Results 41 to 50 of about 1,348,172 (305)

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters   +17 more
wiley   +1 more source

ethods in higher education in Latin American. Period 2010-2020

open access: yesPoblación y Desarrollo, 2022
In this work, the teaching methods used in Latin American transcendental literature were analyzed. They were selected by keywords: "teaching methods", "teaching techniques", "teaching", "teaching-learning process", "educational research" and "learning ...
Derlis Daniel Lugo
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho   +7 more
wiley   +1 more source

An Approximation of Minimum Initial Capital of Investment Discrete Time Surplus Process with Weibull Distribution in a Reinsurance Company

open access: yesJournal of Applied Mathematics, 2019
Catastrophe is a loss that has a low probability of occurring but can lead to high-cost claims. This paper uses the data of fire accidents from a reinsurance company in Thailand for an experiment. Our study is in two parts.
Soontorn Boonta, Somchit Boonthiem
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

New perspectives on Web search engine research [PDF]

open access: yes, 2012
Purpose–The purpose of this chapter is to give an overview of the context of Web search and search engine-related research, as well as to introduce the reader to the sections and chapters of the book.
Lewandowski, Dirk
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Using Simplex Gradients of Nonsmooth Functions in Direct Search Methods [PDF]

open access: yes, 2006
It has been shown recently that the efficiency of direct search methods that use opportunistic polling in positive spanning directions can be improved significantly by reordering the poll directions according to descent indicators built from simplex ...
Custodio, A.L.   +2 more
core   +1 more source

Evolutionary Policy Transfer and Search Methods for Boosting Behavior Quality: RoboCup Keep-Away Case Study

open access: yesFrontiers in Robotics and AI, 2017
This study evaluates various evolutionary search methods to direct neural controller evolution in company with policy (behavior) transfer across increasingly complex collective robotic (RoboCup keep-away) tasks.
Geoff Nitschke, Sabre Didi
doaj   +1 more source

Direct search methods in the optimisation of cancer chemotherapy regimens [PDF]

open access: yesBritish Journal of Cancer, 1990
Current cancer chemotherapy regimens may involve 20-30 or more independent variables, each affecting therapeutic response and toxicity. With standard response surface modelling methods, finding the optimum combination with as few as 10 variables entails testing over 1,000 combinations, so these methods do not provide a feasible approach to such ...
openaire   +2 more sources

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