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The crystal structure of diphtheria toxin
Nature, 1992The crystal structure of the diphtheria toxin dimer at 2.5 A resolution reveals a Y-shaped molecule of three domains. The catalytic domain, called fragment A, is of the alpha + beta type. Fragment B actually consists of two domains. The transmembrane domain consists of nine alpha-helices, two pairs of which are unusually apolar and may participate in ...
Gary Fujii +6 more
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Diphtheria Toxin Fusion Proteins
1998Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
James G. Krueger +4 more
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The Reaction of the Rat to Diphtheria Toxin
Journal of Immunology, 1921Zingher's method of injecting intracutaneously in guinea-pigs is described. It is shown that constant results can be obtained with the Roemer technic only if the larger guinea-pigs are used (over 400 grams).
A. Coca +2 more
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain
Biochemical and Biophysical Research Communications, 1982Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
Lisa L. Ross, Leon Eidels, David A. Hart
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The Effects of Inhibitors Upon Pore Formation by Diphtheria Toxin and Diphtheria Toxin T Domain
Journal of Membrane Biology, 1999The formation of pores by membrane-inserted diphtheria toxin is closely linked to the translocation of its catalytic chain across membranes. In this report a number of aromatic polyanionic molecules were identified that inhibit toxin-induced leakage of molecules from model membrane vesicles. One inhibitor, Cibacron blue, totally blocked pore formation.
Kelli Kachel, J.C. Sharpe, Erwin London
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Iron and Diphtheria Toxin Production
1975The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture.
S. S. Rao, S. V. Gadre
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Nature, 1968
ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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The Diphtheria Toxin Structural Gene
1985While there was considerable indirect evidence that toxinogenesis in Corynebacterium diphtheria was related to lysogeny (FREEMAN 1951; FREEMAN AND MORSE 1952; GROMAN 1953 a, b, 1955; GROMAN and EATON 1955; HOLMES and BARKSDALE 1969), it was not until the report of UCHIDA et al.
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[11] Diphtheria toxin: Purification and properties
1988Publisher Summary This chapter describes the purification and properties of diphtheria toxin (DT). The chapter also discusses the purification of DT from toxin preparations obtained from commercial sources, and its subsequent fractionation into the various forms.
Joseph T. Barbieri +2 more
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