Results 31 to 40 of about 215,613 (217)

Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia

Iranian Journal of Microbiology, 2022
Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana, Diana Intan Gabriella Lusiana, Andi Yasmon   +2 more
doaj   +1 more source

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Nature Communications, 2017
Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos   +10 more
doaj   +1 more source

Myofibrillar degeneration with diphtheria toxin

, 2020
Objectives: Cardiac damage in patient with diphtheritic myocarditis is reported as the leading cause of mortality. Diphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects.
Nurten, Rustem, Edis, Bilge, Bektas, Muhammet, ÖZERMAN EDİS, Bilge   +3 more
core   +1 more source

Recombinant Truncated Diphtheria toxin for Possible Therapeutic Applications [PDF]

, 2014
Supervisor: Biplab BoseToxicity of Bacterial toxins , like diphtheria tocin has been widely utilized to create therapeutic agents that can kill target cells.
Kumar, Ashok
core   +1 more source

The INFLUENCE OF PHYSICAL AND PHYSICOCHEMICAL FACTORS ON IMMUNOBIOLOGICAL properties of diphtheria toxin [PDF]

Annals of Mechnikov's Institute, 2011
The influence of physical (ultrasound, temperature) and physicochemical (formalin, temperature, ultrasound) factors on the immunobiological properties of diphtheria toxin and its modifications was studied.
Katrych V.A., Kovalenko O.I., Sklyar N.I., Ryzhkova T.A., Gorbunov L.V., Ryabovol E.V., Kivva F.V., Babych, E.M., Kalinichenko S.V., Zhdamarova L.A., Bobyreva I.V., Kalinichenko E.O.   +11 more
doaj  

Studies on the Diphtheria Toxin Receptor

, 1981
¹²⁵ I-Labeled membrane components that specifically interact with diphtheria toxin were detected by two different labeling methods followed by an immunoprecipitation system. These components, which adhere to lentil lectin-agarose columns, were present on
Loverock, Bruce
core   +1 more source

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Identification of a Human Monoclonal Antibody to Replace Equine Diphtheria Anti-toxin for the Treatment of Diphtheria [PDF]

, 2013
Diphtheria anti-toxin (DAT) has been used to treat Corynebacterium diphtheriae infection for over one hundred years. While the global incidence of diphtheria has declined in the 20th century, the disease remains endemic in many parts of the world and ...
Babcock, Gregory J., Wang, Yang, Booth, Brian J., Thomas, William D., Sloan, Susan, Garrity, Kerry A., Sevigny, Leila M., Leav, Brett A., Klempner, Mark S., Rowley, Kirk J., Cheslock, Peter S.   +10 more
core   +1 more source

Improved Specificity of a Multiplex Immunoassay for Quantitation of Anti-Diphtheria Toxin Antibodies with the Use of Diphtheria Toxoid

, 2011
A nonspecific binding of antibodies to diphtheria toxin, especially in adult serum samples, was observed in our diphtheria-tetanus-pertussis multiplex immunoassay (DTaP4 MIA). This can be significantly reduced by the use of diphtheria toxoid, achieving a
Christina von Hunolstein, Pieter G. M. van Gageldonk, Fiona R. M. van der Klis, Guy A. M. Berbers   +3 more
core   +1 more source