Results 11 to 20 of about 11,571 (204)
Diploidy confers genomic instability in Schizosaccharomyces pombe [PDF]
GENETICSAbstractWhole genome duplication, or polyploidy, has been implicated in driving genome instability and tumorigenesis. Recent studies suggest that polyploidy in tumors promotes cancer genome evolution, progression, and chemoresistance resulting in worse prognosis of survival.
Joshua M Park +2 more
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Calcium Homeostasis Is Involved in the Modulation of Gene Expression by MSL2 in Imbalanced Genomes [PDF]
CellsAneuploidy is highly detrimental to organisms due to genomic imbalance. However, the influence of parental unbalanced genome conditions on gene expression of their offspring remains unclear, particularly in animals.
Ruixue Wang +5 more
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Mutation accumulation may only be a minor force in shaping life-history traits, even when reproduction is sexual. [PDF]
PLoS ONE, 2012 In a previous theoretical study we investigated whether adaptive or non-adaptive processes are more important in the evolution of senescence. We built a model that combined both processes and found that mutation accumulation is important only at those ...
Maciej Jan Dańko, Jan Kozłowski
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Evolutionary route to diploidy and sex [PDF]
Proceedings of the National Academy of Sciences, 2001 By using a bit-string model of evolution, we find a successful route to diploidy and sex in simple organisms. Allowing the sexually reproducing diploid individuals to also perform mitosis, as they do in a haploid-diploid cycle, leads to the complete takeover of the population by sexual diploids.
Tuzel, E, Sevim, V, Erzan, A
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Journal of Pharmacy and Bioallied Sciences, 2020 Background: Methods to analyze progression of carcinogenesis and stage of cancer are vital nowadays due to the high prevalence of these lesions. DNA ploidy analysis is one such important method in early diagnosis and improving prognosis.
Surekha Velidandla +5 more
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The evolution of haploidy and diploidy [PDF]
Current Biology, 2008 It is remarkable that one of the most fundamental features of an organism — its ploidy level — is so variable among taxa, with life cycles running the entire gamut from complete haploid dominance to complete diploid dominance. Theoretical studies have clarified many important genetic advantages to haploidy (for example, lower mutation load, more rapid ...
Otto, Sarah P., Gerstein, Aleeza C.
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Effects of ploidy and recombination on evolution of robustness in a model of the segment polarity network. [PDF]
PLoS Computational Biology, 2009 Many genetic networks are astonishingly robust to quantitative variation, allowing these networks to continue functioning in the face of mutation and environmental perturbation. However, the evolution of such robustness remains poorly understood for real
Kerry J Kim, Vilaiwan M Fernandes
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Ancient evolutionary trade-offs between yeast ploidy states. [PDF]
PLoS Genetics, 2013 The number of chromosome sets contained within the nucleus of eukaryotic organisms is a fundamental yet evolutionarily poorly characterized genetic variable of life.
Enikö Zörgö +8 more
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Critical mutation rate has an exponential dependence on population size in haploid and diploid populations [PDF]
, 2013 Understanding the effect of population size on the key parameters of evolution is particularly important for populations nearing extinction. There are evolutionary pressures to evolve sequences that are both fit and robust.
Aston, E, Channon, A, Day, C, Knight, CG
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The mutational meltdown in asexual populations [PDF]
, 1993 Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of
Butcher, D. +3 more
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