Results 171 to 180 of about 48,247 (244)

Editorial on "Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: A nationwide cohort study". [PDF]

Clin Mol Hepatol
Ong YL, Kaewdech A, Huang DQ, Wong YJ.
europepmc   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Sicca manifestations and lymphoproliferation in hepatitis C virus: effects of direct acting antiviral therapy on dryness and B-cell activity compared to Sjögren's disease. [PDF]

Arthritis Res Ther
Maher A, Hegazy MT, Algarf TM, Abdul-Aziz MA, Quartuccio L, Zoheir N, De Vita S, Ragab G.   +7 more
europepmc   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

Intermediate-term risk of cardiac allograft vasculopathy following heart transplantation from hepatitis C viremic donors in the era of direct-acting antiviral therapy. [PDF]

JHLT Open
Paternostro K, Birs A, Aslam S, Adler E, Hong K, Wettersten N.   +5 more
europepmc   +1 more source

Superior Intracellular Detection of Cytokines, Transcription Factors, and Phosphoproteins by CyTOF Compared With Fluorescent Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Unraveling biological complexity, such as immune subset distribution in infectious disease(s), autoimmunity, or tumor heterogeneity, requires technologies capable of single‐cell proteomic analysis such as flow cytometry. Surface phenotyping alone is often insufficient, as interrogating functional capacity is required to determine cellular ...
Michael J. Cohen, Erika L. Smith‐Mahoney, Madison Bailey, Ling Wang, Lauren J. Tracey, Laura Polanco, David King, Christina Loh, Amedeo J. Cappione III, Anna C. Belkina, Jennifer E. Snyder‐Cappione   +10 more
wiley   +1 more source

Deep Sequencing Analysis of Hepatitis C Virus Subtypes and Resistance-Associated Substitutions in Genotype 4 Patients Resistant to Direct-Acting Antiviral (DAA) Treatment in Egypt. [PDF]

Int J Mol Sci
Garcia-Cehic D, Mosbeh A, A Gad H, Gomaa AI, Ibañez Lligoña M, Gregori J, Colomer-Castell S, Campos C, Rodriguez-Frias F, Esteban JI, Kohla MS, Abdel-Rahman MH, Quer J.   +12 more
europepmc   +1 more source

Synthesis of Sulfur Heterocycles by Palladium‐Catalyzed Cyclization

European Journal of Organic Chemistry, EarlyView.
In spite of the well‐known palladium thiophilicity, sulfur‐containing acyclic substrates may efficiently undergo several different kinds of palladium‐catalyzed cyclization processes leading to highly important sulfur heterocycles in one synthetic step. Advances in this challenging and stimulating field of research are presented in this review.
Bartolo Gabriele
wiley   +1 more source

Clearance of Hepatitis C Viremia During Direct-Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism. [PDF]

Aliment Pharmacol Ther
Sarrafan-Chaharsoughi Z, Takyar V, Auh S, Nee G, Alawad A, Abel BS, Kapuria D, Byrnes C, Wolska A, Kleiner DE, Shamburek R, Remaley AT, Ghany MG.   +12 more
europepmc   +1 more source

Synthesis of Heterocyclic Scaffolds from Nitrobenzyl Alcohols Using Reduction‐Generated Azaquinone Methides and Cyclization

European Journal of Organic Chemistry, EarlyView.
Intramolecular cyclization to quench an in situ reduction‐generated azaquinone methide is a strategy that could be used for late‐stage heterocycle synthesis. Herein, synthetically accessible 4‐nitrobenzyl alcohols with a nucleophilic handle adjacent to the benzyl alcohol group are reduced under mild conditions to afford six‐ and seven‐membered ...
Harrison M. Lewin, Lavleen K. Mader, Veera V. Shivaji R. Edupuganti, Bill C. Hawkins, Allan B. Gamble   +4 more
wiley   +1 more source