Results 21 to 30 of about 542,716 (249)
Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans [PDF]
Emerging Infectious Diseases, 2019 Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans.
Ken Otsuji +3 more
doaj +2 more sources
Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development
Toxins, 2015 Background: Targeted toxins require multiple treatments and therefore must be deimmunized. We report a method of protein deimmunization based on the point mutation of highly hydrophilic R, K, D, E, and Q amino acids on the molecular surface of truncated ...
Daniel Vallera
exaly +2 more sources
Human Vaccines & Immunotherapeutics, 2017 There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics.
Heidi L. Smith +5 more
doaj +3 more sources
Production of IgY polyclonal antibody against diphtheria toxin and evaluation of its neutralization effect by Vero cell assay [PDF]
BMC Biotechnology, 2021 Background Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria.
Morteza Rezaeifard +4 more
doaj +2 more sources
The Journal of Immunology, 1929 Abstract The preparation of diphtheria toxins from the time of its discovery by Behring has been repeatedly investigated with the development of many changes in its preparation, but it still presents many difficulties. The urgent need of strong potent toxins for the Ramon flocculation tests for titration of diphtheria antitoxins, and ...
O. R. Povitzky
openaire +2 more sources
Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain [PDF]
Toxins, 2020 Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin +5 more
doaj +2 more sources
Toxins, 2016 Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell +5 more
doaj +2 more sources
Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis [PDF]
Frontiers in PharmacologyMany bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter human or animal cells and act as enzymes in their cytosol.
Joscha Borho +3 more
doaj +2 more sources
IMMUNOBIOLOGY OF DIPHTHERIA. RECENT APPROACHES FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF DISEASE [PDF]
Biotechnologia Acta, 2013 Diphtheria is a highly contagious life-threatening disease caused by the toxi genic strains of Corynebacterium diphtheria, which are transformed by a bacteriophage carrying the toxin gene.
D. V. Kolybo +6 more
doaj +1 more source