Results 61 to 70 of about 542,716 (249)

Determining Induction Conditions for Expression of Truncated Diphtheria Toxin and Pseudomonas Exotoxin A in E. coli BL21

Novelty in Biomedicine, 2018
Background: Targeted cancer therapies have played a great role in the treatment of malignant tumors, in the recent years. Among these therapies, targeted toxin therapies such as immunotoxins, has improved the patient’s survival rate by minimizing the ...
Sahel Amoozadeh, Maryam Hemmati, Mohammad Morad Farajollahi, Neda Akbari, Parastoo Tarighi   +4 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family

Toxins, 2015
The cholix toxin gene (chxA) was first identified in V. cholerae strains in 2007, and the protein was identified by bioinformatics analysis in 2008. It was identified as the third member of the diphtheria toxin group of mono-ADP-ribosyltransferase toxins
Miguel R. Lugo, A. Rod Merrill
doaj   +1 more source

ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXIN

Journal of Experimental Medicine, 1909
The foregoing and earlier data taken together demonstrate that an active immunity lasting several years can be produced in guinea-pigs, by the injection of toxin-antitoxin mixtures which have no recognizable harmful effect either immediate or remote ...
Theobald Smith
semanticscholar   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIC-CO-GLYCOLIC)ACID MICROPARTICLES LOADED BY DIPHTHERIA TOXOID [PDF]

Biotechnologia Acta, 2018
The aim of the study was to synthesize poly(D,L-lactide-co-glycolide) particles — PLGA and obtain their complexes with a non-toxic diphtheria toxin recombinant fragment subunit B fused with enhanced green fluorescent protein EGFP-SubB; to characterize ...
T. O. Chudina, V. A. Skoryk, E. I. Legach   +2 more
doaj   +1 more source

Whole-genome sequencing data of Corynebacterium diphtheriae isolated from diphtheria outbreaks in Indonesia

Data in Brief, 2022
Corynebacterium diphtheriae (C. diphtheriae) is the causative agent of diphtheria. The main virulence factor of C. diphtheriae is diphtheria toxin, which is encoded by the tox gene and regulated by the dtxR gene.
Vivi Setiawaty, Nelly Puspandari, Ratih Dian Saraswati, Dwi Febriyana, Tati Febrianti, Yuni Rukminiati, Fauzul Muna, Fitriana Fitriana, Dodi Safari, Rahadian Pratama, Lisa Andriani Lienggonegoro, Sunarno Sunarno   +11 more
doaj   +1 more source

Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries

Nature Communications, 2021
Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient.
G. Berbers, P. V. van Gageldonk, J. van de Kassteele, U. Wiedermann, I. Desombere, T. Dalby, J. Toubiana, S. Tsiodras, Ildikó Paluska Ferencz, Kathryn Mullan, A. Griškevičius, Tatjana Kolupajeva, D. Vestrheim, P. Palminha, O. Popovici, L. Wehlin, T. Kastrin, L. Maďarová, H. Campbell, C. Ködmön, S. Bacci, A. Barkoff, Qiu-Shui He   +22 more
semanticscholar   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Genome Analysis of Corynebacterium ulcerans Isolates Chronologically Recovered From the Same Cat for Two Years: Circulation in a Cat Shelter

Microbiology and Immunology, EarlyView.
ABSTRACT Toxigenic Corynebacterium ulcerans, a zoonotic pathogen, was isolated repeatedly from a cat in an in‐house group in Japan. Although the cat was cured once by antibiotic treatment, clonal isolates of the original pathogenic strain were recovered repeatedly during a 2‐year course.
Ryoko Jikihara, Miyuki Kimura, Hyun Kim, Tsuyoshi Sekizuka, Masatomo Morita, Makoto Kuroda, Akihiko Yamamoto, Mitsutoshi Senoh, Masaaki Iwaki   +8 more
wiley   +1 more source