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Diphtheria Toxin and the Diphtheria-Toxin Receptor
2000The discovery of diphtheria toxin from culture medium of Corynehacterium diphtheriae was one of the greatest discoveries in medical history. Since this epoch-making change in medicine, diphtheria toxin has been studied, first to prevent disease and later to understand the pathogenic mechanism at the molecular level. A number of important discoveries in
T. Umata, K. D. Sharma, E. Mekada
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The Reaction of the Rat to Diphtheria Toxin
Journal of Immunology, 1921Zingher's method of injecting intracutaneously in guinea-pigs is described. It is shown that constant results can be obtained with the Roemer technic only if the larger guinea-pigs are used (over 400 grams).
A. Coca +2 more
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The Journal of Immunology, 1935
Summary Semi-synthetic medium for toxin production by C. diphtheriae is quite convenient in preparation and also economical. Toxin produced in the medium described above is as potent as that produced in the ordinary-infusion bouillon. Anatoxin prepared from this toxin does not flocculate when mixed with graded amounts of antitoxin and ...
K Ando, T Komiyama
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Summary Semi-synthetic medium for toxin production by C. diphtheriae is quite convenient in preparation and also economical. Toxin produced in the medium described above is as potent as that produced in the ordinary-infusion bouillon. Anatoxin prepared from this toxin does not flocculate when mixed with graded amounts of antitoxin and ...
K Ando, T Komiyama
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On the formation of diphtheria toxin in saliva byC. diphtheriae
Antonie van Leeuwenhoek, 19531. The iron contents of a number of saliva samples were determined. The iron contents found varied from 0.10–0.61 γ per g of saliva, while in some cases the iron quantity present was so small that it could not be determined. 2. These iron contents are of the same quantitative order as the concentrations of this element in the various ...
A, TASMAN, L, SMITH
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Diphtheria toxin (Corynebacterium diphtheriae)
1997Abstract Diphtheria toxin is the primary virulence factor of toxigenic C. diphtheriae the etiologic agent of clinical diphtheria (Pappenheimer 1977). The structural gene for diphtheria toxin, tox, is carried by a closely related family of corynebacteriophages of which the β-phage has been the best studied (Buck et al.
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2000
Abstract Diphtheria toxin (DTX) is a polypeptide of approximately 60 kDa secreted by the bacterium Corynebacterium diphtheriae, a gram-positive nonsporulating rod. Infection with the bacterium in the nasopharynx and subsequent release of toxin into the circulation accounts for the local and systemic manifestations of diphtheria, a ...
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Abstract Diphtheria toxin (DTX) is a polypeptide of approximately 60 kDa secreted by the bacterium Corynebacterium diphtheriae, a gram-positive nonsporulating rod. Infection with the bacterium in the nasopharynx and subsequent release of toxin into the circulation accounts for the local and systemic manifestations of diphtheria, a ...
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Diphtheria Toxin Fusion Proteins
1998Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
F M, Foss +4 more
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Iron and Diphtheria Toxin Production
1975The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture.
S V, Gadre, S S, Rao
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain
Biochemical and Biophysical Research Communications, 1982Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
L, Eidels, L L, Ross, D A, Hart
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Nature, 1968
ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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