Results 41 to 50 of about 542,716 (249)

Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia

Iranian Journal of Microbiology, 2022
Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana, Diana Intan Gabriella Lusiana, Andi Yasmon   +2 more
doaj   +1 more source

Diphtheria toxin time-resolved absorption and resonance ft-ir and raman biospectroscopy and density functional theory (dft) investigation of vibronic-mode coupling structure in vibrational spectra analysis: a spectroscopic study on an anti-cancer drug

Clinical Case Studies and Reports, 2019
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source

Corynebacterium diphtheriae: diphtheria toxin, the tox operon and its regulation by Fe2+-activation of apo-DtxR

Microbiology spectrum, 2019
Diphtheria is one of the most well studied of all the bacterial infectious diseases. These milestone studies of toxigenic Corynebacterium diphtheriae along with its primary virulence determinant, diphtheria toxin, have established the paradigm for the ...
S. Parveen, W. Bishai, J. Murphy
semanticscholar   +1 more source

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein that depletes Tregs, was approved
Laurene S. Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, S. Parveen, C. K. Bullen, G. Patrick, R. Harrison, John R. Murphy, D. Pardoll, William R. Bishai   +12 more
semanticscholar   +1 more source

Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.

JCI Insight, 2016
Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in
J. Gardenier, Geoffrey E. Hespe, Raghu P. Kataru, I. Savetsky, J. Torrisi, Gabriela D. García Nores, Joseph Dayan, David W. Chang, Jamie C. Zampell, I. Martinez-Corral, Sagrario Ortega, B. Mehrara   +11 more
semanticscholar   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
core   +2 more sources

Protein Translocation by Bacterial Toxin Channels: A Comparison of Diphtheria Toxin and Colicin Ia [PDF]

, 2006
Regions of both colicin Ia and diphtheria toxin N-terminal to the channel-forming domains can be translocated across planar phospholipid bilayer membranes.
Lai, Bing, Wu, Zhengyan, Jakes, Karen S., Samelson-Jones, Ben S., Finkelstein, Alan, Zhao, Gang, London, Erwin   +6 more
core   +1 more source

The INFLUENCE OF PHYSICAL AND PHYSICOCHEMICAL FACTORS ON IMMUNOBIOLOGICAL properties of diphtheria toxin [PDF]

Annals of Mechnikov's Institute, 2011
The influence of physical (ultrasound, temperature) and physicochemical (formalin, temperature, ultrasound) factors on the immunobiological properties of diphtheria toxin and its modifications was studied.
Katrych V.A., Kovalenko O.I., Sklyar N.I., Ryzhkova T.A., Gorbunov L.V., Ryabovol E.V., Kivva F.V., Babych, E.M., Kalinichenko S.V., Zhdamarova L.A., Bobyreva I.V., Kalinichenko E.O.   +11 more
doaj  

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source