Results 41 to 50 of about 215,613 (217)

pH-dependent energy profile of diphtheria toxin (1DDT).

, 2015
pH-dependent energy profile of diphtheria toxin (1DDT).
Prashant Shingate (146643), Ramanathan Sowdhamini (5068), Jim Warwicker (12788)   +2 more
core   +1 more source

Transmission of toxigenic Corynebacterium ulcerans infection with airway obstruction from cats to a human

Acute Medicine & Surgery, 2021
Background Infections caused by Corynebacterium ulcerans, a zoonotic pathogen, have been reported worldwide. This microorganism is known to produce the diphtheria toxin and cause diphtheria‐like illness.
Koji Wake, Jin Kikuchi, Masatoshi Uchida, Masato Nemoto, Yoshiyuki Kaji, Tatsuya Yokoyama, Hiromichi Suzuki, Atsuhito Fukushima, Akihiko Yamamoto, Masaaki Iwaki, Kazuyuki Ono   +10 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

DETERMINATION OF REGIMES FOR DIPHTHERIA EXOTOXIN MODIFICATION BY CHEMICAL AND PHYSICOCHEMICAL METHODS [PDF]

Annals of Mechnikov's Institute, 2011
The possibility of diphtheria toxoid obtaining using chemical (amino sugars, organic acids) and physicochemical (amino sugars, organic acids, ultrasound, temperature) factors was studied.
Antusheva T.I., Pluhator T.M., Ryabovol O.V., Sklyar N.I., Ryzhkova T.A., Kalinichenko S.V., Babych E.M., Panova C.V.   +7 more
doaj  

Determining Induction Conditions for Expression of Truncated Diphtheria Toxin and Pseudomonas Exotoxin A in E. coli BL21

Novelty in Biomedicine, 2018
Background: Targeted cancer therapies have played a great role in the treatment of malignant tumors, in the recent years. Among these therapies, targeted toxin therapies such as immunotoxins, has improved the patient’s survival rate by minimizing the ...
Sahel Amoozadeh, Maryam Hemmati, Mohammad Morad Farajollahi, Neda Akbari, Parastoo Tarighi   +4 more
doaj   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Testicular cell selective ablation using diphtheria toxin receptor transgenic mice

, 2018
Testis development and function is regulated by intricate cell-cell cross talk. Characterization of the mechanisms underpinning this has been derived through a wide variety of approaches including pharmacological manipulation, transgenics, and cell ...
Diane Rebourcet, Peter O’Shaughnessy, Smith, Lee B, Lee B. Smith, Michael Curley, Curley, Michael, O'Shaughnessy, Peter, Rebourcet, Diane, Darbey, Annalucia, Smith, Lee B., Annalucia Darbey   +10 more
core   +1 more source

The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family

Toxins, 2015
The cholix toxin gene (chxA) was first identified in V. cholerae strains in 2007, and the protein was identified by bioinformatics analysis in 2008. It was identified as the third member of the diphtheria toxin group of mono-ADP-ribosyltransferase toxins
Miguel R. Lugo, A. Rod Merrill
doaj   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

DIPHTHERIA AS A SYSTEMIC DISEASE: ANALYSIS OF COMPLICATIONS ASSOCIATED WITH DIPHTHERIA TOXIN [PDF]

Diphtheria is a contagious disease caused by the bacteria Corynebacterium diphtheriae. This disease, although morbidity has significantly decreased in developed nations thanks to immunizations, continues to provide a substantial health risk in areas with
Patrycja Jędrzejewska-Rzezak, Tytus Tyralik, Monika Czekalska, Aleksandra Winsyk, Natalia Kulicka, Maciej Karwat, Kinga Knutelska, Klaudia Bilińska, Joanna Węgrzecka, Paulina Gajniak   +9 more
core   +1 more source