The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement [PDF]
Journal of Cell Biology, 1980 Lysosomotropic amines, such as ammonium chloride, are known to protect cells from the cytotoxic effects of diphtheria toxin. These drugs are believed to inhibit the transport of the toxin from a receptor at the cell exterior into the cytoplasm where a ...
Draper, Rockford K., Simon, Melvin I.
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Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]
Osong Public Health and Research Perspectives, 2018 Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi +7 more
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Investigation of the Effect of PEG Detoxification on Diphtheria Vaccine [PDF]
Archives of Razi Institute, 2022 Immunization has been considered a successful global health program that saves many persons’ lives each year. The vaccines reduce the risk of getting the disease by building immunity in the body. Therefore, the constant availability of essential vaccines
T Hesari +6 more
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SINGLE CHAIN VARIABLE FRAGMENTS OF ANTIBODIES AGAINST DIPHTHERIA TOXIN B-SUBUNIT ISOLATED FROM PHAGE DISPLAY HUMAN ANTIBODY LIBRARY [PDF]
Biotechnologia Acta, 2014 Diphtheria toxin is an exoantigen of Corynebacterium diphtheriae that inhibits protein synthesis and kills sensitive cells. The aim of this study was to obtain human recombinant single-chain variable fragment (scFv) antibodies against receptor-binding B ...
Oliinyk O. S. +3 more
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Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]
, 2008 The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner +32 more
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METHODS OF CONTROL DIPHTHERIA VACCINE SAFETY [PDF]
Annals of Mechnikov's Institute, 2016 Vaccination success depends not only on the timely coverage of threatened contingents, but also on the quality of vaccines. Every day, the requirements for security guarantees vaccines and their use guarantees of security increases.
Isayenko Ye. Yu +5 more
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Novel Corynebacterium diphtheriae in domestic cats [PDF]
, 2010 Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic ...
Hall, Aron J. +14 more
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Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]
, 2018 Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ +10 more
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Diphtheritic myocarditis: A case series and review of literature
Journal of Family Medicine and Primary Care, 2020 Myocarditis in patients with diphtheria is a toxin-mediated complication that sets in after one week of onset of respiratory illness. Early administration of antidiphtheritic serum in patients with clinical diphtheria before the onset of myocarditis is ...
Sonali Singh, Nitin Gupta, Pallavi Saple
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Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia
Iranian Journal of Microbiology, 2022 Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana +2 more
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