Results 171 to 180 of about 87,166 (220)

Crystallization of diphtheria toxin

Journal of Molecular Biology, 1991
Two new crystal forms (forms III and IV) have been grown of diphtheria toxin (DT), which kills susceptible cells by catalyzing the ADP-ribosylation of elongation factor 2, thereby stopping protein synthesis. Forms III and IV diffract to 2.3 A and 2.7 A resolution, respectively.
G, Fujii, S H, Choe, M J, Bennett, D, Eisenberg   +3 more
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Diphtheria Toxin

The Journal of Immunology, 1929
Abstract The preparation of diphtheria toxins from the time of its discovery by Behring has been repeatedly investigated with the development of many changes in its preparation, but it still presents many difficulties. The urgent need of strong potent toxins for the Ramon flocculation tests for titration of diphtheria antitoxins, and ...
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain

Biochemical and Biophysical Research Communications, 1982
Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
L, Eidels, L L, Ross, D A, Hart
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Diphtheria Toxin Fusion Proteins

1998
Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
F M, Foss, M N, Saleh, J G, Krueger, J C, Nichols, J R, Murphy   +4 more
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Diphtheria toxin (Corynebacterium diphtheriae)

1997
Abstract Diphtheria toxin is the primary virulence factor of toxigenic C. diphtheriae the etiologic agent of clinical diphtheria (Pappenheimer 1977). The structural gene for diphtheria toxin, tox, is carried by a closely related family of corynebacteriophages of which the β-phage has been the best studied (Buck et al.
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Iron and Diphtheria Toxin Production

1975
The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture.
S V, Gadre, S S, Rao
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Diphtheria toxin

Cold Spring Harbor Protocols, 2006
Diana Marra Oram, Randall K. Holmes
  +4 more sources

The Diphtheria Toxin Structural Gene

1985
While there was considerable indirect evidence that toxinogenesis in Corynebacterium diphtheria was related to lysogeny (FREEMAN 1951; FREEMAN AND MORSE 1952; GROMAN 1953 a, b, 1955; GROMAN and EATON 1955; HOLMES and BARKSDALE 1969), it was not until the report of UCHIDA et al.
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Potent Diphtheria Toxin within the Cells of C. diphtheriae

Nature, 1954
ALL the exotoxins except diphtheria toxin have been demonstrated within the bacterial cells in a very early stage of culture. So far as diphtheria toxin is concerned, it has been postulated, but never proved, that the exotoxin is formed within the cell.
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Diphtheria Toxin

2008
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