Results 21 to 30 of about 71,467 (221)

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity [PDF]

, 2005
Langerhans cells (LC) form a unique subset of dendritic cells ( DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC ( dDC).
Clausen, B.E., Inaba, K, Jung, S, Erwin van Rijn, van Rijn, E., Ralph M. Steinman, Clausen, Björn E., Inaba, K., Jung, S., van Rijn, Erwin, Steffen Jung, Clausen, BE, Kapsenberg, Martien L., Kayo Inaba, Inaba, Kayo, van Rijn, E, Bennett, CL, Kapsenberg, ML, Kapsenberg, M.L., Björn E. Clausen, Martien L. Kapsenberg, Jung, Steffen, Steinman, RM, Bennett, C., Steinman, R.M., Bennett, Clare L., Steinman, Ralph M., Clare L. Bennett   +27 more
core   +1 more source

Diphtheritic myocarditis: A case series and review of literature

Journal of Family Medicine and Primary Care, 2020
Myocarditis in patients with diphtheria is a toxin-mediated complication that sets in after one week of onset of respiratory illness. Early administration of antidiphtheritic serum in patients with clinical diphtheria before the onset of myocarditis is ...
Sonali Singh, Nitin Gupta, Pallavi Saple
doaj   +1 more source

Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia

Iranian Journal of Microbiology, 2022
Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana, Diana Intan Gabriella Lusiana, Andi Yasmon   +2 more
doaj   +1 more source

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Nature Communications, 2017
Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos   +10 more
doaj   +1 more source

Novel Corynebacterium diphtheriae in domestic cats [PDF]

, 2010
Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic ...
Hans P. Hinrikson, Whitney, Anne M., Maria L. Tondella, Frances Bolt, Bolt, Frances, Bernard, Kathryn A., Steigerwalt, Arnold G., Masaaki Iwaki, Pamela K. Cassiday, Komiya, Takako, Baldwin, Adam, Kathryn A. Bernard, Pawloski, Lucia C., Lucia C. Pawloski, Motohide Takahashi, Danae Bixler, Cassiday, Pamela K., Takahashi, Motohide, Adam Baldwin, Takako Komiya, Tondella, Maria L., Hinrikson, Hans P., Bixler, Danae, Arnold G. Steigerwalt, Dowson, Christopher G., Aron J. Hall, Christopher G. Dowson, Hall, Aron J., Iwaki, M., Anne M. Whitney   +29 more
core   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
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The INFLUENCE OF PHYSICAL AND PHYSICOCHEMICAL FACTORS ON IMMUNOBIOLOGICAL properties of diphtheria toxin [PDF]

Annals of Mechnikov's Institute, 2011
The influence of physical (ultrasound, temperature) and physicochemical (formalin, temperature, ultrasound) factors on the immunobiological properties of diphtheria toxin and its modifications was studied.
Katrych V.A., Kovalenko O.I., Sklyar N.I., Ryzhkova T.A., Gorbunov L.V., Ryabovol E.V., Kivva F.V., Babych, E.M., Kalinichenko S.V., Zhdamarova L.A., Bobyreva I.V., Kalinichenko E.O.   +11 more
doaj  

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source

Myofibrillar degeneration with diphtheria toxin

, 2020
Objectives: Cardiac damage in patient with diphtheritic myocarditis is reported as the leading cause of mortality. Diphtheria toxin (DTx) is a well-known bacterial toxin inducing various cytotoxic effects.
Nurten, Rustem, Edis, Bilge, Bektas, Muhammet   +2 more
core   +1 more source