Results 21 to 30 of about 404,518 (216)

Identification of formaldehyde-induced modifications in diphtheria toxin.

Journal of Pharmacy and Science, 2020
Diphtheria toxoid is produced by detoxification of diphtheria toxin with formaldehyde. This study was performed to elucidate the chemical nature and location of formaldehyde-induced modifications in diphtheria toxoid.
B. Metz, T. Michiels, J. Uittenbogaard, Maarten Danial, W. Tilstra, H. Meiring, W. Hennink, D. Crommelin, G. Kersten, W. Jiskoot   +9 more
semanticscholar   +1 more source

SINGLE CHAIN VARIABLE FRAGMENTS OF ANTIBODIES AGAINST DIPHTHERIA TOXIN B-SUBUNIT ISOLATED FROM PHAGE DISPLAY HUMAN ANTIBODY LIBRARY [PDF]

Biotechnologia Acta, 2014
Diphtheria toxin is an exoantigen of Corynebacterium diphtheriae that inhibits protein synthesis and kills sensitive cells. The aim of this study was to obtain human recombinant single-chain variable fragment (scFv) antibodies against receptor-binding B ...
Oliinyk O. S., Kaberniuk A. A., Kolibo D. V., Komisarenko S. V.   +3 more
doaj   +1 more source

Detection and Characterization of Diphtheria Toxin Gene-Bearing Corynebacterium Species through a New Real-Time PCR Assay

Journal of Clinical Microbiology, 2020
Respiratory diphtheria, characterized by a firmly adherent pseudomembrane, is caused by toxin-producing strains of Corynebacterium diphtheriae, with similar illness produced occasionally by toxigenic Corynebacterium ulcerans or, rarely, Corynebacterium ...
Margaret M. Williams, Jessica L. Waller, Janessa Aneke, M. R. Weigand, Maureen H. Diaz, Katherine E. Bowden, Ashley K. Simon, Yanhui Peng, L. Xiaoli, P. Cassiday, J. Winchell, M. Tondella   +11 more
semanticscholar   +1 more source

METHODS OF CONTROL DIPHTHERIA VACCINE SAFETY [PDF]

Annals of Mechnikov's Institute, 2016
Vaccination success depends not only on the timely coverage of threatened contingents, but also on the quality of vaccines. Every day, the requirements for security guarantees vaccines and their use guarantees of security increases.
Isayenko Ye. Yu, Babych Ye. M, Yelyseyeva I. V, Zhdamarova L. A, Belozersky V. I., Kolpak S. A   +5 more
doaj   +1 more source

Diphtheritic myocarditis: A case series and review of literature

Journal of Family Medicine and Primary Care, 2020
Myocarditis in patients with diphtheria is a toxin-mediated complication that sets in after one week of onset of respiratory illness. Early administration of antidiphtheritic serum in patients with clinical diphtheria before the onset of myocarditis is ...
Sonali Singh, Nitin Gupta, Pallavi Saple
doaj   +1 more source

Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia

Iranian Journal of Microbiology, 2022
Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana, Diana Intan Gabriella Lusiana, Andi Yasmon   +2 more
doaj   +1 more source

Diphtheria toxin time-resolved absorption and resonance ft-ir and raman biospectroscopy and density functional theory (dft) investigation of vibronic-mode coupling structure in vibrational spectra analysis: a spectroscopic study on an anti-cancer drug

Clinical Case Studies and Reports, 2019
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source

Corynebacterium diphtheriae: diphtheria toxin, the tox operon and its regulation by Fe2+-activation of apo-DtxR

Microbiology spectrum, 2019
Diphtheria is one of the most well studied of all the bacterial infectious diseases. These milestone studies of toxigenic Corynebacterium diphtheriae along with its primary virulence determinant, diphtheria toxin, have established the paradigm for the ...
S. Parveen, W. Bishai, J. Murphy
semanticscholar   +1 more source

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein that depletes Tregs, was approved
Laurene S. Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, S. Parveen, C. K. Bullen, G. Patrick, R. Harrison, J. Murphy, D. Pardoll, W. Bishai   +12 more
semanticscholar   +1 more source

Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.

JCI Insight, 2016
Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in
J. Gardenier, Geoffrey E. Hespe, Raghu P. Kataru, I. Savetsky, J. Torrisi, G. G. Nores, Joseph Dayan, David W. Chang, Jamie C. Zampell, Ines Martinez-Corral, Sagrario Ortega, B. Mehrara   +11 more
semanticscholar   +1 more source