Results 121 to 130 of about 1,348,172 (305)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Best hypotheses search on iso-energy-grid for initial orbit determination and track association

, 2013
Debris populating the geostationary orbit is mainly observed by ground-based optical telescopes. Short measurement arcs, known as tracklets, provide line-of-sight information along with the associated rates of change.
Weigel, Martin, Siminski, Jan, Fiedler, Hauke, Montenbruck, Oliver   +3 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Comparative Evaluation of Machine Learning and Hyperparameter Optimization Methods for Low-Cost CO₂ Sensor Calibration in Terms of Performance and Computational Cost

Sensors
Low-cost sensors (LCSs) are increasingly used in air quality monitoring because of their affordability and scalability; however, their limited accuracy necessitates reliable calibration approaches. Although machine learning (ML)-based calibration methods
Eren Cihan Karsu Asal, Mehmet Taştan, Hayrettin Gökozan, Müge Erel-Özçevik, Yusuf Özçevik   +4 more
doaj   +1 more source

Job Search Assistance Programs in Europe: Evaluation Methods and Recent Empirical Findings [PDF]

Job search assistance programs are part of active labor market policy in many countries. The main characteristics of these activities are an intensi ed counseling and a job search monitoring; in addition, several countries integrate courses teaching ...
Stephan Thomsen
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Improved New Two-Spectral Conjugate Gradient Iterative Technique for Large Scale Optimization

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Numerous strategies have been proposed in the field of unconstrained optimization to address various optimization challenges, particularly those associated with large-scale systems. Among the classical methods, Newton and Quasi-Newton approaches are well-
Radhwan Basem Thanoon, Ghada Moayid Al-Naemi   +1 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Quantum Enhancements for Direct Search Methods

This dissertation explores the use of quantum search algorithms to im- prove direct search methods for single and multiobjective optimization. Quantum search algorithms are known to reduce the expected number of oracle calls needed to find the solution ...
Mikes, Colton
core