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Direct acting antiviral therapy after liver transplantation
Current Opinion in Gastroenterology, 2016Historically, postliver transplant patients with chronic hepatitis C have had worse outcomes than nonhepatitis C-related causes because of accelerated fibrosis posttransplantation and the lack of effective well tolerated therapies for hepatitis C, and posttransplant hepatitis C patients have been considered a special population.
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Direct acting antivirals failure: cause and retreatment options
Expert Review of Gastroenterology & Hepatology, 2018Chronic hepatitis C (HCV) infection is a systemic life-threatening condition that can lead to hepatic and extra-hepatic complications. Sustained virological response (SVR) is associated with a regression of most liver and non-liver manifestations, which reduce mortality.
Lucia, Parlati, Stanislas, Pol
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[Direct-acting antiviral-resistant variant].
Nihon rinsho. Japanese journal of clinical medicine, 2015Recently, IFN-free NS5A inhibitor daclatasvir and protease inhibitor asunaprevir combination treatment was approved for genotype 1b HCV-infected patients who were ineligible or who failed to respond to previous therapies. NS5A inhibitor-resistant variants occasionally exist in HCV-infected patients who have never been exposed to direct-acting ...
Michio, Imamura, Kazuaki, Chayama
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Controversies of Direct-Acting Antivirals in Hepatocellular Carcinoma
Surgical Oncology Clinics of North AmericaTherapy for chronic hepatitis C virus infection with direct-acting antiviral agents (DAAs) has been highly successful in achieving sustained virological response (SVR) with associated improvements in liver dysfunction, liver-related mortality, and transplant-free survival.
Ifrah, Fatima +2 more
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Interferon free therapy with direct acting antivirals for HCV
Liver International, 2013AbstractThe current treatment for hepatitis C virus (HCV) genotype 1 chronic infection is the addition of direct‐acting antivirals (DAA) with a protease inhibitor (telaprevir or boceprevir) to the pegylated interferon (PEG‐IFN) plus ribavirin (RBV) regimen.
Tarik, Asselah, Patrick, Marcellin
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Direct-acting antiviral treatment for patients with hepatocellular carcinoma
Current Opinion in Gastroenterology, 2018Hepatocellular carcinoma (HCC) affects a significant portion of patients with hepatitis C. The use of direct-acting antiviral (DAA) agents has transformed the disease outcomes in this patient group.Hepatitis C virus (HCV) response to DAAs can be affected by the presence of HCC, whereas DAA therapy may affect the risk of HCC recurrence in patients with ...
Tatyana, Kushner +2 more
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Direct-Acting Antiviral Agents
Clinics in Liver Disease, 2015Tatyana Kushner, Vandana Khungar
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Direct-acting antiviral treatment for HCV
The Lancet Infectious Diseases, 2016Stelliana, Goutzamanis +4 more
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Direct-acting antiviral (DAA) actions in treatment-naïve patients
Clinics and Research in Hepatology and Gastroenterology, 2011The introduction of telaprevir (TVR) and boceprevir (BOC), the first approved protease inhibitors against hepatitis C virus (HCV), into clinical practice represented the start of an exciting new era of HCV treatment. In addition to improving sustained virological response (SVR) rates in HCV genotype-1 treatment-naïve patients, these drugs administered ...
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Revolutionizing hepatitis C treatment: next-gen direct-acting antivirals
Expert Opinion on PharmacotherapyWith the introduction of highly effective and safe therapies with next-generation direct-acting antivirals (DAAs), that act without interferon, hepatitis C virus (HCV) infection remains the only treatable chronic infectious disease.The review aims to provide an overview of the therapy revolution with a description of specific DAAs, their mechanisms of ...
Krystyna, Dobrowolska +7 more
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