Results 201 to 210 of about 362,065 (266)

The Molecular Pathways of Diphtheria Toxin: Potential Consequences for Drug Design

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Diphtheria toxin; the iron enzymes of Corynebacterium diphtheriae and their possible relation to diphtheria toxin.

The Journal of biological chemistry, 2010
A M, PAPPENHEIMER, E D, HENDEE
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Diphtheria Toxin

Definitions, 2020
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Hydrogen-Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin.

Biochemistry, 2019
The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination.
Shaolong Zhu, Peter Liuni, Luciano Ettorre, Tricia Chen, J. Szeto, B. Carpick, D. A. James, Derek J. Wilson   +7 more
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Diphtheria Toxin and the Diphtheria-Toxin Receptor

2000
The discovery of diphtheria toxin from culture medium of Corynehacterium diphtheriae was one of the greatest discoveries in medical history. Since this epoch-making change in medicine, diphtheria toxin has been studied, first to prevent disease and later to understand the pathogenic mechanism at the molecular level. A number of important discoveries in
T. Umata, K. D. Sharma, E. Mekada
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Diphtheria Toxin

The Journal of Immunology, 1935
Summary Semi-synthetic medium for toxin production by C. diphtheriae is quite convenient in preparation and also economical. Toxin produced in the medium described above is as potent as that produced in the ordinary-infusion bouillon. Anatoxin prepared from this toxin does not flocculate when mixed with graded amounts of antitoxin and ...
K Ando, T Komiyama
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Crystallization of diphtheria toxin

Journal of Molecular Biology, 1991
Two new crystal forms (forms III and IV) have been grown of diphtheria toxin (DT), which kills susceptible cells by catalyzing the ADP-ribosylation of elongation factor 2, thereby stopping protein synthesis. Forms III and IV diffract to 2.3 A and 2.7 A resolution, respectively.
G, Fujii, S H, Choe, M J, Bennett, D, Eisenberg   +3 more
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain

Biochemical and Biophysical Research Communications, 1982
Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
L, Eidels, L L, Ross, D A, Hart
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The Reaction of the Rat to Diphtheria Toxin

Journal of Immunology, 1921
Zingher's method of injecting intracutaneously in guinea-pigs is described. It is shown that constant results can be obtained with the Roemer technic only if the larger guinea-pigs are used (over 400 grams).
A. Coca, Ernest F. Russell, William H. Baughman   +2 more
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Diphtheria Toxin Fusion Proteins

1998
Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
F M, Foss, M N, Saleh, J G, Krueger, J C, Nichols, J R, Murphy   +4 more
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