, G. Trinchieri, M. Colonna   +9 more
semanticscholar   +1 more source

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source

An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs.

Molecules and Cells, 2022
ADP-ribosyltransferases (ARTs) were among the first identified bacterial virulence factors. Canonical ART toxins are delivered into host cells where they modify essential proteins, thereby inactivating cellular processes and promoting pathogenesis.
Nathan P. Bullen, D. Sychantha, Stephanie S. Thang, Peter H. Culviner, Marta Rudzite, Shehryar Ahmad, Vraj S. Shah, A. Filloux, G. Prehna, J. Whitney   +9 more
semanticscholar   +1 more source

Transmission of toxigenic Corynebacterium ulcerans infection with airway obstruction from cats to a human

Acute Medicine & Surgery, 2021
Background Infections caused by Corynebacterium ulcerans, a zoonotic pathogen, have been reported worldwide. This microorganism is known to produce the diphtheria toxin and cause diphtheria‐like illness.
Koji Wake, Jin Kikuchi, Masatoshi Uchida, Masato Nemoto, Yoshiyuki Kaji, Tatsuya Yokoyama, Hiromichi Suzuki, Atsuhito Fukushima, Akihiko Yamamoto, Masaaki Iwaki, Kazuyuki Ono   +10 more
doaj   +1 more source

Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island

Genome Medicine, 2014
BackgroundToxigenic Corynebacterium ulcerans can cause a diphtheria-like illness in humans and have been found in domestic animals, which were suspected to serve as reservoirs for a zoonotic transmission. Additionally, toxigenic C. ulcerans were reported
D. Meinel, G. Margos, R. Konrad, S. Krebs, H. Blum, A. Sing   +5 more
semanticscholar   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source